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Bruceine A

Catalog No. T2S2046 CAS 25514-31-2

Synonyms: Dihydrobrusatol, NSC31616

Bruceine A (NSC-31616)(NSC-310616; Dihydrobrusatol) is a natural quassinoid compound extracted from the dried fruits of Brucea javanica (L.); are potential candidates for the treatment of canine babesiosis.

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Bruceine A, CAS 25514-31-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 51.00
5 mg	In stock	$ 122.00
10 mg	In stock	$ 172.00
25 mg	In stock	$ 297.00
50 mg	In stock	$ 458.00
100 mg	In stock	$ 673.00
1 mL * 10 mM (in DMSO)	In stock	$ 138.00

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Purity: 99.59%

Purity: 99.45%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Bruceine A (NSC-31616)(NSC-310616; Dihydrobrusatol) is a natural quassinoid compound extracted from the dried fruits of Brucea javanica (L.); are potential candidates for the treatment of canine babesiosis.
In vitro	Bruceine A inhibited the in vitro growth of Babesia gibsoni in canine erythrocytes at lower concentration compared with the standard antibabesial drug diminazene aceturate and killed the parasites within 24 hr at a concentration of 25 nM.
In vivo	Oral administration of bruceine A at a dosage of 6.4 mg/kg/day for 5 days resulted in no clinical findings in a dog with normal ranges of hematological and biochemical values in the blood. Three dogs were infected with B. gibsoni and two of them were treated with bruceine A at a dosage of 6.4 mg/kg/day for 6 days from day 5 post-infection.
Source	Natural Products > Simaroubaceae > Brucea

Synonyms	Dihydrobrusatol, NSC31616
Molecular Weight	522.54
Formula	C26H34O11
CAS No.	25514-31-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 12 mg/mL (22.96 mM ), Heating is recommended.

References and Literature

1. Nakao R, et al. Evaluation of efficacy of bruceine A, a natural quassinoid compound extracted from a medicinal plant, Brucea javanica, for canine babesiosis. J Vet Med Sci. 2009 Jan;71(1):33-41.

Related compound libraries

This product is contained In the following compound libraries：

Traditional Chinese Medicine Monomer Library Anti-Parasitic Compound Library Antiparasitic Natural Product Library Covalent Inhibitor Library Antibiotics Library Anti-infective Natural Product Library Covalent Natural Product Library NO PAINS Compound Library Selected Plant-Sourced Compound Library Natural Product Library for HTS

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Keywords

Bruceine A 25514-31-2 Microbiology/Virology Antibiotic Parasite NSC 310616 NSC-310616 NSC 31616 inhibit Dihydrobrusatol Inhibitor NSC-31616 NSC31616 NSC310616 inhibitor

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