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Ertugliflozin L-pyroglutamic acid

Catalog No. T15244   CAS 1210344-83-4
Synonyms: PF-04971729 L-pyroglutamic acid

Ertugliflozin L-pyroglutamic acid (PF-04971729 L-pyroglutamic acid) is a selective and orally active hSGLT2 inhibitor with an IC50 of 0.877 nM. Ertugliflozin L-pyroglutamic acid can be used for studies about the treatment of type 2 diabetes mellitus.

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Ertugliflozin L-pyroglutamic acid Chemical Structure
Ertugliflozin L-pyroglutamic acid, CAS 1210344-83-4
Pack Size Availability Price/USD Quantity
5 mg In stock $ 39.00
10 mg In stock $ 55.00
25 mg In stock $ 82.00
50 mg In stock $ 97.00
100 mg In stock $ 143.00
200 mg In stock $ 209.00
500 mg In stock $ 358.00
1 mL * 10 mM (in DMSO) In stock $ 48.00
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Purity: 98.71%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Ertugliflozin L-pyroglutamic acid (PF-04971729 L-pyroglutamic acid) is a selective and orally active hSGLT2 inhibitor with an IC50 of 0.877 nM. Ertugliflozin L-pyroglutamic acid can be used for studies about the treatment of type 2 diabetes mellitus.
Targets&IC50 SGLT2 (human):0.877 nM
In vitro Ertugliflozin L-pyroglutamic acid demonstrated >2000-fold selectivity for SGLT2 over SGLT[2].
In vivo The oral administration of Ertugliflozin L-pyroglutamic to rats acid showed concentration-dependent glucosuria[2].
Synonyms PF-04971729 L-pyroglutamic acid
Molecular Weight 566
Formula C27H32ClNO10
CAS No. 1210344-83-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 125 mg/mL (220.85 mM)

TargetMolReferences and Literature

1. Miao Z, et al. Pharmacokinetics, metabolism, and excretion of the antidiabetic agent ertugliflozin (PF-04971729) in healthy male subjects. Drug Metab Dispos. 2013 Feb;41(2):445-56. 2. Kalgutkar AS, et al. Preclinical species and human disposition of PF-04971729, a selective inhibitor of the sodium-dependent glucose cotransporter 2 and clinical candidate for the treatment of type 2 diabetes mellitus. Drug Metab Dispos. 2011 Sep;39(9):1609-19. 3. Mascitti V, et al. Discovery of a clinical candidate from the structurally unique dioxa-bicyclo[3.2.1]octane class of sodium-dependent glucose cotransporter 2 inhibitors. J Med Chem. 2011 Apr 28;54(8):2952-60.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Drug Library Anti-Cancer Approved Drug Library EMA Approved Drug Library Membrane Protein-targeted Compound Library Drug Repurposing Compound Library Inhibitor Library GPCR Compound Library Anti-Cancer Clinical Compound Library FDA-Approved Drug Library Bioactive Compound Library

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Picraline Ertugliflozin Canagliflozin hemihydrate Dapagliflozin ((2S)-1,2-propanediol, hydrate) LY2794193 Leachianone A T-1095 KGA-2727

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Keywords

Ertugliflozin L-pyroglutamic acid 1210344-83-4 GPCR/G Protein Others SGLT inhibit Sodium-dependent glucose cotransporters Inhibitor Ertugliflozin L pyroglutamic acid PF-04971729 L-pyroglutamic acid Ertugliflozin Lpyroglutamic acid inhibitor

 

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