glucose-dependent — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T15656	KGA-2727		SGLT
	KGA-2727 is a potent and selective SGLT1 inhibitor, with Kis of 97.4 nM and 43.5 nM for human and rat SGLT1, respectively. The selectivity ratios (Ki for SGLT2/Ki for SGLT1) of KGA-2727 are 140 (human) and 390 (rat). KGA...		SGLT
T38843	Enavogliflozin	DWP-16001	SGLT
	Enavogliflozin (DWP-16001) is an orally available small molecule and sodium glucose transporter 2 inhibitor.		SGLT
T9590	T-1095		SGLT , transporter
	T-1095 is an inhibitor of renal glucose reabsorption and the expression of Na+-glucose cotransporters (SGLTs) and facilitative glucose transporter 2 (GLUT2).		SGLT , transporter
T1766	Empagliflozin	BI 10773	SGLT
	Empagliflozin (BI 10773) is an SGLT-2 inhibitor (IC50=3.1 nM) that is potent and selective, with more than 300-fold selectivity for SGLT-1/4/5/6. Empagliflozin is used for the treatment of type 2 diabetes.		SGLT
T2385	Ipragliflozin	ASP1941	SGLT
	Ipragliflozin (ASP1941) is under investigation in Type 2 Diabetes and Diabetes Mellitus, Type 2.		SGLT
T2389	Dapagliflozin	BMS-512148	SGLT , HIF
	Dapagliflozin (BMS-512148) is a selective sodium-glucose co-transporter subtype 2 (SGLT2) inhibitor with antihyperglycemic activity.		SGLT , HIF
T2924	Phloretin	Dihydronaringenin,NSC 407292,RJC 02792	SGLT , transporter , Endogenous Metabolite
	Phloretin (NSC-407292) is a well-known inhibitor of eukaryotic urea transporters, blocks VacA-mediated urea and ion transport. Phloretin is a dihydrochalcone, a type of natural phenols. It can be found in apple tree leav...		SGLT , transporter , Endogenous Metabolite
T3547	Sotagliflozin	LX-4211,LP-802034	SGLT
	Sotagliflozin (LP-802034) is an orally bioavailable inhibitor of the sodium-glucose co-transporter subtype 1 (SGLT1) and 2 (SGLT2), with potential antihyperglycemic activity.		SGLT
TN7108	Urolithin C		Apoptosis , Calcium Channel , Reactive Oxygen Species , IGF-1R , Endogenous Metabolite
	Urolithin C is a gut metabolite of ellagic acid. Urolithin C induces apoptosis in PC12 cells through a mitochondria-mediated pathway.
T4999	Ertugliflozin	MK-8835,PF-04971729	SGLT
	PF-04971729 (Ertugliflozin (PF-04971729)) is a potent and selective inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2).		SGLT
T2S0731	Trilobatin	P-Phlorizin	Amylase
	Trilobatin (P-Phlorizin) has anti-oxidant effect, can increase superoxide dismutase (SOD) activity.Trilobatin has anti-inflammatory effect, it potentially inhibits the lipopolysaccharide (LPS)-induced inflammatory respon...		Amylase
T2922	Phlorizin	Floridzin,NSC 2833,Phloridzin	ATPase , SGLT
	Phlorizin (Phloridzin) is a non-selective SGLT inhibitor found in apple, for hSGLT1( Ki=300 nM) and hSGLT2( Ki=39 nM) .		ATPase , SGLT
T15244	Ertugliflozin L-pyroglutamic acid	PF-04971729 L-pyroglutamic acid	Others , SGLT
	Ertugliflozin L-pyroglutamic acid (PF-04971729 L-pyroglutamic acid) is a selective and orally active hSGLT2 inhibitor with an IC50 of 0.877 nM. Ertugliflozin L-pyroglutamic acid can be used for studies about the treatmen...		Others , SGLT
T5016	Tofogliflozin (hydrate)	Tofogliflozin hydrate,CSG-452 hydrate	SGLT , Reactive Oxygen Species , ROS
	Tofogliflozin hydrate (CSG-452 hydrate) is a potent and highly specific inhibitor of SGLT2(IC50 of 2.9 nM and Ki values of 2.9 nM, 14.9 nM, and 6.4 nM for human, rat, and mouse SGLT2).		SGLT , Reactive Oxygen Species , ROS
T83710	Gastric Inhibitory Peptide (22-51) (human) TFA	GIP (22-51),Glucose-dependent Insulinotropic Peptide (22-51)
	Gastric inhibitory peptide (GIP) (22-51), a pro-atherogenic peptide comprised of 30 amino acids from the residues 22-51 of its precursor protein proGIP, is present in human plasma. It activates the degradation of IκB-α a...
T83694	Gastric Inhibitory Peptide (1-42) (porcine) TFA	GIP (1-42),Glucose-dependent Insulinotropic Polypeptide (1-42)
	Gastric inhibitory peptide (GIP) (1-42), an endogenous incretin hormone comprising 42 amino acids, promotes insulin secretion. Expressed in the intestinal neuroendocrine K cells and submandibular gland, it enters circula...
T1782	Canagliflozin	JNJ 24831754ZAE,JNJ 28431754AAA,TA 7284,JNJ 28431754	SGLT
	Canagliflozin (JNJ 28431754AAA), a sodium-glucose transporter 2( SGLT2) and P-Glycoprotein inhibitor, is used in type 2 diabetes.		SGLT
T83696	Gastric Inhibitory Peptide 1 (3-42) (human) TFA	Glucose-dependent Insulinotropic Polypeptide 3-42,GIP-1 (3-42)
	Gastric inhibitory peptide 1 (GIP-1) (3-42), a fragment of the incretin hormone GIP and antagonist to the GIP receptor, is generated through the action of serum dipeptidyl peptidase 4 (DDP-4). When administered at 25 nmo...
T4460	Dapagliflozin ((2S)-1,2-propanediol, hydrate)	BMS-512148 (2S)-1,2-propanediol, hydrate,Dapagliflozin propanediol monohydrate	SGLT
	Dapagliflozin ((2S)-1,2-propanediol, hydrate) (BMS-512148 (2S)-1,2-propanediol, hydrate) is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2). It is in development for the tre...		SGLT
T15752	Licogliflozin	LIK066	SGLT
	Licogliflozin (LIK066) is an inhibitor of sodium-glucose cotransporter (SGLT1 and SGLT2).		SGLT