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3-Bromo-7-nitroindazole

Catalog No. T10107 CAS 74209-34-0

3-Bromo-7-nitroindazole is a specific neuronal nitric oxide synthase (nNOS) inhibitor. It affects the intercellular messenger NO synthesis throughout the brain and body.

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3-Bromo-7-nitroindazole Chemical Structure

3-Bromo-7-nitroindazole, CAS 74209-34-0

Pack Size	Availability	Price/USD
10 mg	In stock	$ 39.00
25 mg	In stock	$ 70.00
50 mg	In stock	$ 122.00
100 mg	In stock	$ 198.00
200 mg	In stock	$ 297.00
500 mg	In stock	$ 511.00
1 mL * 10 mM (in DMSO)	In stock	$ 43.00

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Biological Description

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Description

3-Bromo-7-nitroindazole is a specific neuronal nitric oxide synthase (nNOS) inhibitor. It affects the intercellular messenger NO synthesis throughout the brain and body.

In vivo

Male rats received either 3-Bromo-7-nitroindazole (20mg/kg/day) or saline via intraperitoneal injection for 5days. Daily administration of the specific neuronal nitric oxide synthase (nNOS) inhibitor, 3-Bromo-7-nitroindazole impaired the acquisition of the Morris water maze (MWM) paradigm task. 3-Bromo-7-nitroindazole also impaired the probe trial. The MWM training was associated with a significant increase in the brain-derived neurotrophic factor (BDNF) mRNA expression in the hippocampus. BDNF mRNA expression in the hippocampus did not change after 3-Bromo-7-nitroindazole treatment. L-arginine significantly reversed behavioural parameters, and the effect of 3-Bromo-7-nitroindazole was found to be NO-dependent. There were no differences in locomotor activity and blood pressure in 3-Bromo-7-nitroindazole treated rats[1].

Molecular Weight	242.03
Formula	C7H4BrN3O2
CAS No.	74209-34-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (413.17 mM)

References and Literature

1. Gocmez SS, et al. The effect of a selective neuronal nitric oxide synthase inhibitor 3-bromo 7-nitroindazoleon spatial learning and memory in rats. Pharmacol Biochem Behav. 2015 Apr;131:19-25.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compounds Library Max Bioactive Compound Library Immunology/Inflammation Compound Library

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Keywords

3-Bromo-7-nitroindazole 74209-34-0 Immunology/Inflammation NOS 3Bromo7nitroindazole inhibit NO Synthase Nitric oxide synthases Inhibitor 3 Bromo 7 nitroindazole inhibitor

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