Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Saroglitazar Magnesium is a novel peroxissome proliferator-activated receptor (PPAR) agonist with significant activation activity against PPARα (EC50 0.65pM) and moderate activation against PPARγ (EC50 3 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 147.00 | |
5 mg | In stock | $ 387.00 | |
10 mg | In stock | $ 597.00 | |
25 mg | In stock | $ 953.00 | |
50 mg | In stock | $ 1,290.00 | |
100 mg | In stock | $ 1,730.00 | |
500 mg | In stock | $ 3,490.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 592.00 |
Description | Saroglitazar Magnesium is a novel peroxissome proliferator-activated receptor (PPAR) agonist with significant activation activity against PPARα (EC50 0.65pM) and moderate activation against PPARγ (EC50 3 nM). |
Targets&IC50 | PPARγ:3 nM (EC50, HepG2 cell), PPARα:0.65 pM (EC50, HepG2 cell) |
In vivo | In db/db mice, Saroglitazar (0.01-3 mg/kg per day, orally) treatment with 12-day causes dose-dependent reductions in serum triglycerides (TG), free fatty acids (FFA), and glucose. The ED50 for these effects is found to be 0.05, 0.19, and 0.19 mg/kg, respectively with highly significant (91%) reduction in serum insulin and AUC-glucose following oral glucose administration (59%) at 1 mg/kg dose.in Wistar rats and marmosets A 90-day repeated dose comparative study confirms efficacy (TG lowering) potential of Saroglitazar and has indicated low risk of PPAR-associated side effects in humans. Based on efficacy and safety profile, Saroglitazar appears to have good potential as novel therapeutic agent for treatment of dyslipidemia and diabetes[1]. |
Molecular Weight | 901.43 |
Formula | C50H56MgN2O8S2 |
CAS No. | 1639792-20-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 112.5 mg/mL (124.8 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Saroglitazar Magnesium 1639792-20-3 Others inhibitor inhibit