dual — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T63536	Dual FAAH/sEH-IN-1		FAAH , Epoxide Hydrolase
	Dual FAAH/sEH-IN-1 is a dual inhibitor of sEH (soluble epoxide hydrolase) (IC50: 9.6 nM) and FAAH (fatty acid amide hydrolase) (IC50: 7 nM) with high affinity and anti-inflammatory activity.		FAAH , Epoxide Hydrolase
T2381	Abemaciclib	CDK4/6 dual inhibitor,LY2835219	CDK
	Abemaciclib (LY2835219) is a dual inhibitor of CDK4/6 (IC50=2/10 nM) with selectivity and specificity. Abemaciclib has antitumor activity and is used to treat advanced or metastatic breast cancer.		CDK
T1811	WH-4-023	KIN112,KIN001-112,Dual LCK/SRC inhibitor	Src
	WH-4-023 (Dual LCK/SRC inhibitor) is a potent and orally active Lck/Src inhibitor. It also potently inhibits SIK.		Src
T5093	Pim1/AKK1-IN-1	LKB1/AAK1 dual inhibitor,MDK-2275	Pim , Hippo pathway
	Pim1/AKK1-IN-1 (LKB1/AAK1 dual inhibitor) is a potent multi-kinase inhibitor with Kd values of 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1 respectively, and also inhibits MPSK1 and TNIK.		Pim , Hippo pathway
T82524	Dual photoCORM 1
	Dual photoCORM 1 (compound 5), a metal-free, photoactive, dual carbon monoxide releasing molecule (CORM), demonstrates efficient cellular uptake and enables real-time tracking of CO release via a colorimetric change in B...
T74991	Dual AChE-MAO B-IN-3
	Dual AChE-MAO B-IN-3 (Compound C10) is a potent inhibitor of both AChE and MAO-B, exhibiting IC50 values of 0.58 μM and 0.41 μM, respectively. This dual-binding inhibitor targets the catalytic anionic site and peripheral...
T62172	Dual AChE-MAO B-IN-1
	Dual AChE-MAO B-IN-1 (compound 15) is a safe, metabolically stable neuroprotective agent.Dual AChE-MAO B-IN-1 is a potent, orally active CNS-permeable inhibitor of human AChE (IC50=550 nM) and MAO-B (IC50=8.2 nM), and ha...
T62152	Dual AChE-MAO B-IN-2
	Dual AChE-MAO B-IN-2 is a potent, dual inhibitor of AChE (IC50: 0.12 μM) and MAO B (IC50: 0.01 μM).Dual AChE-MAO B-IN-2 has potential for Alzheimer's disease studies.
T2431	ID-8	ID8	DYRK
	ID-8, a DYRK inhibitor, sustains embryonic stem cell self-renewal in long-term culture.		DYRK
T75150	GIP/GLP-1 dual receptor agonist-1
	GIP/GLP-1 dual receptor agonist-1 (compound 4), a receptor agonist for both GIP and GLP-1, shows potential for the research of metabolic disorders and fatty liver diseases, such as nonalcoholic steatohepatitis (NASH) and...
T6257	AZ191		DYRK
	AZ191（IC50 of 17 nM） is an effective and specific DYRK1B inhibitor. The specificity of AZ191 for DYRK1B is about 5- and 110-fold greater over DYRK1A and DYRK2, respectively.		DYRK
T15422	GSK-626616		DYRK
	GSK-626616 is a potent and orally bioavailable DYRK3 inhibitor (IC50: 0.7 nM). It inhibits other members of the DYRK family with similar potency. GSK-626616 is a potential therapy for the treatment of anemia.		DYRK
TQ0111	LDN-192960		DYRK , Haspin Kinase
	LDN-192960 is a potent inhibitor of Haspin and DYRK2 (IC50s: 10 nM and 48 nM).		DYRK , Haspin Kinase
T1711	Harmine	Telepathine	MAO , 5-HT Receptor , DYRK
	Harmine (Telepathine) is an alkaloid isolated from seeds of Peganum harmala.		MAO , 5-HT Receptor , DYRK
T11447	GNF4877		GSK-3 , DYRK
	GNF4877 is a potent DYRK1A and GSK3β inhibitor (IC50s: 6 nM and 16 nM). It leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and increased β-cell proliferation cells.		GSK-3 , DYRK
T40187	GNF2133		DYRK
	GNF2133 is an effective and selective inhibitor of DYRK1A with IC50s of 6.2 nM. GNF2133 can be used in studies about type 1 diabetes.		DYRK
T2811	Harmine hydrochloride	telepathine hydrochloride	5-HT Receptor , DYRK , GluR
	Harmine hydrochloride (telepathine hydrochloride) is extracted from Peganum Harmala Genus.		5-HT Receptor , DYRK , GluR
T7323	BCI-215		Phosphatase
	BCI-215 causes selective cancer cell cytotoxicity in part through non-redox-mediated activation of MAPK signaling		Phosphatase
T14980	CLK-IN-T3		DYRK , CDK
	CLK-IN-T3 is an inhibitor of CLK1, CLK2, and CLK3 with IC50s of 0.67, 15, and 110 nM. CLK-IN-T3 exhibits anti-cancer activity.		DYRK , CDK
T14364	AZ-Dyrk1B-33	3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine	DYRK
	AZ-Dyrk1B-33 (3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine) is a potent and selective Dyrk1B kinase inhibitor with an IC50 of 7 nM.		DYRK