Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Aleglitazar (R1439) (R1439) is a potent dual PPARα/γ agonist, with IC50s of 38 nM and 19 nM for human PPARa and PPARγ, respectively. Aleglitazar can be used for the research of type II diabetes.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 258.00 | |
5 mg | In stock | $ 592.00 | |
10 mg | In stock | $ 798.00 | |
25 mg | In stock | $ 1,220.00 | |
50 mg | In stock | $ 1,650.00 | |
100 mg | In stock | $ 2,220.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 598.00 |
Description | Aleglitazar (R1439) (R1439) is a potent dual PPARα/γ agonist, with IC50s of 38 nM and 19 nM for human PPARa and PPARγ, respectively. Aleglitazar can be used for the research of type II diabetes. |
Targets&IC50 | PPARγ:19 nM, PPARα:38 nM |
In vitro | Aleglitazar exhibits species selectivity with respect to PPARα, with an EC50s of 50 nM, 2.26 µM and 2.34 µM for human PPARα, rat PPARα and mouse PPARα, respectively[1]. Aleglitazar (0.01-40 µM; 12-48 hours) does not significantly increase lactate dehydrogenase (LDH) release at concentrations of 0.1 µM to 20 µM, but significant increases LDH release at concentrations of 30 µM and 40 µM[2]. Aleglitazar (0.01-20 µM; 48 hours) decreases hyperglycaemic conditions (HG, glucose 25 mM)-induced apoptosis, caspase-3 activity and cytochrome-C release[2]. Aleglitazar improves cell viability in cells exposed to hyperglycaemia[2]. |
In vivo | Aleglitazar (0.3-3.0 mg/kg; i.p.; daily; for 7 days) exerts beneficial effects on structural and functional outcomes of mild brain ischemia[3]. Aleglitazar reduces key aspects of microglia activation including NO production, release of proinflammatory cytokines, migration, and phagocytosis[3]. Aleglitazar attenuates inflammatory responses in post-ischemic brain[3]. |
Synonyms | RO0728804, R1439 |
Molecular Weight | 437.51 |
Formula | C24H23NO5S |
CAS No. | 475479-34-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45mg/mL (102.9mM)
You can also refer to dose conversion for different animals. More
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Aleglitazar 475479-34-6 DNA Damage/DNA Repair Metabolism PPAR RO0728804 R1439 RO-0728804 RO 0728804 R-1439 R 1439 inhibitor inhibit