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PF-05221304

Catalog No. T9209   CAS 1370448-25-1
Synonyms: STAT5 Inhibitor III, NSC 170984, R 6238,, Clesacostat

PF-05221304 (NSC-170984) is an orally active, liver-targeted inhibitor of acetyl-CoA carboxylase (ACC), a rate-limiting enzymes for fatty acid synthesis.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
PF-05221304 Chemical Structure
PF-05221304, CAS 1370448-25-1
Pack Size Availability Price/USD Quantity
1 mg In stock $ 143.00
5 mg In stock $ 293.00
10 mg In stock $ 441.00
25 mg In stock $ 767.00
50 mg In stock $ 996.00
100 mg In stock $ 1,450.00
200 mg In stock $ 1,950.00
500 mg In stock $ 2,890.00
1 mL * 10 mM (in DMSO) In stock $ 447.00
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Purity: 99.19%
Purity: 98.82%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description PF-05221304 (NSC-170984) is an orally active, liver-targeted inhibitor of acetyl-CoA carboxylase (ACC), a rate-limiting enzymes for fatty acid synthesis.
In vitro PF-05221304 blocked polarization of human T cells to proinflammatory but not anti-inflammatory T cells, and suppressed activation of primary human stellate cells to myofibroblasts in vitro, showing direct effects on inflammation and fibrogenesis[1].
In vivo PF-05221304 reduced markers of inflammation and fibrosis in the diethylnitrosamine chemical-induced liver injury model and the choline-deficient, high-fat-fed rat model[1].
Synonyms STAT5 Inhibitor III, NSC 170984, R 6238,, Clesacostat
Molecular Weight 502.56
Formula C28H30N4O5
CAS No. 1370448-25-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 95mg/ml(189.03mM)

ethanol: 5mg/ml(9.95mM)

TargetMolReferences and Literature

1. Ross T T , Crowley C , Kelly K L , et al. Acetyl-CoA Carboxylase Inhibition Improves Multiple Dimensions of NASH Pathogenesis in Model Systems[J]. Cellular and Molecular Gastroenterology and Hepatology, 2020, 10(4).

Related compound libraries

This product is contained In the following compound libraries:
Lipid Metabolism Compound Library Clinical Compound Library Drug Repurposing Compound Library Metabolism Compound Library Inhibitor Library NO PAINS Compound Library Bioactive Compound Library Anti-Obesity Compound Library Orally Active Compound Library Bioactive Compounds Library Max

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Quizalofop-P PF-05175157 TOFA ND-646 CMS-121 CP-640186 hydrochloride Tralkoxydim Olumacostat Glasaretil

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Keywords

PF-05221304 1370448-25-1 Metabolism Acetyl-CoA Carboxylase STAT5 Inhibitor III NSC 170984 PF 05221304 PF05221304 NSC170984 R 6238, NSC-170984 Clesacostat inhibitor inhibit

 

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