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Ertugliflozin

Catalog No. T4999 CAS 1210344-57-2

Synonyms: MK-8835, PF-04971729

PF-04971729 (Ertugliflozin (PF-04971729)) is a potent and selective inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2).

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Ertugliflozin, CAS 1210344-57-2

Pack Size	Availability	Price/USD
5 mg	In stock	$ 45.00
10 mg	In stock	$ 63.00
50 mg	In stock	$ 97.00
100 mg	In stock	$ 148.00
200 mg	In stock	$ 238.00
500 mg	In stock	$ 392.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.89%

Purity: 99.27%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	PF-04971729 (Ertugliflozin (PF-04971729)) is a potent and selective inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2).
Targets&IC50	SGLT2 (human):0.877 nM

Synonyms	MK-8835, PF-04971729
Molecular Weight	436.88
Formula	C22H25ClO7
CAS No.	1210344-57-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 46 mg/mL (105.29 mM)

References and Literature

1. Mascitti V, et al. Discovery of a clinical candidate from the structurally unique dioxa-bicyclo[3.2.1]octane class of sodium-dependent glucose cotransporter 2 inhibitors. J Med Chem. 2011 Apr 28;54(8):2952-60. 2. Kalgutkar AS, et al. Preclinical species and human disposition of PF-04971729, a selective inhibitor of the sodium-dependent glucose cotransporter 2 and clinical candidate for the treatment of type 2 diabetes mellitus. Drug Metab Dispos. 2011 Sep;39(9):16 3. Miao Z, et al. Pharmacokinetics, metabolism, and excretion of the antidiabetic agent ertugliflozin (PF-04971729) in healthy male subjects. Drug Metab Dispos. 2013 Feb;41(2):445-56.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library GPCR Compound Library Inhibitor Library Anti-Cancer Clinical Compound Library EMA Approved Drug Library Anti-Cancer Approved Drug Library Drug Repurposing Compound Library Highly Selective Inhibitor Library Membrane Protein-targeted Compound Library Bioactive Compound Library

Related Products

Related compounds with same targets

HSK0935 Bexagliflozin Phlorizin Canagliflozin Canagliflozin hemihydrate Remogliflozin etabonate Enavogliflozin LY2794193

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Ertugliflozin 1210344-57-2 GPCR/G Protein SGLT MK8835 inhibit MK-8835 MK 8835 Inhibitor PF04971729 PF 04971729 Sodium-dependent glucose cotransporters PF-04971729 inhibitor

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