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LDN-192960

Catalog No. TQ0111 CAS 184582-62-5

LDN-192960 is a potent inhibitor of Haspin and DYRK2 (IC50s: 10 nM and 48 nM).

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LDN-192960, CAS 184582-62-5

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	LDN-192960 is a potent inhibitor of Haspin and DYRK2 (IC50s: 10 nM and 48 nM).
Targets&IC50	Haspin:10 nM, DYRK2:48 nM

Molecular Weight	328.43
Formula	C18H20N2O2S
CAS No.	184582-62-5

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 30 mg/mL (91.34 mM)

H2O: 10 mg/mL (30.45 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Cuny GD, et al. Structure-activity relationship study of acridine analogs as haspin and DYRK2 kinase inhibitors. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3491-4.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Inhibitor Library Cell Cycle Compound Library Kinase Inhibitor Library Bioactive Compound Library Tyrosine Kinase Inhibitor Library

Related Products

Related compounds with same targets

LDN-192960 AZ1495

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

LDN-192960 184582-62-5 蛋白酪氨酸激酶细胞周期 Haspin Kinase DYRK Dual specificity tyrosine regulated kinase Inhibitor Dual specificity tyrosine phosphorylation regulated kinase LDN 192960 LDN192960 inhibit inhibitor

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