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Search Results for " p-erk1/2 "

10

Compounds

Cat No.	Product Name	Synonyms	Targets
T6308	Stattic	STAT3 Inhibitor V	Apoptosis , STAT
	Stattic (STAT3 Inhibitor V) is a STAT3 inhibitor (IC50=5.1 μM) that selectively inhibits STAT3 activation, dimerization, and nuclear translocation. Stattic has antitumor activity and induces apoptosis.		Apoptosis , STAT
T6189	Mirdametinib	PD325901,PD0325901	Apoptosis , MEK , Autophagy
	Mirdametinib (PD325901) is an MEK inhibitor (IC50=0.33 nM) with selective, non-ATP-competitive, and oral activity. Mirdametinib exhibits antitumor activity by inhibiting p-ERK1/2 expression and inducing apoptosis.		Apoptosis , MEK , Autophagy
TL0016	Sulforaphene		Apoptosis , ERK , EGFR , NF-κB
	Sulforaphene is a natural product isolated from radish seeds, exhibits an ED50 against velvetleaf seedlings approximately 2 x 10 -4 M. Sulforaphene promotes cancer cells apoptosis and inhibits migration via inhibiting EG...		Apoptosis , ERK , EGFR , NF-κB
T41231	GP 1a		Cannabinoid Receptor , PERK , Arrestin
	GP 1a is a potent agonist of cannabinoid receptor 2 (CB2) (EC50=7.1), as shown in cAMP, GTPγS and β-arrestin recruitment assays. GP 1a is approximately 30-fold more selective for CB2 receptors than CB1 receptors and incr...		Cannabinoid Receptor , PERK , Arrestin
T3478	Ro 67-7476		GluR
	Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors. No activity at human mGlu1 receptors. Potentiates glutamate-induced calcium release with EC 50 of 60.1 nM.		GluR
T2698	Asperosaponin VI	Akebia saponin D,Asperosaponin Ⅵ	Apoptosis , Others , Caspase
	Asperosaponin VI (Akebia saponin D) , the most abundant constituent of the rhizome of Dipsacus asper, has been used for the treatment of lower back pain, traumatic hematoma and bone fractures.		Apoptosis , Others , Caspase
TN1211	2-Hydroxy-3-methylanthraquinone		ERK , p38 MAPK , Caspase
	2-Hydroxy-3-methylanthraquinone enhances apoptosis of U937 cells,in part,through activation of p-p38MAPK and downregulation of p-ERK1/2; triggers caspase-3 activation mediated apoptotic induction.		ERK , p38 MAPK , Caspase
T74833	EGFR T790M/L858R-IN-2
	EGFRT790M/L858R-IN-2 is a potent, selective inhibitor of EGFRT790M/L858R, exhibiting IC50 values of 3.5 nM for EGFRT790M/L858R and 1290 nM for EGFR WT. This compound effectively decreases the expression of p-EGFR, P-AKT,...
T38446	ROC-0929
	ROC-0929 (compound 13a) is a potent and selective inhibitor of secreted phospholipases A2 (sPLA2s), effectively targeting hGX with an IC50 of 80 nM. It efficiently inhibits the phosphorylation of ERK1/2 and p-38. sPLA2s,...
T37295	Ganglioside GM1 Asialo Mixture
	Ganglioside GM1 asialo is a component of cellular lipid rafts and can be formed by the cleavage of the sialic acid residue from ganglioside GM1 by neuraminidase. Ganglioside GM1 asialo is a glycolipid receptor for P. aer...

Compounds

Synonym: STAT3 Inhibitor V

Target: Apoptosis, STAT

Synonym: PD325901,PD0325901

Target: Apoptosis, MEK, Autophagy

Target: Apoptosis, ERK, EGFR, NF-κB

Target: Cannabinoid Receptor, PERK, Arrestin

Asperosaponin VI

Synonym: Akebia saponin D,Asperosaponin Ⅵ

Target: Apoptosis, Others, Caspase

2-Hydroxy-3-methylanthraquinone

Target: ERK, p38 MAPK, Caspase

EGFR T790M/L858R-IN-2

Ganglioside GM1 Asialo Mixture

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