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Lin28-let-7a antagonist 1

Catalog No. T11851   CAS 2024548-03-4

Lin28-let-7a antagonist 1, with an IC50 of 4.03 μM for Lin28A-let-7a-1 interaction,and shows a clear antagonistic effect against the Lin28-let-7a interaction.

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Lin28-let-7a antagonist 1 Chemical Structure
Lin28-let-7a antagonist 1, CAS 2024548-03-4
Pack Size Availability Price/USD Quantity
1 mg In stock $ 122.00
5 mg In stock $ 297.00
10 mg In stock $ 537.00
25 mg In stock $ 869.00
50 mg In stock $ 1,190.00
100 mg In stock $ 1,590.00
1 mL * 10 mM (in DMSO) In stock $ 393.00
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Purity: 99.91%
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Biological Description
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Storage & Solubility Information
Description Lin28-let-7a antagonist 1, with an IC50 of 4.03 μM for Lin28A-let-7a-1 interaction,and shows a clear antagonistic effect against the Lin28-let-7a interaction.
Targets&IC50 Lin28A-let-7a-1:4.03 μM
In vitro When the expression of both Lin28A and Lin28B are knocked-down using siRNA in JAR cells, the Lin28-let-7a antagonist 1-induced increase in cellular let-7 levels is clearly attenuated. Lin28A-let-7a-IN-1 increases mature let-7 levels in PA-1 cells that express high level of Lin28A. On the other hand, let-7 levels are not affected by 1 in MCF7 cells that rarely express Lin28 proteins. Taken together, Lin28-let-7a antagonist 1 specifically induces the increase in the cellular let-7 levels by targeting Lin28.Lin28-let-7a antagonist 1 shows a clear antagonistic effect against the Lin28A-let-7a-1 interaction with an IC50 of 4.03 μM.?Interestingly, Lin28-let-7a antagonist 1 also inhibits the Lin28B-let-7 interaction, with slightly reduced potency.?Dicer processing assay reveals that Lin28-let-7a antagonist 1 clearly blocks the formation of the Lin28A-pre-let-7g complex and induces miRNA processing, resulting in the generation of mature let-7g miRNA.?
Molecular Weight 583.59
Formula C31H29N5O7
CAS No. 2024548-03-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/ml (102.81 mM)

TargetMolReferences and Literature

1. Lim D, et al. Discovery of a Small-Molecule Inhibitor of Protein-MicroRNA Interaction Using Binding Assay with a Site-Specifically Labeled Lin28. J Am Chem Soc. 2016 Oct 7.

Related compound libraries

This product is contained In the following compound libraries:
Inhibitor Library Bioactive Compound Library Epigenetics Compound Library PPI Inhibitor Library Bioactive Compounds Library Max

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Keywords

Lin28-let-7a antagonist 1 2024548-03-4 Others Inhibitor inhibit MicroRNA Lin-28-let-7a antagonist 1 Lin28 let 7a antagonist 1 miRNA Lin28let7a antagonist 1 inhibitor

 

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