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Targapremir-210

Catalog No. T16991 CAS 1049722-30-6

Synonyms: TGP-210

Targapremir-210 (TGP-210) is a selective and potent miRNA-210 (miRNA-210) inhibitor that inhibits pre-miR-210 processing and induces apoptosis in breast cancer cells.

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Targapremir-210, CAS 1049722-30-6

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1 mg	In stock	$ 232.00

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Chemical Properties

Storage & Solubility Information

Description	Targapremir-210 (TGP-210) is a selective and potent miRNA-210 (miRNA-210) inhibitor that inhibits pre-miR-210 processing and induces apoptosis in breast cancer cells.
Targets&IC50	miR-210:200 nM
In vitro	Targapremir-210 selectively reduces mature miR-210 levels in MDA-MB-231 cells under hypoxic conditions, achieving an IC50 of approximately 200 nM[1]. This compound specifically induces apoptosis in MDA-MB-231 cells exposed to hypoxia at 200 nM, while it does not trigger apoptosis in cells cultivated in normoxic environments[1].
In vivo	In vivo, a single intraperitoneal injection of Targapremir-210 (100 μL of 200 nM) impedes the proliferation of MDA-MB-231 triple-negative breast cancer (TNBC) cells. Targapremir-210 successfully reaches the tumor and sustains its presence throughout the entire 21-day period, leading to a reduction in tumor burden in a TNBC mouse model[1].

Synonyms	TGP-210
Molecular Weight	592.69
Formula	C32H36N10O2
CAS No.	1049722-30-6

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (168.72 mM), Sonication is recommended.

References and Literature

1. Costales MG, et al. Small Molecule Inhibition of microRNA-210 Reprograms an Oncogenic Hypoxic Circuit. J Am Chem Soc. 2017 Mar 8; 139(9):3446-3455.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Targapremir-210 1049722-30-6 Apoptosis Targapremir 210 Targapremir210 TGP-210 inhibitor inhibit

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