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Saroglitazar

Catalog No. T12835   CAS 495399-09-2
Synonyms: Lipaglyn

Saroglitazar is an agonist of PPAR with EC50 values of 0.65 pM and 3 nM for PPARα and PPARγ.

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Saroglitazar Chemical Structure
Saroglitazar, CAS 495399-09-2
Pack Size Availability Price/USD Quantity
1 mg In stock $ 153.00
2 mg In stock $ 212.00
5 mg In stock $ 327.00
10 mg In stock $ 497.00
25 mg In stock $ 793.00
50 mg In stock $ 1,130.00
100 mg In stock $ 1,520.00
1 mL * 10 mM (in DMSO) In stock $ 349.00
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Purity: 98%
Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Saroglitazar is an agonist of PPAR with EC50 values of 0.65 pM and 3 nM for PPARα and PPARγ.
Targets&IC50 PPARα:0.65 pM (EC50, HepG2 cell), PPARγ:3 nM (EC50, HepG2 cell)
In vivo In db/db mice, Saroglitazar (0.01-3 mg/kg; orally) reduces serum triglycerides, free fatty acids, and glucose in a dose-dependent manner (ED50 = 0.05, 0.19, and 0.19 mg/kg). Saroglitazar (1 mg/kg) significantly reduces serum insulin and AUC-glucose(91%)[3].
Synonyms Lipaglyn
Molecular Weight 439.57
Formula C25H29NO4S
CAS No. 495399-09-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: 22.5mg/mL (51.2mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Jain MR, et al. Saroglitazar, a novel PPARα/γ agonist with predominant PPARα activity, shows lipid-lowering and insulin-sensitizing effects in preclinical models. Pharmacol Res Perspect. 2015 Jun;3(3):e00136.

Related compound libraries

This product is contained In the following compound libraries:
Clinical Compound Library Mitochondria-Targeted Compound Library Drug Repurposing Compound Library Bioactive Compounds Library Max DNA Damage & Repair Compound Library Anti-Pancreatic Cancer Compound Library Nuclear Receptor Compound Library Bioactive Compound Library Anti-Cancer Compound Library Anti-Obesity Compound Library

Related Products

Related compounds with same targets
Mavodelpar free acid MSDC-0602K Tesaglitazar Daltroban Mavodelpar free acid hydrochloride Sulotroban Sulotroban potassium Cevoglitazar

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Keywords

Saroglitazar 495399-09-2 DNA Damage/DNA Repair Metabolism PPAR Lipaglyn inhibitor inhibit