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Thymidine 3',5'-disphosphate

Catalog No. T24609 CAS 2863-04-9

Synonyms: Thymidine 3',5'-biphosphate, pdTp

pdTp is a highly selective, small-molecule miRNA regulatory complex RISC subunit SND1 inhibitor.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Thymidine 3',5'-disphosphate Chemical Structure

Thymidine 3',5'-disphosphate, CAS 2863-04-9

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

pdTp is a highly selective, small-molecule miRNA regulatory complex RISC subunit SND1 inhibitor.

Synonyms	Thymidine 3',5'-biphosphate, pdTp
Molecular Weight	402.19
Formula	C10H16N2O11P2
CAS No.	2863-04-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Jariwala N, Rajasekaran D, Mendoza RG, Shen XN, Siddiq A, Akiel MA, Robertson CL, Subler MA, Windle JJ, Fisher PB, Sanyal AJ, Sarkar D. Oncogenic Role of SND1 in Development and Progression of Hepatocellular Carcinoma. Cancer Res. 2017 Jun 15;77(12):3306-3316. doi: 10.1158/0008-5472.CAN-17-0298. Epub 2017 Apr 20. PubMed PMID: 28428278; PubMed Central PMCID: PMC5488274. 2. Lopez-Zavala AA, Sotelo-Mundo RR, Hernandez-Flores JM, Lugo-Sanchez ME, Sugich-Miranda R, Garcia-Orozco KD. Arginine kinase shows nucleoside diphosphate kinase-like activity toward deoxythymidine diphosphate. J Bioenerg Biomembr. 2016 Jun;48(3):301-8. doi: 10.1007/s10863-016-9660-1. Epub 2016 Apr 12. PubMed PMID: 27072556. 3. Wang CC, Tsong TY, Hsu YH, Marszalek PE. Inhibitor binding increases the mechanical stability of staphylococcal nuclease. Biophys J. 2011 Feb 16;100(4):1094-9. doi: 10.1016/j.bpj.2011.01.011. Erratum in: Biophys J. 2011 Mar 16;100(6):1596. PubMed PMID: 21320455; PubMed Central PMCID: PMC3037565. 4. Sunil S, Hossain MJ, Ramasamy G, Malhotra P. Transient silencing of Plasmodium falciparum Tudor Staphylococcal Nuclease suggests an essential role for the protein. Biochem Biophys Res Commun. 2008 Jul 25;372(2):373-8. doi: 10.1016/j.bbrc.2008.05.033. Epub 2008 May 16. PubMed PMID: 18486605.

Dose Conversion

You can also refer to dose conversion for different animals. More

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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The answer of 19.713 mg appears in the Mass box

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The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Thymidine 3',5'-disphosphate 2863-04-9 Thymidine 3',5'-biphosphate Thymidine 3',5'disphosphate pdTp Thymidine 3',5' disphosphate inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.