stat5 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T4216	STAT5-IN-1	STAT5 Inhibitor	STAT
	STAT5-IN-1 (STAT5 Inhibitor) is a cell-permeable inhibitor which suppresses Stat5 via binding to the SH2 domain.		STAT
T16940	STAT5-IN-2		Apoptosis , STAT
	STAT5-IN-2 is an inhibitor of STAT5 with antileukemic effects (EC50s: 9 μM and 5 μM in K562 and KU812 cells, respectively).		Apoptosis , STAT
T9209	PF-05221304	STAT5 Inhibitor III,NSC 170984,R 6238,,Clesacostat	Acetyl-CoA Carboxylase
	PF-05221304 (NSC-170984) is an orally active, liver-targeted inhibitor of acetyl-CoA carboxylase (ACC), a rate-limiting enzymes for fatty acid synthesis.		Acetyl-CoA Carboxylase
T8494	NS-3-008 hydrochloride	NS-3-008 HCl	Others
	NS-3-008 hydrochloride (NS-3-008 HCl) is a transcriptional G0/G1 switch 2 (G0s2) inhibitor( IC50 of 2.25 μM).		Others
T1995	Fedratinib	TG-101348,SAR 302503	Apoptosis , FLT , c-RET , JAK
	Fedratinib (TG-101348) (TG101348) is an ATP-competitive inhibitor of JAK2 (IC50: 3 nM) with significantly less potent activity against JAK3.		Apoptosis , FLT , c-RET , JAK
T9251	Fedratinib hydrochloride hydrate	TG-101348 hydrochloride hydrate,SAR 302503 hydrochloride hydrate	Apoptosis , JAK
	Fedratinib hydrochloride hydrate (SAR 302503 hydrochloride hydrate) is a potent, selective, ATP-competitive and orally active JAK2 inhibitor.		Apoptosis , JAK
T21267	HODHBt		STAT
	HODHBt is a STAT5-SUMO protein-protein interaction inhibitor.		STAT
T8546	BD750		JAK , STAT
	BD750 is an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation(IC50 of 1.5 μM and 1.1 μM in mouse and human T cells, respectively)		JAK , STAT
T6669	SH-4-54		STAT
	SH-4-54 is a most potent, small molecule, nonphosphorylated STAT3 inhibitor.		STAT
T27650	JAK3i	JAK-3i,JAK 3i	JAK
	JAK3i is a selective covalent inhibitor of JAK3 kinase. JAK3i reveals two distinct temporal waves of STAT5 phosphorylation and more potently targets the second wave, which is required for cell cycle progression and T cel...		JAK
TP1433	CMD178 TFA		STAT
	CMD178 (TFA) is a lead peptide that consistently reduces the expression of Foxp3 and STAT5 induced by IL-2/s IL-2Rα signaling.		STAT
T72029	CDK8-IN-13		Apoptosis , CDK
	CDK8-IN-13 is a CDK8 inhibitor (IC50: 51.9 nM) with potent, selective and oral activity. CDK8-IN-13 induces apoptosis and reduces the expression of p-STAT1 S727 and p-STAT5 S726. CDK8-IN-13 exhibits anti-tumour activity...		Apoptosis , CDK
T2814	Cryptotanshinone	Cryptotanshinon,Tanshinone c	STAT , Autophagy
	Cryptotanshinone (Cryptotanshinon), a STAT3 inhibitor (IC50: 4.6 μM) in a cell-free assay, strongly inhibits phosphorylation of STAT3 Tyr705, with a little effect on STAT3 Ser727, but no inhibition for STAT1 nor STAT5.		STAT , Autophagy
T9428	HM43239		FLT
	HM43239 is an orally active and selective FLT3 inhibitor with IC 50 s of 1.1 nM, 1.8 nM and 1.0 nM for FLT3 WT, FLT3 internal tandem duplication (ITD) and FLT3 D835Y kinases, respectively. HM43239 directly inhibits the k...		FLT
T67894	Butyzamide		Thrombopoietin Receptor , JAK
	Butyzamide is an effective and oral Mpl activator. It is a novel non-peptide-based molecule with antagonistic effects on thrombopoietin (TPO) receptors, which promotes proliferation of human Mpl (hMpl) expression and mou...		Thrombopoietin Receptor , JAK
T7101	Tyrphostin AG30	Tyrphostin AG30(AG30)	EGFR , Tyrosine Kinases
	Tyrphostin AG30 (AG30) (AG30) is a potent protein tyrosine kinases (PTK) inhibitor.		EGFR , Tyrosine Kinases
T8378	AS2863619		CDK , STAT
	AS2863619 is an orally active inhibitor of cyclin-dependent kinase 8 (CDK8) and CDK19 (IC50s of 0.61 nM and 4.28 nM, respectively).		CDK , STAT
T3072	XL019		Apoptosis , FLT , JAK , PDGFR
	XL019 is a potent and selective JAK2 inhibitor with IC50 of 2.2 nM, 100 fold selectivity over JAK1.		Apoptosis , FLT , JAK , PDGFR
TQ0037	Abrocitinib	PF-04965842	JAK
	Abrocitinib (PF-04965842) (PF-04965842) is a potent, specific and orally-active JAK1 inhibitor (IC50s: 29/803 nM for JAK1/2).		JAK
T2156	WP1066		Apoptosis , JAK , STAT
	WP1066 is a inhibitor of JAK2 (IC50: 2.30 μM) and STAT3 (IC50: 2.43 μM) in HEL cells; shows activity to JAK2, STAT3/5, and ERK1/2, not JAK1 and JAK3. WP1066 has been used in trials studying the treatment of Melanoma, Bra...		Apoptosis , JAK , STAT