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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T10505 | PPARα-MO-1 | PPAR | |
PPARα-MO-1 is a potent modulator of PPARα. | |||
T62968 | PPARα/δ agonist 1 | ||
PPARα/δ agonist 1 is a potent PPARα/PPARδ dual agonist with EC50 values of 7.0 nM for PPARα and 8.4 nM for PPARδ. PPARα/δ agonist 1 exhibits high selectivity for PPARγ (EC50: 1316.1 nM). agonist 1 has potential for non-a... | |||
T62266 | PPARα agonist 1 | ||
PPARα agonist 1 is a complete and potent PPARα agonist. | |||
T60535 | PPARα/γ agonist 1 | ||
PPARα/γ agonist 1 is a potent and dual PPARα/γ partial agonist which is a promising prototype for the research of dyslipidemia and diabetes. PPARα/γ agonist 1 has EC50 values of 28 nM and 69 nM for PPARα and PPARγ, respe... | |||
T14933 | Cetaben | Others | |
Cetaben is a PPARα-independent peroxisome proliferator and is a non-fibrate hypolipidemic drug. It potent reduces the concentration of cholesterol and triglycerides. | |||
T7052 | Gnetol | Tyrosinase , COX , HDAC , AChR | |
Gnetol competitivity inhibits butyrylcholinesterase (IC50: 1.3 uM). Gnetol has a strong inhibitory effect on murine tyrosinase activity. Gnetol significantly suppresses melanin biosynthesis in murine B16 melanoma cells. ... | |||
T10900 | CUDA | PPAR , Epoxide Hydrolase | |
CUDA is an effective soluble cyclohydrolase inhibitor with IC50 of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively. CUDA selectively increases the activity of peroxisome proliferator-activated receptor (PPAR... | |||
T4328 | OSS_128167 | SIRT6-IN-1 | HBV , Sirtuin |
OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM). | |||
T15821 | LY518674 | LY-674 | PPAR |
LY518674 (LY-674) decreases triglycerides and increases HDL-C and is used for the treatment of atherosclerosis. LY518674 is an effective and selective PPARα agonist (EC50: 42 nM for human PPARα). | |||
T6893 | MK-886 | MK886,L 663536 | Apoptosis , Leukotriene Receptor , COX , PPAR , FLAP |
MK-886 (L 663536) is an inhibitor of leukotriene biosynthesis, inhibiting 5-lipoxygenase-activating protein (FLAP). It is also a moderately potent PPARα antagonist. | |||
T15453 | GW7647 | PPAR | |
GW7647 is a potent agonist of PPARα (EC50s: 6 nM, 1.1 μM, and 6.2 μM for human PPARα, PPARγ, and PPARδ, respectively). | |||
T8374 | LJ570 | PPAR | |
LJ570 is the first PPARα/γ dual agonist (PPARα,PPARγ with EC50s of 1.05 and 0.12 μM, respectively[) | |||
T17044 | Tesaglitazar | PPAR | |
Tesaglitazar is a potent and selective peroxide PPARα / γ receptor dual agonist with a more potent affinity for PPARγ than PPARα, The EC50 values for rat PPARα and human PPARα were 13.4 μM and 3.6 μM, respectively, and 0... | |||
T8699 | GFT505 | Elafibranor | PPAR |
GFT505 (Elafibranor) (Elafibranor) is a PPARα/δ agonist with EC50s of 45 and 175 nM, respectively. | |||
TQ0120 | CDDO-Im | RTA-403,CDDO-Imidazolide,TP-235 | Others , Ferroptosis , Nrf2 , PPAR |
CDDO-Im (TP-235) is an activator of Nrf2 and PPAR (Kis: 232/344 nM for PPARα/PPARγ). | |||
TQ0107 | Pemafibrate | (R)-K-13675 | PPAR |
Pemafibrate ((R)-K-13675) is a highly specific PPARα agonist (EC50: 1 nM). | |||
T14176 | Aleglitazar | RO0728804,R1439 | PPAR |
Aleglitazar (R1439) (R1439) is a potent dual PPARα/γ agonist, with IC50s of 38 nM and 19 nM for human PPARa and PPARγ, respectively. Aleglitazar can be used for the research of type II diabetes. | |||
T12835 | Saroglitazar | Lipaglyn | PPAR |
Saroglitazar (Lipaglyn) is an agonist of PPAR with EC50 values of 0.65 pM and 3 nM for PPARα and PPARγ. | |||
T7395 | Lanifibranor | IVA337 | PPAR |
Lanifibranor (IVA337) is an agonist of peroxisome proliferator-activated receptors (PPARs) with EC50 values of 1,537, 866, and 206 nM for human recombinant PPARα, PPARβ, and PPARγ, respectively, for transactivation activ... | |||
T12834 | Saroglitazar Magnesium | Others | |
Saroglitazar Magnesium is a novel peroxissome proliferator-activated receptor (PPAR) agonist with significant activation activity against PPARα (EC50 0.65pM) and moderate activation against PPARγ (EC50 3 nM). |