polygalaceae — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TN2865	(E)-3,4,5-Trimethoxycinnamic acid	O-Methylsinapic acid,3,4,5-Trimethoxy-trans-cinnamic acid,3,4,5-Trimethoxyphenylacrylic acid	Others
	(E)-3,4,5-Trimethoxycinnamic acid (O-Methylsinapic acid) is a natural product from the roots and rhizomes of Notopterygium incisum.		Others
T81281	Rhamnetin 3-O-β-D-glucopyranoside
	Rhamnetin 3-O-β-D-glucopyranoside, a flavonoid derivative, is isolated from the roots of Polygala sibirica L. (Polygalaceae) [1].
T5147	Polygalaxanthone XI		Others
	Polygalaxanthone XI, an oxygenated xanthone glycoside isolated from the cortex of Polygala tenuifolia, is utilized in research for its expectorant properties and potential to promote mental tranquility.		Others
T3769	Tenuifolin		Others , Beta-Secretase , AChE
	Tenuifolin has no inherent toxicity to either the transfected or wild type cells at the effective concentrations, it inhibits amyloid-β secretion in vitro.		Others , Beta-Secretase , AChE
T3856	Tenuifoliside A		ERK , Others
	Tenuifoliside A has anti-apoptotic , neuroprotective activity. And tenuifoliside A has anti-inflammatory effect, which is mediated by the inhibition of the NF-κB and MAPK pathways.		ERK , Others
T5702	Tenuifoliside B		Dehydrogenase
	Tenuifoliside B is a natural product from the roots of Polygala tenuifolia.And is a target lactate dehydrogenase inhibitor. Tenuifoliside B has cognitive improving and cerebral protective effects. it can inhibit potassi...		Dehydrogenase
T5S2205	Sibiricaxanthone B		Others
	Sibiricaxanthone B is an oxygen-containing xanthone isolated from Polygala tenuifolia.		Others
T5705	Glomeratose A		Dehydrogenase
	Glomeratose A is a lactate dehydrogenase inhibitor.		Dehydrogenase
T5S2207	7-O-Methylmangiferin		Others
	7-O-MethylMangiferin is an xanthone isolated from the rhizomes of Iris nigricans.		Others
T5S2195	Sibiricose A5		Dehydrogenase
	Sibiricose A5 is a lactate dehydrogenase inhibitor, it displays antidepressant-like, and antioxidant actions. Sibiricose A5 can protect PC12 cells damage induced by P. tenuifolia.		Dehydrogenase
TN1140	Onjisaponin B		AMPK , mTOR , Autophagy
	Onjisaponin B induces autophagy via the AMPK-mTOR signaling pathway, increases the NGF level and accelerates both the removal of mutant huntingtin and A53T α±-synuclein, it may have potential therapeutic effects on Parki...		AMPK , mTOR , Autophagy
T4S0675	Polygalasaponin V		Others
	Polygalasaponin possesses evident anxiolytic and sedative-hypnotic activities and has a relatively safe dose range, which supports the use of Polygala tenuifolia root as an anxiolytic and sedative-hypnotic drug in folk m...		Others
T3826	Polygalasaponin F		NF-κB , TLR , Akt , PI3K
	Polygalasaponin F has anti-neuroinflammatory activity, can inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and reduce the expression of inducible nitric oxide synthases. Po...		NF-κB , TLR , Akt , PI3K
T2S2211	Tenuifoliside C		Dehydrogenase
	Tenuifoliside C, isolated from polygala tenuifolia willd, is a target lactate dehydrogenase inhibitor. It significantly inhibits chlorzoxazone 6-hydroxylation catalyzed by CYP2E1[1].		Dehydrogenase
T3696	Polygalaxanthone III		Others , P450
	Polygalaxanthone III can significantly inhibit chlorzoxazone 6-hydroxylation catalyzed by CYP2E1.		Others , P450
T3907	Tenuigenin	Senegenin,Senegin	NF-κB , Caspase , Antibacterial
	Tenuigenin (Senegenin) is a natural product from Polygala tenuifolia used in Chinese medicine with antioxidative and anti-inflammatory activity.		NF-κB , Caspase , Antibacterial
T5S2204	Sibiricose A6		Antioxidant
	1. Sibiricose A6 displays antidepressant-like action, it may prevent or relieve depression. 2. Sibiricose A6 shows potent antioxidant activity.		Antioxidant
T3697	3',6-Disinapoylsucrose	Disinapoyl sucrose,3,6'-Disinapoyl sucrose	BCL , Epigenetic Reader Domain
	3',6-Disinapoylsucrose (Disinapoyl sucrose) shows the neuroprotective effect and antidepressive activity in rats.		BCL , Epigenetic Reader Domain