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LDN-192960

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Purity:99.32%

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COA HPLC HNMR

LDN-192960

Catalog No. TQ0111Cas No. 184582-62-5

LDN-192960 is a potent inhibitor of Haspin and DYRK2 (IC50s: 10 nM and 48 nM).

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$133	In Stock
5 mg	$163	In Stock
10 mg	$263	In Stock
25 mg	$528	In Stock
50 mg	$769	In Stock
100 mg	$1,080	In Stock
500 mg	$2,160	In Stock
1 mL x 10 mM (in DMSO)	$178	In Stock

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Product Introduction

Bioactivity

Description

LDN-192960 is a potent inhibitor of Haspin and DYRK2 (IC50s: 10 nM and 48 nM).

Chemical Properties

Molecular Weight	328.43
Formula	C18H20N2O2S
Cas No.	184582-62-5

Storage & Solubility Information

Storage

|Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 5.5 mg/mL (16.75 mM), Sonication is recommended.

MeOH: 1 mg/mL (3.04 mM)

Solution Preparation Table

DMSO/MeOH

	1mg	5mg	10mg	50mg
1 mM	3.0448 mL	15.2239 mL	30.4479 mL	152.2394 mL

DMSO

	1mg	5mg	10mg	50mg
5 mM	0.6090 mL	3.0448 mL	6.0896 mL	30.4479 mL
10 mM	0.3045 mL	1.5224 mL	3.0448 mL	15.2239 mL
20 mM	0.1522 mL	0.7612 mL	1.5224 mL	7.6120 mL
50 mM	0.0609 mL	0.3045 mL	0.6090 mL	3.0448 mL
100 mM	0.0304 mL	0.1522 mL	0.3045 mL	1.5224 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc