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JNJ 10191584 maleate

Catalog No. T22879 CAS 869497-75-6

Synonyms: JNJ 10191584 maleate salt, VUF6002 maleate

JNJ 10191584 maleate (VUF6002 maleate) is an orally active and selective antagonist of H4 receptor (Ki = 26 nM). JNJ 10191584 maleate inhibits chemotaxis of eosinophils and mast cells (IC50 = 530 nM and 138 nM).

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JNJ 10191584 maleate, CAS 869497-75-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 84.00
2 mg	In stock	$ 126.00
5 mg	In stock	$ 183.00
10 mg	In stock	$ 226.00
25 mg	In stock	$ 497.00
50 mg	In stock	$ 723.00
100 mg	In stock	$ 987.00

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Purity: 99.82%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	JNJ 10191584 maleate (VUF6002 maleate) is an orally active and selective antagonist of H4 receptor (Ki = 26 nM). JNJ 10191584 maleate inhibits chemotaxis of eosinophils and mast cells (IC50 = 530 nM and 138 nM).
In vitro	JNJ 10191584 maleate shows 540-fold selectivity to H4 receptor(Ki = 14.1 μM)[2].
In vivo	In spared nerve injury mice, JNJ 10191584 maleate (10 μg/μL; intra locus coeruleus administration) abolishes VUF-induced anti-allodynic effect and prevents the anti-allodynic effect of VUF 8430. JNJ 10191584 maleate (6 μg/mouse; intrathecal administration) prevents VUF 8430-induced anti-allodynic effect[2].

Synonyms	JNJ 10191584 maleate salt, VUF6002 maleate
Molecular Weight	394.81
Formula	C17H19ClN4O5
CAS No.	869497-75-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 18mg/mL (45.6mM)

References and Literature

1. Sanna MD, et al. Histamine H4 receptor stimulation in the locus coeruleus attenuates neuropathic pain by promoting the coeruleospinal noradrenergic inhibitory pathway. Eur J Pharmacol. 2020 Feb 5;868:172859. 2. Venable JD, et al. Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonists. J Med Chem. 2005 Dec 29;48(26):8289-98.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Membrane Protein-targeted Compound Library GPCR Compound Library Neuronal Signaling Compound Library Bioactive Compounds Library Max Bioactive Compound Library ReFRAME Related Library Neurotransmitter Receptor Compound Library

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Keywords

JNJ 10191584 maleate 869497-75-6 GPCR/G Protein Immunology/Inflammation Neuroscience Histamine Receptor VUF6002 Maleate JNJ 10191584 Maleate JNJ 10191584 maleate salt VUF-6002 Maleate JNJ-10191584 Maleate VUF6002 maleate VUF 6002 Maleate JNJ10191584 Maleate inhibitor inhibit

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