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Etiprednol dicloacetate

Catalog No. T31719 CAS 199331-40-3

Synonyms: BNP 166, BNP166, BNP-166

Etiprednol dicloacetate (BNP-166) is a corticosteroid with anti-inflammatory activity.Etiprednol dicloacetate inhibits the accumulation of eosinophils and can be used in the study of inflammatory airway diseases such as asthma and in the treatment of Crohn's disease.

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Etiprednol dicloacetate Chemical Structure

Etiprednol dicloacetate, CAS 199331-40-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 112.00
5 mg	In stock	$ 260.00
10 mg	In stock	$ 390.00
25 mg	In stock	$ 653.00
50 mg	In stock	$ 928.00
100 mg	In stock	$ 1,260.00

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Purity: 99.43%

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Description	Etiprednol dicloacetate (BNP-166) is a corticosteroid with anti-inflammatory activity.Etiprednol dicloacetate inhibits the accumulation of eosinophils and can be used in the study of inflammatory airway diseases such as asthma and in the treatment of Crohn's disease.
In vitro	Etiprednol dicloacetate (1 nM-1 μM) Inhibition of LPS-induced TNF-α production in human blood.[1]
In vivo	Etiprednol dicloacetate (0-100 μg/kg; intranasal inhalation) reduces peribronchial eosinophilia in the lungs of allergen-sensitized and challenged rats.[1] Etiprednol dicloacetate (0-20 mg/kg; p.o.; 28 days) is well tolerated in rats and dogs.[2] Etiprednol dicloacetate (0.1 μg/kg; intranasal inhalation) inhibits eosinophil accumulation in rats (eosinophilic infiltration induced by antigen exposure).[3]

Synonyms	BNP 166, BNP166, BNP-166
Molecular Weight	485.4
Formula	C24H30Cl2O6
CAS No.	199331-40-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (113.31 mM)

References and Literature

1. Kurucz I, et al. Potency and specificity of the pharmacological action of a new, antiasthmatic, topically administered soft steroid, etiprednol dicloacetate (BNP-166). J Pharmacol Exp Ther. 2003;307(1):83-92. 2. Miklós A, et al. 28-day oral toxicity study with soft corticosteroid BNP-166 in rats and dogs, followed by a 14-day recovery period. Pharmazie. 2002;57(2):142-146. 3. Kurucz I, et al. Anti-inflammatory effect and soft properties of etiprednol dicloacetate (BNP-166), a new, anti-asthmatic steroid. Pharmazie. 2004;59(5):412-416. 4. Yang J, et al. Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor. Proc Natl Acad Sci U S A. 2018;115(26):6792-6797.

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Keywords

Etiprednol dicloacetate 199331-40-3 Others BNP 166 BNP166 BNP-166 inhibitor inhibit

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