caspase-3 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T6005	Z-DEVD-FMK	Caspase-3 Inhibitor	Caspase
	Z-DEVD-FMK (Caspase-3 Inhibitor) is a selective, irreversible Caspase-3 inhibitor, and also exhibits effective inhibition activity on caspase-6, caspase-7, caspase-8, and caspase-10.		Caspase
T21871	MMPSI	Caspase-3/7 Inhibitor I	Apoptosis , Caspase
	MMPSI (Caspase-3/7 Inhibitor I) is a novel, non-peptide small molecule caspase 3 and caspase 7 inhibitor that reduces ischemic injury in isolated rabbit heart or cardiomyocytes and inhibits apoptosis of H16c2 cells in a ...		Apoptosis , Caspase
T11696	Ivachtin	Caspase-3 Inhibitor VII	Caspase
	Ivachtin (Caspase-3 Inhibitor VII) is a nonpeptide, noncompetitive and reversibl caspase-3 inhibitor(IC50 = 23 nM) and is a modest inhibitor of the remaining caspases.		Caspase
T10384	Farudodstat	ASLAN003	Apoptosis , Dehydrogenase , DNA/RNA Synthesis
	Farudodstat (ASLAN003) is an orally active and potent inhibitor of DHODH (Human Dihydroorotate Dehydrogenase) with antitumor activity. It has the potential to be a first-in-class candidate in AML.		Apoptosis , Dehydrogenase , DNA/RNA Synthesis
T1724	SCR7 pyrazine	SCR7	Apoptosis , DNA/RNA Synthesis , CRISPR/Cas9
	SCR7 pyrazine (SCR7) enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency in vitro up to 19-fold. Inhibits nonhomologous end-joining (NHEJ).		Apoptosis , DNA/RNA Synthesis , CRISPR/Cas9
T2532	Tauroursodeoxycholate	Taurolite,Tauroursodeoxycholic Acid,UR 906,Ursodeoxycholyltaurine,TUDCA	Apoptosis , ERK , P450 , Caspase , Endogenous Metabolite
	Tauroursodeoxycholate (UR 906), also known as ursodoxicoltaurine, is a highly hydrophilic tertiary bile acid that is produced in humans at a low concentration. Tauroursodeoxycholate is the more hydrophilic form of ursode...		Apoptosis , ERK , P450 , Caspase , Endogenous Metabolite
T82774	Caspase-3 activator 3		Caspase
	Caspase-3 activator 3 (compound 2h) effectively induces apoptosis in HL-60 and K562 cells by substantially activating caspase-3, demonstrating antileukemic activity with IC50 values of 42.89 μM and 33.61 μM, respectively...		Caspase
T0300	Pargyline	Pargylamine,Paragyline	MAO , Monoamine Oxidase
	Pargyline (Pargylamine) is a monoamine oxidase inhibitor with antihypertensive properties.		MAO , Monoamine Oxidase
T63479	Caspase-3-IN-1
	Caspase-3-IN-1 is a potent inhibitor of Caspase-3 (IC50: 14.5 nM).
T72316	Caspase-3/7 activator 3
	Caspase-3/7 Activator 3 is a potent and tumor-selective compound that effectively activates Caspase-3/7, demonstrating significant anti-proliferative activity and a high capacity to induce apoptosis.
T6258	Zibotentan	ZD4054	Apoptosis , Endothelin Receptor
	Zibotentan (ZD4054) (ZD4054) is a specific Endothelin (ET)A antagonist with IC50 of 21 nM, exhibiting no activity at ETB. Phase 3.		Apoptosis , Endothelin Receptor
T82775	Caspase-3 activator 2		Caspase
	Caspase-3 Activator 2 (Compound 2f) is a caspase 3 activator with cytotoxic effects on HL-60 and K562 cells, exhibiting IC 50 values of 33.52 μM and 76.90 μM, respectively [1]. It facilitates apoptosis, rendering it usef...		Caspase
T79743	Caspase-3 activator 1		Pyroptosis
	Caspase-3 activator 1 (compound 4b), a Ru(III) metal complex, effectively inhibits gastric tumor growth and metastasis by mediating caspase-3 cleavage. This cleavage enables Caspase-3 to process gasdermin E (GSDME), whic...		Pyroptosis
T5104	BTSA1		Apoptosis , BCL
	BTSA1 is a BAX activator that binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis.		Apoptosis , BCL
T8478	SC-43		Apoptosis , Phosphatase , STAT
	SC-43 is a potent and orally active agonist of SHP-1 (PTPN6). SC-43 inhibits the phosphorylation of STAT3 and induces cell apoptosis, and with anti-fibrotic and anticancer effects.		Apoptosis , Phosphatase , STAT
T6993	Tauroursodeoxycholate sodium	Sodium tauroursodeoxycholate,Tauroursodeoxycholic acid sodium salt,TUDC,Sodium Tauroursodeoxycholate (TUDC)	Apoptosis , ERK , Caspase
	Tauroursodeoxycholate sodium (TUDC) is an endoplasmic reticulum (ER) stress inhibitor, used for the treatment of gallstones and liver cirrhosis.		Apoptosis , ERK , Caspase
T2A2481	Taurochenodeoxycholic Acid	Chenodeoxycholyltaurine,TCDCA,Chenyltaurine,Taurochenodeoxycholate,12-Deoxycholyltaurine	Apoptosis , TNF , Caspase , Endogenous Metabolite
	Taurochenodeoxycholic Acid (12-Deoxycholyltaurine) is one of the main bioactive substances of animals' bile acid.		Apoptosis , TNF , Caspase , Endogenous Metabolite
T1578	Pargyline hydrochloride	Pargylamine hydrochloride	MAO , Monoamine Oxidase
	Pargyline hydrochloride (Pargylamine hydrochloride) is an irreversible monoamine oxidase(MAO) inhibitor with antihypertensive properties.		MAO , Monoamine Oxidase
T21936	M50054		Caspase
	Apoptosis Inhibitor was a novel inhibitor of programmed cell death associate with caspase-3 inhibition.		Caspase
TN2215	Taurochenodeoxycholic acid sodium	Sodium taurochenodeoxycholate	Apoptosis , Endogenous Metabolite
	Taurochenodeoxycholic acid sodium (Sodium taurochenodeoxycholate) is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid sodium induces apoptosis and shows obvious anti-inflammatory and...		Apoptosis , Endogenous Metabolite