yap-tead — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TP2160L1	YAP-TEAD-IN-1 acetate	YAP-TEAD-IN-1 acetate (1659305-78-8 Free base)	YAP
	YAP-TEAD-IN-1 acetate is an effective and competitive inhibitor of YAP–TEAD interaction with an IC50 of 25 nM.		YAP
TP2160	YAP-TEAD-IN-1		Others
	YAP-TEAD-IN-1 is a competitive inhibitor of YAP–TEAD interaction (IC50: 25 nM). It shows a higher binding affinity to TEAD1 (Kd: 15 nM) than YAP (50-171) (Kd: 40 nM).		Others
TP2160L	YAP-TEAD-IN-1 TFA		Others
	YAP-TEAD-IN-1 TFA is a competitive inhibitor of YAP–TEAD interaction (IC50: 25 nM). It shows a higher binding affinity to TEAD1 (Kd: 15 nM) than YAP (50-171) (Kd: 40 nM).		Others
T8421	TED-347		YAP
	TED-347 is an irreversible and covalent inhibitor of TEAD4-Yap1 protein-protein interaction(EC50 of 5.9 μM), and inhibits glioblastoma cell viability.		YAP
T9954	K-975		Others
	K-975 is a highly selective, orally active TEAD inhibitor, effectively inhibiting protein-protein interactions between TEAD and YAP1/TAZ.		Others
T72888	YAP-TEAD-IN-2		YAP
	YAP-TEAD-IN-2 (compound 6) serves as a potent inhibitor of the YAP-TEAD protein-protein interaction (PPI), demonstrating an inhibitory concentration 50 (IC50) value of 2.7 nM [1].		YAP
T77725	YAP-TEAD-IN-3	IAG933	YAP
	YAP-TEAD-IN-3 is an inhibitor of YAP/TAZ-TEAD interactions with an IC50 of 9 nM for Avi-human TEAD (4217-434). YAP-TEAD-IN-3 inhibits YAP reporter gene expression (IC50 = 0.048 μM) and NCI-H2052 cell proliferation (IC50 ...		YAP
T22372	MYF-01-37	1-[3-Methyl-3-[3-(trifluoromethyl)anilino]pyrrolidin-1-yl]prop-2-en-1-one	Others , YAP
	MYF-01-37 (1-[3-Methyl-3-[3-(trifluoromethyl)anilino]pyrrolidin-1-yl]prop-2-en-1-one) is a novel covalent TEAD inhibitor.		Others , YAP
T3112	Verteporfin	BPD-MA,CL 318952	Apoptosis , YAP , VDA , Autophagy
	Verteporfin (BPD-MA) is a YAP inhibitor that inhibits YAP-TEAD interactions. Verteporfin is also a photosensitizer used in photodynamic therapy. Verteporfin also induces apoptosis and inhibits autophagy.		Apoptosis , YAP , VDA , Autophagy
T60218	YAP/TAZ inhibitor-2		YAP
	YAP/TAZ inhibitor-2 is a potent and orally active TEAD-YAP/TAZ inhibitor with an EC 50 value of 3 nM. YAP/TAZ inhibitor-2 shows anti-proliferative and antitumor activity [1].		YAP
T60148	MSC-4106		YAP
	MSC-4106, an orally active and potent YAP/TAZ-TEAD inhibitor, disrupts TEAD1 and TEAD3 auto-palmitoylation and demonstrates significant efficacy in the NCI-H226 tumor xenograft model [1].		YAP
T62077	VT103	VT-103,VT 103	YAP
	VT103 is an orally active and selective inhibitor of TEAD1 protein palmitoylation and is an analog of VT101. VT103 has potential antitumor activity by inhibiting YAP/TAZ-TEAD-promoted gene transcriptionment, blocking TEA...		YAP
T69760	TT-10	TAZ-K	YAP
	TT-10 (TAZ-K), an activator of YES-associated protein (YAP)-transcriptional enhancer factor domain (TEAD) activity, has potential application in heart disease research, specifically for conditions characterized by loss o...		YAP
T1679	Thiostrepton	Thiactin,Bryamycin,Alaninamide	DNA/RNA Synthesis , Antibacterial , Antibiotic
	Thiostrepton (Alaninamide) is a one of the CYCLIC PEPTIDES from Streptomyces that is active against gram-positive bacteria. In veterinary medicine, it has been used in mastitis caused by gram-negative organisms and in de...		DNA/RNA Synthesis , Antibacterial , Antibiotic
T81056	SWTX-143		YAP
	SWTX-143, a novel covalent inhibitor, specifically and irreversibly binds to the palmitoylation pocket of all four TEAD isoforms, inhibiting the transcriptional activity of the YAP/TAZ-TEAD complex and demonstrating anti...		YAP
T83951	TM2 TEAD inhibitor
	TM2 TEAD inhibitor, a robust and reversible inhibitor of the TEA domain transcription factor, presents dual inhibitory concentrations (IC50) of 38 nM for TEAD4 auto-palmitoylation and 156 nM for TEAD2 palmitoylation. It ...
T76005	Super-TDU (1-31)
	Super-TDU (1-31), a peptide fragment of Super-TDU, acts as an inhibitor of the YAP-TEAD complex. Demonstrating potent anti-tumor activity, it effectively suppresses tumor growth in a gastric cancer mouse model [1] [2].
T76005L	Super-TDU (1-31) (TFA)
	Super-TDU (1-31) TFA, a peptide fragment of Super-TDU, acts as an inhibitor of the YAP-TEAD complex. Demonstrating potent anti-tumor activity, it effectively suppresses tumor growth in a gastric cancer mouse model [1] [2...
T78558	GNE-7883

T76004	Super-TDU TFA
	Super-TDU TFA, a specialized YAP antagonist, specifically inhibits the interaction between YAP and TEADs. This compound demonstrates tumor growth suppression in a gastric cancer mouse model [1].