sirtuin-1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T12922	Sirtuin modulator 1	SRT3025 Hydrochloride	Sirtuin
	Sirtuin modulator 1 (SRT3025 Hydrochloride) is a modulator of SIRT1 with EC1.5 of < 1 μM.		Sirtuin
T79903	Sirtuin-1 inhibitor 1		Sirtuin
	Sirtuin-1 inhibitor 1 is an inhibitor against deacetylase-1 (Sirtuin-1) and can be used to study senescence and cell death in the organism.		Sirtuin
T5618	AK-1		Sirtuin
	AK-1 is a sirtuin 2 (SIRT2) inhibitor (IC50:12.5 µM).that prevents hippocampal neurodegeneration in Alzheimer's disease models and induces cell cycle arrest in colon carcinoma cells.		Sirtuin
T12918	SIRT-IN-1		Sirtuin
	SIRT-IN-1 is a potent SIRT1/2/3 inhibitor(IC50s of 15, 10, 33 μM, respectively).		Sirtuin
T9648	SIRT1-IN-1		Antiviral , Sirtuin
	SIRT1-IN-1 is a selective inhibitor of SIRT1 with an IC50 of 205 nM. SIRT1-IN-1 is an inhibitor of cytomegalovirus (CMV) with antiviral activity.		Antiviral , Sirtuin
T1919	Tenovin-1	Tenovin 1	Mdm2 , Dehydrogenase , Sirtuin , p53 , Autophagy
	Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.		Mdm2 , Dehydrogenase , Sirtuin , p53 , Autophagy
T4328	OSS_128167	SIRT6-IN-1	HBV , Sirtuin
	OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM).		HBV , Sirtuin
T6671	Sirtinol		Apoptosis , Sirtuin , Autophagy
	Sirtinol is a selective SIRT1/2 inhibitor (IC50: 131/38 μM).		Apoptosis , Sirtuin , Autophagy
T9320	YK-3-237	B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid	Sirtuin
	YK-3-237 (B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid) reduces acetylation of mtp53 and exhibits anti-proliferative effects toward triple-negative breast cancer (TNBC) cells ca...		Sirtuin
T5096	SRT 1720		Sirtuin , Autophagy
	SRT 1720 is a selective activator of human SIRT1 (EC1.5: 0.16 μM) and is >230-fold less potent for SIRT2 and SIRT3.		Sirtuin , Autophagy
T8346	SRT 1460	SRT1460	Sirtuin
	SRT 1460 is a SIRT1 activator.		Sirtuin
T22595	B2	Linazolamide intermediate B impurity 2,CPNQ,5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline	Others , Sirtuin
	B2 (Linazolamide intermediate B impurity 2) promotes inclusion formation in cellular models of Huntington's disease and Parkinson's disease		Others , Sirtuin
T7058	Selisistat S-enantiomer	EX-527 S-enantiomer,EX-527 (S-enantiomer)	Sirtuin
	Selisistat S-enantiomer (EX-527 S-enantiomer) is an effective and specific SIRT1 inhibitor (IC50 = 98 nM) and shows >200-fold selectivity against SIRT2/3.		Sirtuin
T12920	Sirt2-IN-1		Sirtuin
	Sirt2-IN-1 is an inhibitor of sirtuin 2 (IC50 = 163 nM).		Sirtuin
T77653	Z26395438		Sirtuin
	Z26395438 is an inhibitor of Sirtuin-1 with IC50 of 1.6 μM.		Sirtuin
T12921	SIRT5 inhibitor 1		Sirtuin
	SIRT5 inhibitor 1 is a potent and selective inhibitor of human Sirtuin 5 deacylase (IC50: 0.11 μM). sIRT5 inhibitor 1 is associated with ageing-related diseases.		Sirtuin
T21679	4'-bromo-Resveratrol		Sirtuin
	4'-bromo-Resveratrolis a potent inhibitor of the deacetylases sirtuin 1 (SIRT1) and 3 (SIRT3)		Sirtuin
T16932	SRT 2183		Apoptosis , Sirtuin
	SRT 2183 is a selective activator of Sirtuin-1 (SIRT1, EC1.5 : 0.36 μM).		Apoptosis , Sirtuin
Fr13587	7-Chloro-4-(piperazin-1-yl)quinoline
	7-Chloro-4-(piperazin-1-yl)quinolone is an important scaffold in medicinal chemistry. It exhibited either alone or as hybrid with other active pharmacophores diverse pharmacological profiles. 7-Chloro-4-(piperazin-1-yl)q...
T4S0800	Demethyleneberberine		P450 , NOS , NF-κB , HIF , AMPK
	Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria either in vitro or in vivo.Demethyleneberberine suppresses CYP2E1,...		P450 , NOS , NF-κB , HIF , AMPK