brucei — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T4S0590	Columbin		Phospholipase , COX , Parasite
	1. Columbin has anti-inflammatory activity. 2. Columbin has chemopreventive ability against human colon cancer. 3. Columbin inhibits PLA2 hydrolysis of ghost RBC in a dose-dependent fashion.		Phospholipase , COX , Parasite
T64320	ML251		Glucokinase , Parasite
	ML251 is a potent novel nanomolar inhibitor of T. brucei and T. cruzi phosphofructokinase[1]. ML251 inhibits T. brucei PFK (IC50=0.37 μM) and T. cruzi PFK (IC50=0.13 μM). ML251 can be used for the research of parasite[1]...		Glucokinase , Parasite
T27135	DDD85646	DDD 85646,DDD-85646	Parasite
	DDD85646 is an inhibitor of T. brucei N-myristoyltransferase with a Ki of 1.44 nM, an IC50 of 2 nM and an EC50 of 2 nM. The IC50 of hNMT is 4 nM.		Parasite
T3S0153	Xanthatin		Apoptosis , VEGFR , Lipoxygenase , Wnt/beta-catenin , Antibacterial
	1. Xanthatin has cytotoxic activity. 2. Xanthatin has antibacterial and antifungal activies against MRSA. 3. Xanthatin may have therapeutic potential against NSCLC. 4. Xanthatin can inhibit murine melanoma B16-F1 cell pr...
TN1128	Bruceine E		Others
	Bruceine E is isolated from B. javanica seeds with hypoglycemia effects. Bruceine E can be used for studies about acting as an insulin secretagogue.		Others
TWS2045	Bruceine D		Apoptosis , Antiviral , Gamma-secretase , Parasite
	1. Bruceine D from Brucea javanica, may have the potential to be used as a natural viricide, or a lead compound for new viricides. 2. Bruceine D inhibits the growth of three pancreatic cancer cell lines, i.e., PANC-1, SW...		Apoptosis , Antiviral , Gamma-secretase , Parasite
T2S2046	Bruceine A	Dihydrobrusatol,NSC31616	Antibiotic , Parasite
	Bruceine A (NSC-31616)(NSC-310616; Dihydrobrusatol) is a natural quassinoid compound extracted from the dried fruits of Brucea javanica (L.); are potential candidates for the treatment of canine babesiosis.		Antibiotic , Parasite
T5768	bruceine B		TNF , Parasite
	Bruceine B, a potent inhibitor of leukocyte-endothelial cell adhesion, may have anti-inflammatory activity, it can inhibit neutrophil adhesion to lipopolysaccharide-stimulated HUVEC and T cell adhesion to TNF-stimulated ...		TNF , Parasite
T75558	Bruceine J
	Bruceine J, a quassinoid naturally derived from the fruits of Br. javanica, exhibits anti-Babesial activity [1].
T125190	Bruceine C
	Bruceine C is a useful organic compound for research related to life sciences and the catalog number is T125190.
TN3797	Dehydrobruceine A		Antifection
	Dehydrobruceine A shows strong antitrypanosomal activities with IC(50) values in the range of 2.9-17.8nM.		Antifection
T75485	Dehydrobruceine B
	Dehydrobruceine B, a quassinoid isolated from Brucea javanica, demonstrates a synergistic effect with Cisplatin in inducing apoptosis through the mitochondrial pathway. It enhances the expression of apoptosis-inducing fa...
T3792	Ajugol	Leonuride	Parasite
	Ajugol (Leonuride) shows some trypanocidal potential against Trypanosoma brucei rhodesiense (IC50 values 29.3–73.0 ug/ml).		Parasite
T63059	CRK12-IN-1		Antibiotic
	CRK12-IN-1 is a potent CRK12 inhibitor.CRK12-IN-1 has insecticidal activity, with inhibitory effects on Trypanosoma brucei (T.b. brucei) and Trypanosoma congolense (T. congolense) with EC50s of 1.3 and 18 nM, respectivel...		Antibiotic
T10339	Antitrypanosomal agent 1		Parasite
	Antitrypanosomal agent 1 is a potent and selective trypanothione reductase (TR) inhibitor (IC50: 3.3 μM). Antitrypanosomal agent 1 inhibits glutathione reductase (IC50: 64.8 μM) and T. brucei (EC50: 1 μM).		Parasite
T10340	Antitrypanosomal agent 2		Parasite
	Antitrypanosomal agent 2 shows potent and specific antiparasite activities against Trypanosoma brucei.		Parasite
T23973	DDD100097	DDD 100097,DDD-100097	Others
	DDD100097 is a potent N-myristoyltransferase inhibitor with potential inhibitory effects on Trypanosoma brucei, which can be used to study neurological disorders.		Others
TN1030	N-p-trans-Coumaroyltyramine		AChE , Parasite
	N-p-trans-Coumaroyltyramine is a natural product, is an acetylcholinesterase (AChE) inhibitor with an an IC50 of 122 μM. N-p-trans-Coumaroyltyramine exhibits anti-trypanosomal activity with an IC50 of 13.3 μM for T. bruc...		AChE , Parasite
T77551	6'-hydroxydihydrocinchonidine		Antibiotic , Drug Metabolite
	6'-hydroxydihydrocinchonidine is a metabolite of quinine, with antimicrobial and antitumor activity, and inhibitory effect on Trypanosoma brucei and Streptococcus pneumoniae.		Antibiotic , Drug Metabolite
T77645	JC-229		TRP/TRPV Channel
	JC-229 is a potent and selective TbRPA1 inhibitor that can inhibit RPA1 in Trypanosoma brucei. JC-229 can be used to study human African Trypanosomiasis (HAT).		TRP/TRPV Channel