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N-p-trans-Coumaroyltyramine

Catalog No. TN1030 CAS 36417-86-4

N-p-trans-Coumaroyltyramine is a natural product, is an acetylcholinesterase (AChE) inhibitor with an an IC50 of 122 μM. N-p-trans-Coumaroyltyramine exhibits anti-trypanosomal activity with an IC50 of 13.3 μM for T. brucei rhodesiense.

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N-p-trans-Coumaroyltyramine, CAS 36417-86-4

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	N-p-trans-Coumaroyltyramine is a natural product, is an acetylcholinesterase (AChE) inhibitor with an an IC50 of 122 μM. N-p-trans-Coumaroyltyramine exhibits anti-trypanosomal activity with an IC50 of 13.3 μM for T. brucei rhodesiense.
Targets&IC50	AChE:122 μM
In vitro	The methanolic extract of the twigs of Celtis chinensis was found to show inhibitory activity on acetylcholinesterase (AChE), an enzyme that plays a role in the metabolic hydrolysis of ACh. Bioassay-guided fractionation of the methanolic extract resulted in the isolation of N-p-trans-Coumaroyltyramine, as an inhibitor on AChE[1]

Molecular Weight	283.33
Formula	C17H17NO3
CAS No.	36417-86-4

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 27.5 mg/mL (97.06 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Inhibitory effect of trans-N-p-coumaroyl tryamine from the twigs of Celtis chinensis on the acetylcholinesterase.Arch. Pharm. Res.,2003, 26(9):735-8.

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Keywords

N-p-trans-Coumaroyltyramine 36417-86-4 Microbiology/Virology Neuroscience Parasite AChE Inhibitor Cholinesterase (ChE) inhibit N p trans Coumaroyltyramine NptransCoumaroyltyramine inhibitor

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