20
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T2086 | ELN-441958 | ELN 441958 | Bradykinin Receptor |
ELN-441958 is a potent, neutral antagonist of B1 receptor, inhibits the binding of the B1 agonist ligand [3H]DAKD to IMR-90 cells with Ki of 0.26 nM. ELN-441958(ELN 441958) is highly selective for B1 over B2 receptors. | |||
T1770 | GNE-9605 | LRRK2 | |
GNE-9605 is a highly effective, specifical, and brain-penetrant LRRK2 inhibitor (IC50: 19 nM). | |||
T13099 | TC ASK 10 | ASK , MAPK | |
TC ASK 10 is a potent, selective and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1)(IC50 of 14 nM). | |||
T10606 | BRD0705 | GSK-3 | |
BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor (IC50: 66 nM; Kd: 4.8 μM). BRD0705 displays increased selectivity for GSK3α (8-fold) versus GSK3β (IC50: 515 nM). | |||
TQ0239 | PF-06291874 | Glucagon receptor antagonists-4 | Glucagon Receptor |
PF-06291874 (Glucagon receptor antagonists-4) (Glucagon receptor antagonists-4) is a highly effective and orally active antagonist of the glucagon receptor. | |||
T24493 | Monoelaidin | ||
Monoelaidin is a poorly water-soluble drug enhancer of solubility and oral bioavailability. | |||
T8160 | EGCG Octaacetate | Others , Antibacterial | |
EGCG Octaacetate, a prodrug of EGCG, is utilized to enhance the stability and bioavailability of EGCG in vivo. It has high efficacy, bioavailability, anti-oxidation, and anti-angiogenesis capacities. | |||
T69757 | PDDC inhibitor | ||
PDDC is the first nSMase2 inhibitor that possesses both favorable pharmacodynamics and pharmacokinetic (PK) parameters, including substantial oral bioavailability, brain penetration, and significant inhibition of exosome... | |||
T19609 | HP-β-CD | Hydroxypropyl-β-cyclodextrin,Hydroxypropyl betadex | Others |
HP-β-CD (HP-β-CD) is a widely used drug delivery vehicle to improve stability and bioavailability. | |||
T9173 | HM-30181 mesylate monohydrate | P-gp | |
HM-30181 mesylate monohydrate is an oral P-glycoprotein (P-gp) inhibitor, used to enhance the oral bioavailability of P-gp substrate drugs. | |||
T15409 | GNF179 | Parasite | |
GNF179 is an optimized 8,8-dimethyl IP analog. It exhibited the potency(4.8 nM against the multidrug resistant strain W2) in vitro metabolic stability and in vivo oral bioavailability. | |||
T8850 | Sbp-7455 | Autophagy | |
SBP-7455 potently inhibited ULK1/2 enzymatic activity in vitro and in cells, reduced the viability of TNBC cells and had oral bioavailability in mice. | |||
T7614 | Eniluracil | GW776C85,5-Ethynyluracil | Others |
Eniluracil (GW776C85) is an orally activedihydropyrimidine dehydrogenase (DPD) inhibitor,increases the oral bioavailability of 5-FU to 100%, facilitating uniform absorption and predictable toxicity. | |||
TQ0039 | (±)-Zanubrutinib | (±)-BGB-3111 | BTK |
(±)-Zanubrutinib ((±)-BGB-3111) is a potent and orally available Bruton's tyrosine kinase (Btk) inhibitor that demonstrates superior oral bioavailability, achieving higher exposure and more complete target inhibi. | |||
T7897 | PK150 | Others , Antibacterial | |
PK150 shows oral bioavailability and antibacterial activity against several pathogenic strains at submicromolar concentrations. | |||
T26863 | BMS-929075 | BMS 929075,BMS929075 | HCV Protease |
BMS-929075 is an orally active HCV NS5B replicase (HCV NS5B replicase) palm site variant inhibitor with potency, high oral bioavailability and pharmacokinetic parameters.BMS-929075 shows cytotoxicity. | |||
T9692 | Paltusotine | Somatostatin | |
Paltusotine is a nonpeptide, small molecule somatostatin type 2 (SST2) receptor agonist with high oral bioavailability. Paltusotine maintains GH and IGF-1 levels in acromegaly patients | |||
T16143 | MRTX-1257 | Ras | |
MRTX-1257 is a selective, irreversible, and covalent inhibitor of KRAS G12C. It has an IC50 of 900 pM for KRAS dependent ERK phosphorylation in H358 cells. MRTX1257 demonstrated 31% bioavailability in the mouse, with fre... | |||
T3312 | AM-2394 | AM2394 | Glucokinase |
AM-2394 is an effective and specific Glucokinase agonist (GKA, EC50: 60 nM), which catalyzes the phosphorylation of glucose to glucose-6-phosphate. AM-2394(AM2394) increases the affinity of GK for glucose by approximatel... | |||
T24480 | MK-8325 | MK 8325,MK8325 | HCV Protease |
MK-8325 is a potent and orally available HCV NS5A inhibitor with replicative activity against a wide range of genotypes.MK-8325 has demonstrated bioavailability in in vitro and in vivo assays and has a favorable overall ... |