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GSK-626616

Catalog No. T15422 CAS 1025821-33-3

GSK-626616 is a potent and orally bioavailable DYRK3 inhibitor (IC50: 0.7 nM). It inhibits other members of the DYRK family with similar potency. GSK-626616 is a potential therapy for the treatment of anemia.

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GSK-626616, CAS 1025821-33-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 44.00
5 mg	In stock	$ 97.00
10 mg	In stock	$ 155.00
25 mg	In stock	$ 296.00
50 mg	In stock	$ 547.00
100 mg	In stock	$ 789.00
1 mL * 10 mM (in DMSO)	In stock	$ 97.00

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Purity: 99.48%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	GSK-626616 is a potent and orally bioavailable DYRK3 inhibitor (IC50: 0.7 nM). It inhibits other members of the DYRK family with similar potency. GSK-626616 is a potential therapy for the treatment of anemia.
Targets&IC50	β-glucuronidase:0.7 nM
In vitro	GSK-626616 (serum-deprived HeLa cells) reduces EGF-induced phosphorylation of PRAS40 at Thr246. GSK-626616 enhances the binding of PRAS40 to mTORC1[2]. GSK-626616 abolishes the phosphorylation of S6K1 at Thr389 in nonstimulated HeLa cells. GSK-626616 reduces the phosphorylation of S6K1 at Thr389 in EGF- and insulin-stimulated HeLa cells, showing that mTORC1 activity is impaired[2].

Molecular Weight	401.27
Formula	C18H10Cl2N4OS
CAS No.	1025821-33-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 49 mg/mL (122.11 mM), Sonification is recommended.

References and Literature

1. Connie L. Erickson-Miller, et al. GSK626616: A DYRK3 Inhibitor as a Potential New Therapy for the Treatment of Anemia. Blood 2007 110:510;

Related compound libraries

This product is contained In the following compound libraries：

Tyrosine Kinase Inhibitor Library Drug Repurposing Compound Library Anti-Cancer Drug Library Inhibitor Library Anti-Cancer Clinical Compound Library Hematonosis Compound Library Cell Cycle Compound Library Bioactive Compounds Library Max Anti-Cancer Compound Library Clinical Compound Library

Related Products

Related compounds with same targets

ML167 HTH-01-091 ID-8 Harmine hydrochloride ML 315 CLK1-IN-3 INDY GNF2133

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

GSK-626616 1025821-33-3 Cell Cycle/Checkpoint Tyrosine Kinase/Adaptors DYRK GSK 626616 Inhibitor Dual specificity tyrosine regulated kinase GSK626616 inhibit Dual specificity tyrosine phosphorylation regulated kinase inhibitor

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