modulators — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T39607	NLRP3 modulators 1	NLRP3 modulators 1
	NLRP3 modulators 1 (WO2017184746A1, compound 107) is a potent modulator of NLRP3, capable of agonizing or partially agonizing the activity of NLRP3. This compound proves valuable in investigating conditions, diseases, or...
T11362	Gamma-Secretase Modulators	γ-Secretase Modulators,Amyloid-β production inhibitor	Others
	gamma-Secretase Modulators serves as a useful treatment for Alzheimer's disease by inhibiting the production of Amyloid-β. Specifically, it acts as a gamma-Secretase Modulators with an IC50 value.		Others
T38423	CL097	CL097	Reactive Oxygen Species , TLR
	CL097 is an effective agonist of TLR7 and TLR8. CL097 induces pro-inflammatory cytokines in macrophages and NADPH oxidase priming, thereby increasing the fMLF-stimulated ROS production.		Reactive Oxygen Species , TLR
T7839	Lasofoxifene Tartrate	CP-336156	Estrogen Receptor/ERR
	Lasofoxifene Tartrate (CP-336156) is a third-generation, non-steroidal selective estrogen receptor modulator.		Estrogen Receptor/ERR
T27854	LSN2463359	LSN-2463359,LSN 2463359	GluR
	LSN2463359 is a positive allosteric modulators of the mGlu5 receptor.		GluR
T67734	MCUF-651		Guanylate cyclase
	MCUF-651 is a guanylyl cyclase A receptor positive allosteric modulators, EC50=0.45 μM.		Guanylate cyclase
T8991	BMS986187		Opioid Receptor
	BMS986187 is a novel Potent and Selective Positive Allosteric Modulators of the delta-Opioid Receptor.		Opioid Receptor
T7136	AZD-6280		GABA Receptor
	AZD6280 is a novel, subtype-selective GABAAα2/3 receptor positive modulators, used for treatment of generalized anxiety disorder.		GABA Receptor
T4S1616	Sanggenon D	Sanggenone D	NOS , COX , GABA Receptor
	Sanggenone D represents a new scaffold of positive GABAA receptor modulators, it also inhibits COX-2 activity (IC 50 = 73-100 μM). Sanggenone D has anti-inflammatory activity, it can inhibit NO production from lipopolysa...		NOS , COX , GABA Receptor
T3406	Kuromanin chloride	Glucocyanidin chloride,Chrysontemin,Chrysontemin chloride,Cyanidin 3-O-glucoside chloride	NF-κB
	Kuromanin chloride (Chrysontemin chloride) is potent antioxidants and free radical scavengers, may act as modulators of gene regulation and signal transduction pathways.		NF-κB
TP1330	Cyclo(RADfK)		Integrin
	Cyclo(RADfK) is a selective α(v)β(3) integrin ligand that has been extensively used for research, therapy, and diagnosis of neoangiogenesis.Cyclo(RADfK) is a negative control for the cyclo (-RGDfK-), the RGD peptide. RGD...		Integrin
T3295	1-Methyl-1H-pyrazol-3-amine		Others
	1-Methyl-1H-pyrazol-3-amine is a pyrazole compound. It has been used in the synthesis of various compounds such as drugs, dyes and polymers. It is also an important intermediate in the synthesis of certain drugs. It has ...		Others
T5S2343	Acetylshikonin	Acetyl shikonin	Others , P450 , AChE
	1. Acetylshikonin exhibits weak cytotoxicity against human umbilical vein endothelial cells (HUVECs) with IC5 of over 2 microM, exhibits the antiangiogenic and antitumorigenic effects by suppressing proliferation and ang...		Others , P450 , AChE
T37734	AMPA receptor modulator-2		GluR
	AMPA receptor modulator-2 (Example 134) is a AMPA receptor modulator, with a pIC50 of 10.1 for TARPγ2 dependent AMPA receptor[1]. pIC50 = -lgIC50. [1]. BERRY CYNTHIA G B (US), et al. AZABENZIMIDAZOLES AND THEIR USE AS AM...		GluR
T11409	GLP-26		HBV
	GLP-26 disrupts the encapsidation of pre-genomic RNA, causes nucleocapsid disassembly and reduces cccDNA pools. GLP-26 is a HBV capsid assembly modulators (CAM), inhibits HBV DNA replication in Hep AD38 system (IC50=3 nM...		HBV
T29125	VU0359516	VU 0359516,VU-0359516
	VU0359516 is a mGluR4 positive allosteric modulators.
T26706	AZ4800	AZ-4800,AZ 4800
	AZD4800 is a gamma secretase modulators.
T27449	GSK1331268	GSK 1331268,GSK-1331268
	GSK1331268 is a selective, orally bioavailable positive modulators of mGluR2.
T27448	GSK1331258	GSK 1331258,GSK-1331258
	GSK1331258 is a selective, orally bioavailable positive modulators of mGluR2.
T27496	GSK9772	GSK-9772,GSK 9772
	GSK9772 is a transrepression-selective liver X receptor modulators with anti-inflammatory activity.