Powder: -20°C for 3 years | In solvent: -80°C for 1 year
UNC0224 is a selective inhibitor of G9a with a Ki of 2.6 nM and IC50 of 15 nM. UNC0224 also potently inhibits GLP with assay-dependent IC50 values of 20-58 nM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 47.00 | |
2 mg | In stock | $ 67.00 | |
5 mg | In stock | $ 98.00 | |
10 mg | In stock | $ 162.00 | |
25 mg | In stock | $ 373.00 | |
50 mg | In stock | $ 588.00 | |
100 mg | In stock | $ 838.00 | |
500 mg | In stock | $ 1,720.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 109.00 |
Description | UNC0224 is a selective inhibitor of G9a with a Ki of 2.6 nM and IC50 of 15 nM. UNC0224 also potently inhibits GLP with assay-dependent IC50 values of 20-58 nM. |
Targets&IC50 | G9a:15 nM, G9a:2.6 nM (ki), G9a:23 nM (kd), GLP:20-58 nM |
In vitro | In G9a ECSD and CLOT assays, the IC50 values are 43 nM and 57 nM for UNC0224, respectively. In GLP ECSD and CLOT assays, the IC50 values are 50 nM and 58 nM for UNC0224, respectively. UNC0224 is inactive against SET7/9, SET8/PreSET7, PRMT3, and JMJD2E. In ITC experiments, the Kd of UNC0224 to the G9a protein is 23 nM[1]. |
Molecular Weight | 485.67 |
Formula | C26H43N7O2 |
CAS No. | 1197196-48-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 16 mg/mL (32.94 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
UNC0224 1197196-48-7 Chromatin/Epigenetic Histone Methyltransferase K373 G9a PKMT lysine UNC 0224 SAR stabilized p53 inhibit quinazoline H3K9 GLP Inhibitor UNC-0224 chromatin inhibitor