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Search Results for " mitf "

Targets

5

Compounds

10

Natural Products

2

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T4028 ML329 TRP/TRPV Channel
ML329 is a small molecule inhibitor of MITF, inhibiting TRPM-1 promoter activity.
T77743 TT-012 Others
TT-012 has anti-tumor activity, selectively binds dynamic MITF and disrupts the dimer formation and DNA binding of the latter. TT-012 can inhibit the transcription of MITF in B16F10 melanoma cells. TT-012 inhibited the g...
TP2487 Oligopeptide-68 Acetate Oligopeptide-68 Acetate(1206525-47-4 Free base) Others
Oligopeptide-68 Acetate is a peptide. It is a novel whitening ingredient that mimics the binding of TGF-β to cell surface receptors to reduce induced and hereditary pigmentation by inhibiting MITF intramolecular channels...
T76597 Prolylserine
Prolylserine, a dipeptide, acts as a melanogenesis inhibitor in Mel-Ab cells by reducing microphthalmia-associated transcription factor (MITF) and tyrosinase expression, inducing phosphorylation of ERK, but not affecting...
T75535 5-epi-Arvestonate A
5-epi-Arvestonate A, a sesquiterpenoid extracted from Seriphidium transiliense whole plants, enhances melanogenic production by stimulating MITF and tyrosinase family gene transcription. Additionally, it suppresses IFN-γ...
Cat No. Product Name Synonyms Targets
T2P2810 Methyl Linoleate Linoleic acid methyl ester,Telfairic Acid methyl ester Antioxidant
Methyl Linoleate (Telfairic Acid methyl ester) linoleate has antioxidant activity.
T3676 Sesamol 1,3-Benzodioxol-5-ol,3,4-Methylenedioxyphenol Apoptosis , AMPK
Sesamol (1,3-Benzodioxol-5-ol) could decrease lung inflammation and lipopolysaccharide (LPS)-induced lung injury in rats. Sesamol ameliorates inflammatory and oxidative damage by upregulating AMPK activation and Nrf2 sig...
TN2246 Swertiajaponin Tyrosinase
Swertiajaponin possesses antimicrobial activity.
T13762 Luteolin 7-sulfate Others
Luteolin 7-sulfate, derived from the marine plant Phyllospadix iwatensis Makino, suppresses TYR gene expression by intervening in a signaling pathway involving the cAMP-responsive element binding protein (CREB) and micro...
TN4179 Haginin A ERK , Tyrosinase , Akt
Haginin A is an effective inhibitor of hyperpigmentation caused by UV irradiation or by pigmented skin disorders through downregulation via ERK and Akt/PKB activation, MITF, and also by the subsequent downregulation of t...
TN4468 (-)-Lyoniresinol 9'-O-glucoside Others
(-)-Lyoniresinol 9'-O-glucoside is a natural product from Phyllostachys heterocycla MITF.
T75506 6-Acetylnimbandiol
6-Acetylnimbandiol (6-O-Acetylnimbandiol), a non-cytotoxic tyrosinase inhibitor (IC 50 = 69.85 μM), effectively inhibits melanin production and MITF expression, making it valuable for melanoma research [1].
TMA0003 Trans-caffeic acid cAMP , Tyrosinase
Trans-caffeic acid stearyl ester is posited to inhibit melanogenesis signaling while suppressing cAMP levels and, subsequently, MC1R, MITF, tyrosinase, TRP-2 and TRP-1 down-regulation, resulting in the suppression of tyr...
T79996 N,N′-Diferuloylputrescine Melanocortin Receptor
N,N′-Diferuloylputrescine acts as a pigment inhibitor, showing a 57% reduction in pigmentation. It also considerably diminishes the protein expression of MITF and displays potent antioxidant properties as a radical scave...
TN4489 Manassantin A ERK , cAMP , TNF , NF-κB , MAPK , COX , HIF , Prostaglandin Receptor , JNK , STAT
Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effects might be associated with COX/PGE2 stimulation, inhibitio...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPJ-01173 TFF3 Protein, Mouse, Recombinant (His) Mouse HEK293 Cells
Trefoil factors (TFF) are secretory products of mucin producing cells. They play a key role in the maintenance of the surface integrity of oral mucosa and enhance healing of the gastrointestinal mucosa by a process calle...
TMPJ-00281 CADM1 Protein, Mouse, Recombinant (hFc) Mouse HEK293 Cells
Cell adhesion molecule 1(CADM1) is a single-pass type I membrane protein and belongs to the nectin family. It contains 2 Ig-like C2-type (immunoglobulin-like) domains and 1 Ig-like V-type (immunoglobulin-like) domain. C...
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