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CGP 20376

Catalog No. T30819 CAS 81059-04-3

Synonyms: CGP-20376, CGP20376

CGP 20376 is a benzothiazole compound, an anthelmintic, with dual dose-dependent modulation of in vitro effects on the respiratory burst of eosinophils and antifibrillatory properties.

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CGP 20376, CAS 81059-04-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 300.00
5 mg	In stock	$ 735.00
10 mg	In stock	$ 987.00
25 mg	In stock	$ 1,530.00
50 mg	In stock	$ 1,980.00

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Purity: 91.37%

Biological Description

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Description	CGP 20376 is a benzothiazole compound, an anthelmintic, with dual dose-dependent modulation of in vitro effects on the respiratory burst of eosinophils and antifibrillatory properties.
In vitro	CGP 20376 (1 micron/ml) reduction of motility of 98-100% after 24 hours of exposure occurred at levels. After exposure for 1 h CGP 20376 immobilized 100% of the microfilariae irreversibly at a drug level of 1 microgram/ml. Whereas no significant immobilization was seen with CGP 6140 after one hour.[5]
In vivo	CGP 20376 (20 mg/kg orally) had a rapid and profound reduction, but by 137 d.p.t. microfilarial skin densities were approaching pre-treatment levels. By 137 d.p.t. embryogenesis was almost completely interrupted in the CGP 20376 treated animals and the majority of remaining intrauterine microfilariae were pathologically altered.[1]

Synonyms	CGP-20376, CGP20376
Molecular Weight	384.54
Formula	C16H20N2O3S3
CAS No.	81059-04-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Renz A, et al. Evaluation of suramin, ivermectin and CGP 20376 in a new macrofilaricidal drug screen, Onchocerca ochengi in African cattle. Trop Med Parasitol. 1995 Mar;46(1):31-7. 2. Tischendorf FW, et al. Modulatory effects of antifilarial drugs ivermectin, CGP 6140 and CGP 20376 on the oxidative burst of eosinophilic granulocytes. Acta Trop. 1993 Mar;53(1):27-37. 3. Chandrashekar R, et al. Effect of CGP 20376 on Brugia malayi and parasite antigenemia in jirds. J Parasitol. 1991 Jun;77(3):479-82. 4. Mak JW, et al. Antifilarial activity of CGP 20376 against subperiodic Brugia malayi in the leaf-monkey Presbytis cristata. Trop Med Parasitol. 1990 Mar;41(1):10-2. 5. Strote G. In vitro study on the effect of the new chemotherapeutic agents CGP 6140 and CGP 20376 on the microfilariae of Onchocerca volvulus. Trop Med Parasitol. 1987;38(3):211-213.

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Keywords

CGP 20376 81059-04-3 CGP-20376 CGP20376 inhibitor inhibit

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