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STAT5-IN-1

Catalog No. T4216 CAS 285986-31-4

Synonyms: STAT5 Inhibitor

STAT5-IN-1 (STAT5 Inhibitor) is a cell-permeable inhibitor which suppresses Stat5 via binding to the SH2 domain.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

STAT5-IN-1, CAS 285986-31-4

Pack Size	Availability	Price/USD
5 mg	In stock	$ 47.00
10 mg	In stock	$ 86.00
25 mg	In stock	$ 183.00
50 mg	In stock	$ 322.00
100 mg	In stock	$ 547.00
1 mL * 10 mM (in DMSO)	In stock	$ 47.00

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Purity: 99.92%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	STAT5-IN-1 (STAT5 Inhibitor) is a cell-permeable inhibitor which suppresses Stat5 via binding to the SH2 domain.
Targets&IC50	STAT5:47 μM
In vitro	The chemical compound STAT5-IN-1 serves as an inhibitor of Signal Transducer and Activator of Transcription 5 (STAT5), a protein crucial for cell growth and differentiation. By attaching to the SH2 domain of STAT5, it selectively impedes its activity. While it also affects STAT3, STAT1, and the Lck tyrosine kinase, this inhibition is significantly less pronounced (IC50 > 500 μM). Additionally, STAT5-IN-1 effectively prevents the interaction between STAT5 and DNA within K562 nuclear extracts. Notably, modifying the chromone ring's C6 hydrogen to an ethyl group in STAT5-IN-1 does not diminish its efficacy against STAT5β; however, it eradicates its selectivity towards other STAT family members.

Synonyms	STAT5 Inhibitor
Molecular Weight	293.28
Formula	C16H11N3O3
CAS No.	285986-31-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (170.49 mM)

References and Literature

1. Müller J, et al. Discovery of chromone-based inhibitors of the transcription factor STAT5. Chembiochem. 2008 Mar 25;9(5):723-7. 2. Chen C, Lu M, Lin S, et al. The nuclear gene rpl18 regulates erythroid maturation via JAK2-STAT3 signaling in zebrafish model of Diamond–Blackfan anemia[J]. Cell Death & Disease. 2020, 11(2): 1-11.

Citations

1. Chen C, Lu M, Lin S, et al. The nuclear gene rpl18 regulates erythroid maturation via JAK2-STAT3 signaling in zebrafish model of Diamond–Blackfan anemia. Cell Death & Disease. 2020, 11(2): 1-11

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library NO PAINS Compound Library Bioactive Compound Library Anti-Cancer Compound Library Anti-Aging Compound Library Reprogramming Compound Library Anti-Cancer Metabolism Compound Library Anti-Liver Cancer Compound Library Anti-Lung Cancer Compound Library Apoptosis Compound Library

Related Products

Related compounds with same targets

SH-4-54 Homoharringtonine SH5-07 RSVA405 Boehmenan Jolkinolide B STAT3 degrader-2 Stafib-1

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

STAT5-IN-1 285986-31-4 JAK/STAT signaling Stem Cells STAT STAT-5-IN-1 STAT5IN1 inhibit STAT5 IN 1 STAT5 Inhibitor Inhibitor inhibitor

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