messenger — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T8461	SKI V		Apoptosis , PI3K , S1P Receptor
	SKI V is a potent and noncompetitive non-lipid sphingosine kinase (SPHK; SK) inhibitor (GST-hSK,IC50 : 2 μM), and is a PI3K inhibitor(hPI3k,IC50 : 6 μM), induces apoptosis and has antitumor activity		Apoptosis , PI3K , S1P Receptor
T4950	1,2-Dipalmitoyl-sn-glycerol	(S)-1,2-Dipalmitin	Endogenous Metabolite , PKC
	1,2-Dipalmitoyl-sn-glycerol ((S)-1,2-Dipalmitin) is an analog of the PKC-activating second messenger diacylglycerol (DAG). It weakly activates PKC.		Endogenous Metabolite , PKC
T8404	Kasugamycin hydrochloride hydrate	Ksg (hydrochloride hydrate)	Antibacterial , Antibiotic
	Kasugamycin hydrochloride hydrate (Ksg (hydrochloride hydrate))(Ksg) specifically inhibits translation initiation of canonical but not of leaderless messenger RNAs. Ksg inhibition is thought to occur by direct competitio...		Antibacterial , Antibiotic
T10107	3-Bromo-7-nitroindazole		NOS
	3-Bromo-7-nitroindazole is a more potent and selective inhibitor of neuronal nitric oxide synthase (nNOS) than eNOS or iNOS. It affects the intercellular messenger NO synthesis throughout the brain and body.		NOS
T10065L	2',3'-cGAMP sodium	2'-3'-cyclic GMP-AMP sodium	STING , cGAS
	2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium), a cGAMP synthase (cGAS) affecting cytoplasmic DNA production as a second messenger, is a transmembrane bridging protein that is a key component of the cellular innate imm...		STING , cGAS
T36983	Cyclic-di-GMP disodium	Cyclic diguanylate,5GP-5GP disodium,3',5'-Cyclic diguanylic acid,Cyclic di-GMP (sodium salt),cyclic diguanylate disodium,c-di-GMP,c-di-GMP disodium	STING , Endogenous Metabolite
	Cyclic-di-GMP disodium (5GP-5GP disodium) is a bacterial second messenger and a STING agonist involved in a variety of prokaryotic processes including biofilm formation, motility, and cell cycle progression.Cyclic-di-GMP...		STING , Endogenous Metabolite
T5065	GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SOD	Monosodium-GMP,cGMP sodium salt,Cyclic GMP	PKA
	GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SOD (cGMP sodium salt) , also known as cGMP, is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, inc...		PKA
T24023	E7107	E-7107,E 7107
	E7107 is a first-in-class inhibitor of precursor messenger ribonucleic acid spliceosome.
T10909	Cyclic-di-GMP	c-di-GMP,cyclic diguanylate,5GP-5GP	Others
	Cyclic-di-GMP is a STING agonist and ubiquitous second messenger, which regulates the formation, motility and virulence of biofilms in various bacterial species.		Others
T13606	CGAMP	3',3'-cGAMP,Cyclic GMP-AMP	Others
	cGAMP is an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. It also is a STING ligand.		Others
T19266	Ins(1,4,5)-P3 hexapotassium salt	1,4,5-IP3 hexapotassium salt,D-myo-Inositol 1,4,5-trisphosphate hexapotassium salt	Others
	D-myo-Inositol 1,4,5-trisphosphate hexapotassium salt is promotes endoplasmic The second messenger of net calcium ions.		Others
T38656	Nusinersen
	Nusinersen, an antisense oligonucleotide drug, modifies the pre-messenger RNA (pre-mRNA) splicing of the SMN2 gene, thereby enhancing the production of the full-length Survival Motor Neuron (SMN) protein.
T19253	Cyclic ADP-ribose	cADPR	Calcium Channel
	Cyclic ADP-ribose (cADPR) is an effective calcium mobilization second messenger, which is synthesized from NAD + by ADP-ribosyl cyclase. Cyclic ADP-ribose mainly increases cytosolic calcium through Ryanodine receptor-med...		Calcium Channel
T38986	Fitusiran	ALN-AT3SC,SAR439774
	Fitusiran (ALN-AT3SC) is a small interfering RNA compound designed to selectively bind to antithrombin (AT) messenger RNA in the liver, leading to decreased AT production. By doing so, Fitusiran enhances thrombin generat...
T74970	306Oi10
	306Oi10, a branched-chain ionizable lipidoid, facilitates the construction of lipid nanoparticles (LNPs) for messenger RNA delivery [1].
T27157	Dezapelisib	INCB-040093,INCB 040093,INCB040093
	Dezapelisib is an orally bioavailable, selective inhibitor of the delta isoform of the 110 kDa catalytic subunit of class I phosphoinositide-3 kinases (PI3K). INCB040093 prevents both the production of the second messeng...
T37687	Cyclic ADP-ribose ammonium
	Cyclic ADP-ribose ammonium (cADPR ammonium) is a powerful calcium mobilization second messenger synthesized from NAD+ by an ADP-ribosyl cyclase. It primarily raises cytosolic calcium levels through Ryanodine receptor-med...
T38804	Patisiran sodium
	Patisiran sodium is a double-stranded small interfering RNA (siRNA) that selectively targets a specific sequence within the transthyretin (TTR) messenger RNA (mRNA). By doing so, it effectively blocks the hepatic synthes...
T39123	Givosiran	ALN-AS1,Givosiran
	Givosiran (ALN-AS1) is a small interfering RNA (siRNA) compound that specifically targets hepatic aminolevulinate synthase 1 (ALAS1) messenger RNA (mRNA) to downregulate its expression. By doing so, Givosiran effectively...
T72243	Cyclic-di-GMP diammonium	5GP-5GP diammonium,c-di-GMP diammonium ; cyclic diguanylate diammonium ; 5GP-5GP diammonium,c-di-GMP diammonium,cyclic diguanylate diammonium
	Cyclic di-GMP (c-di-GMP) diammonium is a STING activator and a global bacterial second messenger, which regulates biofilm formation, motility, and virulence in diverse bacterial species .