sk-1-in-1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T12927	SK1-IN-1		S1P Receptor
	SK1-IN-1 is a potent inhibitor of sphingosine kinase 1 (SPHK1)(IC50 of 58 nM).		S1P Receptor
T4612	NS309		EGFR , Potassium Channel , HER
	NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 µM for SK channels and 10-90 nM for IK channels). It can also activat...		EGFR , Potassium Channel , HER
T3S1589	Notoginsenoside Fa		Others
	1. Notoginsenosides Fa and R4 show significant neurite outgrowth enhancing activities in human neuroblastoma SK-N-SH cells.		Others
T6S1487	Ginsenoside Rg5		NF-κB , COX , IGF-1R
	1. Ginsenoside Rg5 could be a beneficial agent for the treatment of Alzheimer's disease. 2. Ginsenoside Rg5 suppresses LPS-induced nitric oxide (NO) production and proinflammatory TNF-α secretion. 3. Ginsenoside Rg5 can ...		NF-κB , COX , IGF-1R
T74558	SK-575-NEG
	SK-575-NEG (compound 28), a methylated derivative of SK-575, results from the methylation of the piperidine-2,6-dione's amino group in SK-575, serving as a control compound. It exhibits strong binding affinity to PARP1, ...
TN4373	Kaempferol tetraacetate		Antifection
	Kaempferol tetraacetate is a potent antiplatelet agent. It exhibits significant cytotoxicity in vitro against three human cell lines HL-60, U937 and SK-MEL-1.		Antifection
T28788	SK-216	SK216.Plasminogen activator inhibitor-1 (PAI-1) inhibitor
	SK-216 is a specific PAI-1 inhibitor. SK-216 reduced the extent of angiogenesis in the tumors and inhibited VEGF-induced migration and tube formation by human umbilical vein endothelial cells in vitro. SK-216 reduced the...
T80170	Tamapin		Potassium Channel
	Tamapin, a venom peptide isolated from the Indian red scorpion (Mesobuthus tamulus) [1], selectively targets and blocks small-conductance Ca(2+)-activated K(+) (SK) channels, particularily SK2 (Potassium Channel). It inh...		Potassium Channel
T74662	UBA5-IN-1
	UBA5-IN-1 (compound 8.5) is a selective inhibitor of UBA5, demonstrating an IC50 of 4.0 μM. It effectively inhibits cell proliferation in Sk-Luci6 cancer cells, which exhibit high expression levels of UBA5 [1].
T80924	Tubulin polymerization-IN-51
	Tubulin Polymerization-IN-51 (compound 7u) serves as a tubulin polymerization inhibitor, exhibiting an IC50 range of 2.55 - 17.89μM against SK-Mel-28 cells, and is applicable in cancer research [1].
T74781	UT-11
	UT-11 is a potent brain-permeable inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1), exhibiting IC50 values of 0.10 μM and 2.00 μM for the inhibition of PGE2 production in human (SK-N-AS) and murine (BV2) cell...
T80171	Tamapin TFA		Potassium Channel
	Tamapin TFA, a venom peptide isolated from the Indian red scorpion (Mesobuthus tamulus) [1], selectively targets and blocks small conductance Ca(2+)-activated K(+) (SK) channels, particularly the SK2 subtype (Potassium C...		Potassium Channel
T36427	PACAP (6-27) (human, chicken, mouse, ovine, porcine, rat) (trifluoroacetate salt)		PACAP
	Pituitary adenylate cyclase-activating peptide (PACAP) (6-27) is a PACAP receptor antagonist with IC50 values of 1,500, 600, and 300 nM, respectively, for rat PAC1, rat VPAC1, and human VPAC2 recombinant receptors expres...		PACAP
TN6014	Norcepharadione B
	Norcepharadione B shows good inhibitory activity against the replication of HSV-1, it also shows antimalarial activity with EC50 values of 7.5mug/ml. Norcepharadione B exhibits significant cytotoxicity against five human...
T60603	BRD9500
	BRD9500 is an orally active inhibitor of phosphodiesterases 3 (PDE3) with IC 50 s of 10 and 27 nM for PDE3A and PDE3B, respectively. BRD9500 is active in an SK-MEL-3 xenograft model of cancer [1].
T74491	Antitumor agent-61
	Antitumor agent-61 (Compound 9b), an Irinotecan (Ir) derivative, demonstrates potent anticancer activity, as evidenced by its IC50 values ranging from 0.92 to 3.23 μM against six human cancer cell lines: SK-OV-3, SK-OV-3...
T79429	Tubulin polymerization-IN-50
	Tubulin Polymerization-IN-50 (compound 7n) serves as an inhibitor of tubulin polymerization, exhibiting an IC50 of 5.05 μM in SK-Mel-28 cells and inducing cell cycle arrest at the G2/M phase [1].
T76184	Scyllatoxin
	Scyllatoxin (Leiurotoxin I), a peptide toxin derived from the venom of the scorpion (Leiurus quinquestriatus hebraeus), acts as a blocker of small-conductance K Ca (SK) channels. It notably enhances the release of norepi...
T35977	6α-hydroxy Cholesterol	6α-hydroxy Cholesterol,6α-OHC
	6α-hydroxy Cholesterol is an oxysterol that increases superoxide anion production in SK-N-BE cells when used at concentrations of 50 and 100 μM.[1]
T70789	VPC03090
	VPC03090 is a Sphingosine-1-Phosphate Receptor Inhibitor. VPC03090 is an analog of FTY-720, acts as antagonist for S1PR1 and S1PR3. VPC03090-P, converted from VPC03090 through the phosphorylation by SK-2, causes a reduct...