osteoclasts — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T1973	PFI-4	PFI4	Epigenetic Reader Domain
	PFI-4 is a potent and selective and cell-permeable BRPF1 bromodomain inhibitor.		Epigenetic Reader Domain
T9824	WAY-325371		Others
	WAY-325371 can inhibit the formation of osteoclasts.		Others
T2789	Scutellarin	Breviscapin,Breviscapinun,Breviscapine,Scutellarein-7-glucuronide	Akt , HIV Protease , STAT
	Scutellarin (Scutellarein-7-glucuronide), an active flavone isolated from Scutellaria baicalensis, can inhibit RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts, and down-regulate the STAT3/Girdin/Akt signal...		Akt , HIV Protease , STAT
T3808	Icariside I	Lcariside I,Icariin I,Icarisid I	Others
	Icariside I (Lcariside I) is isolated from Epimedium herb. It can stimulate osteogenic differentiation of BMSCs and inhibit bone resorption activity of osteoclasts.		Others
T5770	Alisol B		RANKL/RANK
	Alisol B may be a potential novel therapeutic molecule for bone disorders through targeting the differentiation of osteoclasts as well as their functions. Alisol B also inhibited RANKL-induced expression of NFATc1 and c-...		RANKL/RANK
TN5888	Toddaculin		Others
	Toddaculine may be beneficial for the prevention and treatment of osteoporosis, it can not only inhibit the differentiation of osteoclasts via activation of the NF-κB, ERK 1/2, and p38 MAPK signaling pathways, but can in...		Others
T21460	Teriparatide acetate	hPTH 1-34 (acetate salt),Parathar acetate,Forteo	Others
	Teriparatide acetate (Forteo) is a PHT agonist, with an IC50 of 2 nM in HEK293 cells.Teriparatide acetate is a recombinant form of parathyroid hormone. It is an effective anabolic (i.e., bone growing) agent used to treat...		Others
T1210	Sodium etidronate	Didronel	Phosphatase
	Sodium etidronate (Didronel) is a synthetic therapeutic diphosphonate analog of endogenous pyrophosphate. As a member of the family of drugs known as bisphosphonates, Sodium etidronate differs from endogenous pyrophospha...		Phosphatase
T1641	Strontium ranelate	Distrontium renelate,S12911	Calcium Channel , CaSR
	Strontium ranelate (S12911), a strontium (II) salt of the ranelic acid, is a medication for osteoporosis. Studies indicate it can also slow the course of osteoarthritis of the knee. The drug is unusual in that it both in...		Calcium Channel , CaSR
TN1711	Gossypetin		Antioxidant , p38 MAPK , MAPK , Antibacterial
	Gossypetin, a hexahydroxylated flavonoid extractable from Rhodiola rosea Linn. is a potent MKK3 and MKK6 inhibitor that strongly attenuates the MKK3/6-p38 signaling pathway.Gossypetin exhibits antimutagenic, antiatherosc...		Antioxidant , p38 MAPK , MAPK , Antibacterial
T20338	Methopterin	NSC 107144,alpha-Methopterin,NSC-107144,10-Methylfolic acid,NSC107144
	Methopterin shows the activation and bone resorption function of murine osteoclasts.
T21330	JNJ-28312141	JNJ 28312141,JNJ28312141
	JNJ-28312141 is an orally active CSF1R inhibitor and a FLT3 inhibitor. JNJ-28312141 is a new agent with potential therapeutic activity in acute myeloid leukemia and in settings where CSF-1-dependent macrophages and osteo...
T22559	Alendronate sodium		Others
	The compound binds and blocks farnesyl diphosphate synthase in the HMG-CoA pathway (IC50 = 460 nM for recombinant human FPPS). It causes macrophage apoptosis and inhibits prenylation and sterol biosynthesis in purified o...		Others
TP2098	Echistatin	Echistatin, α1 isoform
	Potent irreversible αVβ3 integrin antagonist (Ki = 0.27 nM). Disrupts attachment of osteoclasts to bone and inhibits bone reabsorption (IC50 = 0.1 nM). Prevents ADP-induced platelet aggregation via inhibition of glycopro...
TN1484	Cheilanthifoline		NF-κB , Antifection
	Cheilanthifoline has anti-osteoclastogenic property, it gives significant inhibitions on receptor activator of nuclear factor-κB ligand-induced differentiation of mouse bone marrow-derived macrophages into multinucleated...		NF-κB , Antifection
T68721	Cantharidin imide
	Cantharidin imide is a PP1/2A inhibitor found in Canarthis vesicatoria. It inhibits proliferation of colorectal cancer cells, increases MCP-1, IL-6, and IL-β levels, and inhibits differentiation and resorptive activity o...
T40463	Relacatib	SB-462795
	Relacatib (SB-462795) is a novel, potent, and orally active inhibitor of human cathepsins K, L, and V. It exhibits high affinity for these enzymes, with Ki values of 41 pM, 68 pM, and 53 pM, respectively. Moreover, Relac...
T36065	N-Oleoyl-L-Serine
	Bone mass and shape is continuously remodeled by the concerted and balanced action of osteoblasts (bone forming cells) and osteoclasts (bone-resorbing cells). The endocannabinoid system plays an essential role in the mai...
T19848	Cyclosporin B	7-L-Alanine-cyclosporin A,Antibiotic S 7481F2
	Cyclosporin B is an immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. Cyclosporin B displays antiviral properties, inhibiting the entry of hepatitis B i...
T78816	Anti-osteoporosis agent-4		NF-κB
	Anti-osteoporosis agent-4 (Compound 11h) suppresses the differentiation of primary osteoclasts and attenuates RANKL-induced osteoclastogenesis. It effectively inhibits osteoclast formation, demonstrating an IC50 value of...		NF-κB