mirna — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T10831L	Cl-amidine hydrochloride		Apoptosis , PAD
	Cl-amidine hydrochloride is an orally active peptidylarginine deminase (PAD) inhibitor (IC50: 5.9 μM for PAD4). Cl-amidine hydrochloride induces apoptosis in cancer cells and it also induces microRNA (miR)-16 in vitro ca...		Apoptosis , PAD
T11850	LIN28 inhibitor LI71
	LIN28 inhibitor LI71 is a potent and cell-permeable LIN28 inhibitor, which abolishes LIN28-mediated oligouridylation with an IC50 of 7 uM.
T16538	PIN1 inhibitor API-1		Others
	PIN1 inhibitor API-1 is a specific Pin1 inhibitor (IC50: 72.3 nM). PIN1 inhibitor API-1 retains the active conformation of pXPO5 and restores the ability of pXPO5 to transport pre-miRNAs from the nucleus to cytoplasm, th...		Others
T11851	Lin28-let-7a antagonist 1		Others
	Lin28-let-7a antagonist 1, with an IC50 of 4.03 μM for Lin28A-let-7a-1 interaction,and shows a clear antagonistic effect against the Lin28-let-7a interaction.		Others
T5S0246	Pseudoprotodioscin		Others , Fatty Acid Synthase
	1. Pseudoprotodioscin has moderate cytotoxicity.		Others , Fatty Acid Synthase
T1123	Camptothecin	NSC-100880,Campathecin,(S)-(+)-Camptothecin,CPT	Apoptosis , Influenza Virus , Topoisomerase , Antibiotic , Antifungal
	Camptothecin (CPT) belongs to the alkaloid group of natural products and is a specific DNA topoisomerase I (Topo I) inhibitor (IC50=679 nM) with specificity. Camptothecin has antitumor activity and induces apoptosis.
T8333	Aurintricarboxylic acid	ATA,NSC-4056,NSC4056,NSC 4056	Apoptosis , P2X Receptor , Influenza Virus , Topoisomerase
	Aurintricarboxylic acid (NSC-4056) is a strong inhibitor of topoisomerases and other nucleases. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme.		Apoptosis , P2X Receptor , Influenza Virus , Topoisomerase
T0717L	Enoxacin	NSC 629661,AT 2266,Pd107779,CI 919	DNA/RNA Synthesis , Topoisomerase , Antibacterial , Antibiotic
	Enoxacin (NSC-629661) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid.
T0717	Enoxacin hydrate	CI-919 hydrate,Enoxacin Sesquihydrate,AT-2266 hydrate	DNA gyrase , DNA/RNA Synthesis , Topoisomerase , Antibacterial , Antibiotic
	Enoxacin hydrate (AT-2266 hydrate) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent.
T16991	Targapremir-210	TGP-210	Apoptosis
	Targapremir-210 (TGP-210) is a selective and potent miRNA-210 (miRNA-210) inhibitor that inhibits pre-miR-210 processing and induces apoptosis in breast cancer cells.		Apoptosis
TN4171	Grossamide		NO Synthase
	Grossamide (GSE) Grossamide is a lignan amide derived from thioguanosine.6-Thioguanosine (GSE) is a selective and potent miR-210 (miRNA-210) inhibitor.6-Thioguanosine (GSE) is a selective and potent miR-210 (miRNA-210) i...		NO Synthase
T38680	RJW100		Others
	RJW100 is a compound that acts as a potent agonist of liver receptor homolog 1 (LRH-1, NR5A2) and steroidogenic factor-1 (SF-1, NR5A1), exhibiting pEC50 values of 6.6 and 7.5, respectively. Additionally, RJW100 induces r...		Others
T60420	Anticancer agent 73		DNA/RNA Synthesis
	Anticancer agent 73 is an anticancer agent which potently targets transactivation response(TAR) RNA-binding protein 2 (TRBP) and disrupts the TRBP-Dicer interaction. Anticancer agent 73 suppresses the growth and metasta...		DNA/RNA Synthesis
T24609	Thymidine 3',5'-disphosphate	Thymidine 3',5'-biphosphate,pdTp
	pdTp is a highly selective, small-molecule miRNA regulatory complex RISC subunit SND1 inhibitor.
T24744	Rubone
	Rubone is the tumor suppressor miRNA-34a modulator that acts by inhibiting the growth of hepatocellular carcinoma.
T81932	LIN28-IN-1
	LIN28-IN-1 (compound 5) is a selective inhibitor targeting the RNA-binding protein LIN28, specifically binding to its cold shock domain (CSD). This compound robustly interrupts the LIN28-let-7 miRNA interaction with an I...