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Search Results for " chromatin "

20

Compounds

Cat No. Product Name Synonyms Targets
T7378 BRD9539 Histone Methyltransferase
BRD9539 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2), also known as G9a, with an IC50 value of 6.3 μM
T2354 UNC 0631 UNC0631 Histone Methyltransferase
UNC 0631 is a effectvie histone methyltransferase G9a inhibitor (IC50=4 nM).
T1923 BRD4770 Histone Methyltransferase
BRD4770 is a histone methyltransferase G9a inhibitor and induces cell senescence.
T17203 UNC0224 Histone Methyltransferase
UNC0224 is a selective inhibitor of G9a with a Ki of 2.6 nM and IC50 of 15 nM. UNC0224 also potently inhibits GLP with assay-dependent IC50 values of 20-58 nM.
TQ0232 UNC0646 UNC 0646 Histone Methyltransferase
UNC0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP (IC50s: 6 nM/15 nM for G9a/GLP). UNC0646(UNC 0646) potently blocks G9a/GLP methyltransferase activity in cells ...
T5443 JQ-1 (carboxylic acid) JQ-1 carboxylic acid Epigenetic Reader Domain
JQ-1 (carboxylic acid) is a cell-permeable BRD4 inhibitor with IC50s of 77 nM for BRD4(1) and 33 nM for BRD4(2)
T15212 Emamectin Benzoate MK-244 Apoptosis , Reactive Oxygen Species , GABA Receptor , Parasite
Emamectin Benzoate (MK-244), by binding gamma-aminobutyric acid (GABA) receptor and glutamate-gated chloride channels disrupting nerve signals within arthropods, acts as a chloride channel activator.
T8955 PCNA-I1 Others
PCNA-I1 is an inhibitor targeting PCNA chromatin association in prostate cancer.
T15784 LP99 Epigenetic Reader Domain
LP99 is an epigenetic probe. LP99 disrupts the binding of BRD7 and BRD9 to chromatin in cells. LP99 is an effective and selective inhibitor of the BRD7 and BRD9 bromodomains (Kd: 99 nM against BRD9).
T13974 ZL0580 Epigenetic Reader Domain , HIV Protease
ZL0580 induces HIV suppression by inhibiting Tat transactivation and transcription elongation as well as by inducing repressive chromatin structure at the HIV promoter.
T3661 Citarinostat ACY241,HDAC-IN-2 HDAC
ACY-241, also known as Citarinostat (ACY241), is a potent, selective and orally available histone deacetylase (HDAC) inhibitor, with potential antineoplastic activity. Upon oral administration, ACY-241 inhibits the activ...
T10616 BRM/BRG1 ATP Inhibitor-1 Epigenetic Reader Domain
BRM/BRG1 ATP Inhibitor-1 is an allosteric dual Brahma homolog (BRM)/SWI/SNF related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 (SMARCA2) and BRG1/SMARCA4 ATPase activity inhibitor (IC50...
T6270 Trichostatin A TSA HDAC
Trichostatin A (TSA) is a natural derivative of diene isohydroxamic acids. Trichostatin A is a histone deacetylase inhibitor (IC50=1.8 nM) that is reversible and specific. Trichostatin A leads to the hyperacetylation of ...
T40834 5-Hydroxymethyl-2'-deoxycytidine 5hmdC PARP
5-Hydroxymethyl-2'-deoxycytidine is an oxidized derivative of 5-methyl-2'-deoxycytidine (5-mdC) in DNA, causing DNA damage reactions, chromosomal aberrations, replication fork damage, and loss of cell viability.5-Hydroxy...
T3712 Mivebresib ABBV-075 Apoptosis , Epigenetic Reader Domain
Mivebresib (ABBV-075), also known as ABBV-075, is a potent BET inhibitor (bromodomain (BRD)-containing protein) with potential antineoplastic activity. Upon administration, the bromodomain inhibitor ABBV-075 binds to the...
T6S2391 L-Chicoric Acid (-)-Chicoric acid,trans-Caffeoyltartaric acid,Chicoric acid,dicaffeoyltartaric acid Others , HIV Protease
L-Chicoric Acid (trans-Caffeoyltartaric acid) has been shown to inhibit hyaluronidase and HIV-1 integrase, and to possess phagoeytosis stimulatory activity in vitro and in vivo and antiviral acitivy. L-Chicoric acid may ...
T4126 CBL0137 Curaxin 137,CBLC137 NF-κB , p53
CBL0137 (Curaxin 137), a metabolically stable curaxin, activates p53 (EC50: 0.37 μM) and inhibits NF-κB (EC50: 0.47 μM). It functionally inactivates the facilitates chromatin transcription complex (FACT), driving the eff...
T27083 Crebinostat Epigenetic Reader Domain , Histone Acetyltransferase , HDAC
Crebinostat is a potent histone deacetylase (HDAC) inhibitor, inhibiting HDAC1, HDAC2, HDAC3, and HDAC6 with IC50s of 0.7 nM, 1.0 nM, 2.0 nM, and 9.3 nM, respectively.Crebinostat increases the density of synapsin-1 punct...
T22845 I-BET151 dihydrochloride I-BET 151 hydrochloride Others
I-BET 151 dihydrochloride is a BET bromodomain inhibitor that prevents BET from recruiting to chromatin.
T13342 WDR5-IN-4 WIN site inhibitor 1 Others
WIN site inhibitor 1 is a WIN site of chromatin-associated WD repeat-containing protein 5 (WDR5) inhibitor (Kd: 0.1 nM), with anti-cancer activity.
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