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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T3133 | YM-90709 | YM90709,YM 90709 | IL Receptor , Interleukin |
YM-90709 is a new-type antagonist inhibiting the binding of interleukin-5 to the interleukin-5 receptor. | |||
T8462 | Enoximone | PDE | |
Enoximone is a selective inhibitor of phosphodiesterase III (PDE3), with treatment of congestive heart failure. | |||
T1083 | Theophylline | Theo-24,1,3-Dimethylxanthine | Endogenous Metabolite , HDAC , PDE , Adenosine Receptor , Autophagy |
Theophylline (1,3-Dimethylxanthine) is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Theophylline inhibits the 3... | |||
T1083L | Theophylline monohydrate | Quibron | HDAC , PDE , Adenosine Receptor |
Theophylline monohydrate (Quibron) appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distribution, and antagonize adenosine. Theophylline monohydrate is a ... | |||
T10497 | Benralizumab | BIW-8405,MEDI-563 | Apoptosis , IL Receptor , Interleukin |
Benralizumab (MEDI-563) is a monoclonal antibody targeting the interleukin-5 receptor alpha (IL-5Rα). It enhances antibody-dependent cell-mediated cytotoxicity, leading to a rapid depletion of eosinophils. Benralizumab i... | |||
T30819 | CGP 20376 | CGP-20376,CGP20376 | |
CGP 20376 is a benzothiazole compound, an anthelmintic, with dual dose-dependent modulation of in vitro effects on the respiratory burst of eosinophils and antifibrillatory properties. | |||
T3520 | Setipiprant | KYTH-105,ACT-129968 | GPR , Prostaglandin Receptor |
Setipiprant (ACT-129968) is an orally available, selective CRTH2 antagonist (IC50: 6.0 nM). CRTH2 is a G protein-coupled receptor for prostaglandin (PGD2). PGD2 is produced by the mast cells and is a key mediator in vari... | |||
T31719 | Etiprednol dicloacetate | BNP 166,BNP166,BNP-166 | Others |
Etiprednol dicloacetate (BNP-166) is a corticosteroid with anti-inflammatory activity.Etiprednol dicloacetate inhibits the accumulation of eosinophils and can be used in the study of inflammatory airway diseases such as ... | |||
T22879 | JNJ 10191584 maleate | JNJ 10191584 maleate salt,VUF6002 maleate | Histamine Receptor |
JNJ 10191584 maleate (VUF6002 maleate) is an orally active and selective antagonist of H4 receptor (Ki = 26 nM). JNJ 10191584 maleate inhibits chemotaxis of eosinophils and mast cells (IC50 = 530 nM and 138 nM). | |||
TP1597L | Secretoneurin, rat acetate | Secretoneurin, rat acetate(149146-12-3 Free base) | Others |
Secretoneurin, rat acetate is a 33-amino acid polypeptide generated by proteolytic processing of secretogranin II (SgII). Secretoneurin, rat acetate induces dopamine release in the rat striatum in vivo and in vitro, and ... | |||
T4674 | SB297006 | SB 297006 | CCR |
SB297006 is an antagonist of C-C chemokine receptor 3 (CCR3; IC50 = 39 nM), which normally is activated by eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1δ. It is at least 250-fold selective for CCR3 over a panel of ... | |||
T26470 | A1777 | AA1777,AA-1777,AA 1777 | |
A1777, a selective 5-lipoxygenase inhibitor, reduces leukocytes proliferation without affecting the eosinophils of mast cells. | |||
T15565 | Imetit dihydrobromide | VUF 8325 dihydrobromide,SKF 91105 dihydrobromide | Histamine Receptor |
Imetit dihydrobromide is a high affinity and effective agonist of histamine H3 and H4 receptors (Ki: 0.3 and 2.7 nM). Imetit mimics the histamine effect in triggering a shape change in eosinophils (EC50: 25 nM). | |||
T17099 | Timapiprant sodium | OC000459 sodium | Others |
Timapiprant sodium inhibits mast cell activation of Th2 lymphocytes and eosinophils. Timapiprant sodium is a potent and selective D prostanoid receptor 2 antagonist. Timapiprant sodium potently displaces [3H] PGD2 from h... | |||
T68474 | RWJ-58643 HCl | ||
RWJ 58643 is a reversible beta-tryptase and trypsin inhibitor. Low-dose RWJ-58643 (100 microg) and budesonide (200 microg) significantly reduced symptoms, eosinophils and levels of IL-5 following NAC. However, higher dos... | |||
T37650 | 5(S),15(S)-DiHETE | ||
5(S),15(S)-DiHETE is synthesized by 15-LO from 5(S)-HETE. It potentiates the degranulation of human PMNL in response to PAF, but not fMLP, calcium ionophore A23187, or LTB4. 5(S),15(S)-DiHETE is chemotactic for eosinophi... | |||
T80882 | Val-Gly-Ser-Glu | NSC 350591 | |
Val-Gly-Ser-Glu (NSC 350591), an ECF-A tetrapeptide, dose-dependently enhances the rosetting of human eosinophils with complement-coated sheep erythrocytes (EAC3b) without affecting neutrophils [1]. | |||
T60366 | Epinastine | ||
Epinastine (WAL801), a potent, selective, and orally-active antihistamine and mast cell stabilizer, functions as a histamine H1 receptor antagonist. It also inhibits IL-8 release from human eosinophils, showcasing antial... | |||
T37303 | 5-OxoETE | 5-KETE,5-OxoETE | |
5-OxoETE is a polyunsaturated keto acid formed by the oxidation of 5-HETE in human neutrophils by a specific dehydrogenase.[1] It stimulates cytosolic calcium levels in neutrophils with an EC50 value of 2 nM.[2] 5-OxoETE... | |||
T62604 | Flunisolide hemihydrate | ||
Flunisolide hemihydrate is a corticosteroid, an orally active Glucocorticoid receptor activator with anti-inflammatory effects. flunisolide hemihydrate induces apoptosis in eosinophils and can be used in asthma or rhinit... |