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JAK3i

Catalog No. T27650 CAS 1918238-72-8

Synonyms: JAK-3i, JAK 3i

JAK3i is a selective covalent inhibitor of JAK3 kinase. JAK3i reveals two distinct temporal waves of STAT5 phosphorylation and more potently targets the second wave, which is required for cell cycle progression and T cell proliferation.

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JAK3i, CAS 1918238-72-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 350.00
5 mg	In stock	$ 828.00
10 mg	In stock	$ 1,130.00
25 mg	In stock	$ 1,590.00
50 mg	In stock	$ 1,980.00
1 mL * 10 mM (in DMSO)	In stock	$ 697.00

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Purity: 99.81%

Biological Description

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Description

In vitro

We targeted the key downstream IL2R-intermediate JAK 3 using a clinically relevant highly specific JAK3-inhibitor (JAK3i; PF-06651600) that potently inhibited STAT5-phosphorylation in vitro. Low-dose JAK3i combined with cellular and peptide vaccine strategies further decreased tumor load compared with both monotherapies alone.[1] The subsequent phenotype ontology results have revealed JAK3I, PLCG2, and ZEB2 as key hub genes contributing to the inflammation underlying cardiovascular and immune response related phenotypes.[2]

Synonyms	JAK-3i, JAK 3i
Molecular Weight	354.34
Formula	C18H15FN4O3
CAS No.	1918238-72-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mg/mL (28.22 mM)

References and Literature

1. Dammeijer F, et al. Low-Dose JAK3 Inhibition Improves Antitumor T-Cell Immunity and Immunotherapy Efficacy. Mol Cancer Ther. 2022;21(9):1393-1405. 2. Awan Z, et al. Identifying significant genes and functionally enriched pathways in familial hypercholesterolemia using integrated gene co-expression network analysis. Saudi J Biol Sci. 2022;29(5):3287-3299. 3. Smith GA, et al. Essential biphasic role for JAK3 catalytic activity in IL-2 receptor signaling. Nat Chem Biol. 2016;12(5):373-379.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Inhibitor Library Kinase Inhibitor Library Bioactive Compound Library Bioactive Compounds Library Max Anti-Cancer Compound Library

Related Products

Related compounds with same targets

Ganoderic acid B BD750 JAK3/BTK-IN-1 JAK-IN-10 Lorpucitinib JAK-IN-30 JAK-IN-31 TAK-901

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

JAK3i 1918238-72-8 Angiogenesis Chromatin/Epigenetic JAK/STAT signaling Stem Cells JAK JAK-3i JAK 3i inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.