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Scutellarin

Catalog No. T2789   CAS 27740-01-8
Synonyms: Breviscapin, Breviscapinun, Breviscapine, Scutellarein-7-glucuronide

Scutellarin (Scutellarein-7-glucuronide), an active flavone isolated from Scutellaria baicalensis, can inhibit RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts, and down-regulate the STAT3/Girdin/Akt signaling in HCC cells.

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Scutellarin Chemical Structure
Scutellarin, CAS 27740-01-8
Pack Size Availability Price/USD Quantity
10 mg In stock $ 45.00
25 mg In stock $ 77.00
50 mg In stock $ 134.00
100 mg In stock $ 173.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 99.32%
Purity: 98.64%
Purity: 98.28%
Purity: 96.85%
Purity: 95.86%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Scutellarin (Scutellarein-7-glucuronide), an active flavone isolated from Scutellaria baicalensis, can inhibit RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts, and down-regulate the STAT3/Girdin/Akt signaling in HCC cells.
In vitro Scutellarin treatment significantly reduces HepG2 cell viability in a dose-dependent manner. It also inhibits migration and invasion of HCC cells in vitro. Scutellarin treatment significantly reduces STAT3 and Girders of actin filaments (Girdin) expression, STAT3 and Akt phosphorylation in HCC cells. The introduction of STAT3 overexpression restores the scutellarin-downregulated Girdin expression, Akt activation, migration and invasion of HCC cells. Moreover, induction of Girdin overexpression completely abrogates the inhibition of scutellarin on the Akt phosphorylation, migration and invasion of HCC cells. Scutellarin can inhibit HCC cell metastasis in vivo, and migration and invasion in vitro by down-regulating the STAT3/Girdin/Akt signaling[1]. Scutellarin selectively enhances Akt phosphorylation[2]. Scutellarin is a putative therapeutic agent as it has been found to not only suppress microglial activation thus ameliorating neuroinflammation, but also enhance astrocytic reaction. Acutellarin amplifies the astrocytic reaction by upregulating the expression of neurotrophic factors among others thus indicating its neuroprotective role. Remarkably, the effects of scutellarin on reactive astrocytes are mediated by activated microglia supporting a functional 'cross-talk' between the two glial types[3]. Scutellarin can suppress RANKL-mediated osteoclastogenesis, the function of osteoclast bone resorption, and the expression levels of osteoclast-specific genes (tartrate-resistant acid phosphatase (TRAP), cathepsin K, c-Fos, NFATc1). Further investigation indicates that Scutellarin can inhibit RANKL-mediated MAPK and NF-κB signaling pathway, including JNK1/2, p38, ERK1/2, and IκBα phosphorylation[5].
In vivo Scutellarin (50 mg/kg/day) significantly mitigates the lung and intrahepatic metastasis of HCC tumors in vivo. The numbers of lung and intrahepatic metastatic tumors in the scutellarin-treated group are significantly less compared to the controls[1]. The rats treated with Scutellarin display a significant alleviation in neurobehavioral deficits compared to the SAH group. Scutellarin enhanced eNOS expression compared with SAH rats[4].
Cell Research HepG2 cells (1×105/well) are cultured in 96-well plates and treated in triplicate with scutellarin at concentrations of 5, 10, 20, 30, and 100 μM or vehicle alone for 24 h. The cellular viability is tested by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and is expressed as a percentage of proliferation versus controls.
Source
Synonyms Breviscapin, Breviscapinun, Breviscapine, Scutellarein-7-glucuronide
Molecular Weight 462.36
Formula C21H18O12
CAS No. 27740-01-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50mg/mL(108.14 mM)

TargetMolReferences and Literature

1. Ke Y, et al. Scutellarin suppresses migration and invasion of human hepatocellular carcinoma by inhibiting the STAT3/Girdin/Akt activity. Biochem Biophys Res Commun. 2016 Dec 18. pii: S0006-291X(16)32174-X. 2. Yang LL, et al. Differential regulation of baicalin and scutellarin on AMPK and Akt in promoting adipose cell glucose disposal. Biochim Biophys Acta. 2016 Nov 27;1863(2):598-606. 3. Wu CY, et al. Scutellarin attenuates microglia-mediated neuroinflammation and promotes astrogliosis in cerebral ischemia - a therapeutic consideration. Curr Med Chem. 2016 Nov 18. [Epub ahead of print] 4. Li Q, et al. Scutellarin attenuates vasospasm through the Erk5-KLF2-eNOS pathway after subarachnoid hemorrhage in rats. J Clin Neurosci. 2016 Dec;34:264-270. 5. Zhao, S., Sun, Y., Li, X., Wang, J., Yan, L., & Zhang, Z. et al. (2016). Scutellarin inhibits RANKL-mediated osteoclastogenesis and titanium particle-induced osteolysis via suppression of NF-κB and MAPK signaling pathway. International Immunopharmacology, 40, 458-465. doi: 10.1016/j.intimp.2016.09.031 6. Chinnasamy S, Selvaraj G, Selvaraj C, et al. Combining in silico and in vitro approaches to identification of potent inhibitor against phospholipase A2 (PLA2)[J]. International Journal of Biological Macromolecules. 2020, 144: 53-66

TargetMolCitations

1. Chinnasamy S, Selvaraj G, Selvaraj C, et al. Combining in silico and in vitro approaches to identification of potent inhibitor against phospholipase A2 (PLA2). International Journal of Biological Macromolecules. 2020, 144: 53-66 2. Yang X, Liu L, Hao Y, et al. A Bioluminescent Biosensor for Quantifying the Interaction of SARS-CoV-2 and Its Receptor ACE2 in Cells and In Vitro. Viruses. 2021, 13(6): 1055.

Related compound libraries

This product is contained In the following compound libraries:
Glycolysis Compound Library Polyphenolic Natural Product Library Anti-Cancer Metabolism Compound Library Anti-COVID-19 Traditional Chinese Medicine Compound Library Metabolism Compound Library Antioxidant Compound Library Reprogramming Compound Library Anti-Metabolism Disease Compound Library Selected Plant-Sourced Compound Library Inhibitor Library

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Keywords

Scutellarin 27740-01-8 Cytoskeletal Signaling JAK/STAT signaling Microbiology/Virology PI3K/Akt/mTOR signaling Proteases/Proteasome Stem Cells Akt HIV Protease STAT PKB Inhibitor inhibit HIV Protein kinase B Human immunodeficiency virus Breviscapin Breviscapinun Breviscapine Scutellarein-7-glucuronide inhibitor

 

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