cholinergic — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T3026	(-)-Huperzine A	HupA,Huperzine A	Apoptosis , AChR , AChE , iGluR
	(-)-Huperzine A (HupA) , an active Lycopodium alkaloid extracted from the traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the tr...		Apoptosis , AChR , AChE , iGluR
T11861	LM11A-31 dihydrochloride		Others
	LM11A-31 dihydrochloride is a water-soluble, non-peptide with high blood-brain barrier permeability.LM11A-31 dihydrochloride, a p75NTR (neurotrophin receptor p75) Ligand, is a potent proNGF (nerve growth factor) antagoni...		Others
T0229	Rivastigmine	SDZ-ENA 713,S-Rivastigmine,Exelon	AChE
	Rivastigmine (Exelon) is a Cholinesterase Inhibitor, used for therapy of Alzheimer disease.		AChE
T1628	Rivastigmine tartrate	SDZ-ENA 713,ENA 713	AChR , AChE
	Rivastigmine tartrate (SDZ-ENA 713) is a carbamate-derived reversible CHOLINESTERASE INHIBITOR that is selective for the CENTRAL NERVOUS SYSTEM and is used for the treatment of DEMENTIA in ALZHEIMER DISEASE and PARKINSON...		AChR , AChE
T0236	Azatadine dimaleate	SCH10649,Azatadine Maleate	5-HT Receptor , AChR , Histamine Receptor
	Azatadine dimaleate (SCH10649) is an inhibitor for histamine（IC50=6.5 nM） and cholinergic（IC50=10 nM）.		5-HT Receptor , AChR , Histamine Receptor
T10914L	Cyclodrine	Cyclopent	AChR
	Cyclodrine (Cyclopent) is a cholinergic (muscarinic, nicotinic) (mAChR and nAChR) receptor antagonist.		AChR
T34114	Posatirelin	BRN 6006446,Posatirelinum,BRN-6006446,RGH-2202,BRN6006446	AChR
	Posatirelin (BRN6006446) is a synthetic peptide with modulatory activity and neurotrophic effects on monoaminergic and cholinergic systems for the study of vascular dementia.		AChR
T10914	Cyclodrine hydrochloride		AChR
	Cyclodrine hydrochloride is a dual cholinergic muscarinic receptor (mAChR) and nicotinic receptor (nAChR) antagonist that can be used in the study of neurologically related diseases.		AChR
T5655	MAChR-IN-1 hydrochloride		AChR
	mAChR-IN-1 hydrochloride is a potent muscarinic cholinergic receptor (mAChR) antagonist, with an IC50 of 17 Nm.		AChR
T26778	Besipirdine	HP 749 free base,P-867493,P867493,HP 749,HP749,P 867493	Sodium Channel , Adrenergic Receptor
	Besipirdine (HP 749 free base) is a non-receptor-dependent cholinomimetic compound with alpha-adrenergic and cardiovascular activities.Besipirdine inhibits voltage-dependent sodium-potassium channels and inhibits biogeni...		Sodium Channel , Adrenergic Receptor
T27404	GAT107	GAT 107,GAT-107	AChR
	GAT107 is a novel and potent α7 nicotinic cholinergic receptor modifier agonist and modulator with anti-inflammatory activity that reverses injury perception in a mouse model of neuropathic pain.		AChR
T6S0109	Sipeimine	Kashmirine,Imperialine	Others
	1. Sipeimine (Kashmirine) has antiasthmatic effect, on tracheal M receptor antagonist. 2. Sipeimine can make Kaba cholinergic induced contraction of tracheal strips of the dose-response curve to the right.		Others
T2571	Benactyzine hydrochloride	Neuroleptone,Tranquilline,Amitakon	AChR , AChE
	Benactyzine hydrochloride (Neuroleptone) is a centrally acting muscarinic antagonist. Benactyzine has been used in the treatment of depression and is used in research to investigate the role of cholinergic systems on beh...		AChR , AChE
T21439	Tacrine	CS 12602,Tacrinum,Tetrahydroaminocrine	AChR
	Tacrine (CS 12602) is an indirect cholinergic agonist and centrally acting anticholinesterase. It is approved for the treatment of Alzheimer's disease.		AChR
T3767	Polygalacic acid	Virgaureagenin G	MMP , AChR , AChE
	Polygalacic acid (Virgaureagenin G)(PA) significantly improves cholinergic system reactivity, as indicated by decreased acetylcholinesterase (AChE) activity, increases choline acetyltransferase (ChAT) activity, and eleva...		MMP , AChR , AChE
T0169	Nefiracetam	DM9384,DZL-221	GABA Receptor
	Nefiracetam (DM9384) are underway in Phase 2 trials. Nefiracetam, a GABAergic、 cholinergic、and monoaminergic neuronal system enhancer, is used for Ro 5-4864-induced convulsions.		GABA Receptor
T50047	1-(3,4-dihydroxyphenyl)-2-(dimethylamino)ethan-1-one hydrochloride		Others
	1-(3,4-dihydroxyphenyl)-2-(dimethylamino)ethan-1-one hydrochloride is a cholinergic agent that inhibits choline metabolism, which leads to increased levels of acetylcholine in the brain, which in turn enhances cognitive ...		Others
TN1236	3',4',7-Trihydroxyisoflavone		MAPK , JNK
	3',4',7-Trihydroxyisoflavone is a soy isoflavone soy glycoside derivative and Cot (Tpl2/MAP3K8) and MKK4 inhibitor with anticancer, antiangiogenic and free radical scavenging properties.3',4',7-Trihydroxyisoflavone enhan...		MAPK , JNK
T1221	Acetylcholine chloride	ACh chloride,Pilofrin	Calcium Channel , Endogenous Metabolite , AChR
	Acetylcholine Chloride is the chloride salt form of acetylcholine, a synthetic, quaternary amino alcohol with cholinergic properties. Acetylcholine chloride (Pilofrin) mimics the parasympathomimetic effect of the endogen...		Calcium Channel , Endogenous Metabolite , AChR
T6707	Tiotropium Bromide hydrate	BA-679 BR hydrate,BA 679BR	AChR
	Tiotropium Bromide hydrate (BA-679 BR hydrate) is a potent anticholinergic and bronchodilator, serving as a muscarinic receptor antagonist, specifically targeting mAChR. It is developed for treating chronic obstructive a...		AChR