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Posatirelin

Catalog No. T34114 CAS 78664-73-0

Synonyms: BRN 6006446, Posatirelinum, BRN-6006446, RGH-2202, BRN6006446

Posatirelin (BRN6006446) is a synthetic peptide with modulatory activity and neurotrophic effects on monoaminergic and cholinergic systems for the study of vascular dementia.

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Posatirelin, CAS 78664-73-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 130.00
5 mg	In stock	$ 320.00
10 mg	In stock	$ 480.00
25 mg	In stock	$ 786.00
50 mg	In stock	$ 1,080.00
100 mg	In stock	$ 1,480.00
500 mg	In stock	$ 2,960.00

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Purity: 98.22%

ee: 100%

Purity: 97.41%

Biological Description

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Description

Posatirelin (BRN6006446) is a synthetic peptide with modulatory activity and neurotrophic effects on monoaminergic and cholinergic systems for the study of vascular dementia.

In vivo

The pharmacokinetics and endocrine effects of a therapeutic dose (10 mg/day) of posatirelin were investigated in healthy elderly subjects. Posatirelin was given once daily by intramuscular injection for 7 days. Pharmacokinetic parameters were estimated using a model-independent approach. The plasma concentrations of free triiodothyronine (FT3), free thyroxine (FT4), and thyroid-stimulating hormone (TSH) and the circadian rhythms of prolactin and cortisol were considered as indicators variables of endocrine response to posatirelin administration. Posatirelin was well tolerated and no significant adverse effects were observed during the study. There were no significant changes in these parameters after multiple-dose administration (day 7). Posatirelin induced a progressive reduction in basal TSH levels and maximum response. There were no significant changes during treatment in the time at which basal levels of FT3 and FT4 occurred, and these levels remained within the normal range throughout the study. The circadian rhythms of cortisol and prolactin were not influenced by posatirelin treatment. The pharmacokinetics of posatirelin were not time-dependent, and the drug did not accumulate after multiple-dose administration. Short-term treatment with posatirelin did not induce clinically relevant endocrine consequences in healthy elderly subjects.[1]

Synonyms	BRN 6006446, Posatirelinum, BRN-6006446, RGH-2202, BRN6006446
Molecular Weight	352.43
Formula	C17H28N4O4
CAS No.	78664-73-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Jantas D, Jaworska-Feil L, Lipkowski AW, Lason W. Effects of TRH and its analogues on primary cortical neuronal cell damage induced by various excitotoxic, necrotic and apoptotic agents. Neuropeptides. 2009 Oct;43(5):371-85. doi: 10.1016/j.npep.2009.07.002. Epub 2009 Aug 8. PubMed PMID: 19666192. 2. Gasbarrini G, Stefanini G, Addolorato G, et al. Posatirelin for the treatment of degenerative and vascular dementia: results of explanatory and pragmatic efficacy analyses. Arch Gerontol Geriatr. 1998 Jan-Feb;26(1):33-47. PubMed PMID: 18653124. 3. Pantoni L. Treatment of vascular dementia: evidence from trials with non-cholinergic drugs. J Neurol Sci. 2004 Nov 15;226(1-2):67-70. Review. PubMed PMID: 15537523. 4. Sarkadi A, Kárpáti E. [TRH analogs at Gedeon Richter Ltd.: highlights of experimental and clinical efficacy of posatirelin]. Acta Pharm Hung. 2002;72(1):62-8. Hungarian. PubMed PMID: 12426788.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Bioactive Compounds Library Max Bioactive Compound Library

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Keywords

Posatirelin 78664-73-0 Neuroscience AChR BRN 6006446 Posatirelinum BRN-6006446 RGH-2202 RGH2202 RGH 2202 BRN6006446 inhibitor inhibit

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