Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Lin28-let-7a antagonist 1, with an IC50 of 4.03 μM for Lin28A-let-7a-1 interaction,and shows a clear antagonistic effect against the Lin28-let-7a interaction.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 122.00 | |
5 mg | In stock | $ 297.00 | |
10 mg | In stock | $ 537.00 | |
25 mg | In stock | $ 869.00 | |
50 mg | In stock | $ 1,190.00 | |
100 mg | In stock | $ 1,590.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 393.00 |
Description | Lin28-let-7a antagonist 1, with an IC50 of 4.03 μM for Lin28A-let-7a-1 interaction,and shows a clear antagonistic effect against the Lin28-let-7a interaction. |
Targets&IC50 | Lin28A-let-7a-1:4.03 μM |
In vitro | When the expression of both Lin28A and Lin28B are knocked-down using siRNA in JAR cells, the Lin28-let-7a antagonist 1-induced increase in cellular let-7 levels is clearly attenuated. Lin28A-let-7a-IN-1 increases mature let-7 levels in PA-1 cells that express high level of Lin28A. On the other hand, let-7 levels are not affected by 1 in MCF7 cells that rarely express Lin28 proteins. Taken together, Lin28-let-7a antagonist 1 specifically induces the increase in the cellular let-7 levels by targeting Lin28.Lin28-let-7a antagonist 1 shows a clear antagonistic effect against the Lin28A-let-7a-1 interaction with an IC50 of 4.03 μM.?Interestingly, Lin28-let-7a antagonist 1 also inhibits the Lin28B-let-7 interaction, with slightly reduced potency.?Dicer processing assay reveals that Lin28-let-7a antagonist 1 clearly blocks the formation of the Lin28A-pre-let-7g complex and induces miRNA processing, resulting in the generation of mature let-7g miRNA.? |
Molecular Weight | 583.59 |
Formula | C31H29N5O7 |
CAS No. | 2024548-03-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/ml (102.81 mM)
You can also refer to dose conversion for different animals. More
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Lin28-let-7a antagonist 1 2024548-03-4 Others Inhibitor inhibit MicroRNA Lin-28-let-7a antagonist 1 Lin28 let 7a antagonist 1 miRNA Lin28let7a antagonist 1 inhibitor