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Search Results for " notch1 "

10

Compounds

Cat No. Product Name Synonyms Targets
T3399 Psoralidin Others , Estrogen/progestogen Receptor , Reactive Oxygen Species , Lipoxygenase , Gamma-secretase , Akt , COX , Antibacterial
Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally. Psoralidin possesses anticancer and chemopreventive properties.
T1602 Valproic acid sodium salt Sodium Valproate Mitophagy , Gamma-secretase , HIV Protease , GABA Receptor , HDAC , Autophagy
Valproic acid sodium salt (Sodium Valproate) is the sodium salt form of valproic acid with anti-epileptic activity. Valproic acid sodium salt is converted into its active form, valproate ion, in blood. Although the mecha...
T6474 Divalproex Sodium Valproate semisodium,Epival HDAC
Divalproex Sodium (Valproate semisodium) binds to and inhibits gamma-aminobutyric acid (GABA) transaminase and its anticonvulsant activity may be exerted by increasing brain concentration of GABA and by inhibiting enzyme...
T7064 Valproic Acid Sodium valproate,2-Propylpentanoic Acid,VPA,Depakine,2-Propylvaleric Acid Mitophagy , Gamma-secretase , HIV Protease , GABA Receptor , Sodium Channel , HDAC , Autophagy
Valproic Acid (2-Propylpentanoic Acid) is an HDAC inhibitor that inhibits HDAC1 activity, induces HDAC2 degradation, and is orally active. Valproic Acid can be used in epilepsy and bipolar disorder research.
T14680 BMS-906024 Osugacestat,AL-101,BM-0018 Gamma-secretase
BMS-906024 (Osugacestat) is an orally available and selective inhibitor of γ-secretase, a small molecule Notch inhibitor.BMS-906024 has broad-spectrum antitumour activity against a variety of human cancer xenografts.BMS-...
T72984 (Rac)-SHIN2 Others
(Rac)-SHIN2 is a serine hydroxymethyltransferase (SHMT) inhibitor that enhances NOTCH1-driven in vivo survival of primary T-ALL in mice and can be used to study T-cell acute lymphoblastic leukemia (T-ALL).
T7522 GI254023X GI 254023X MMP , Immunology/Inflammation related
GI254023X is a potent MMP9 and ADAM10 inhibitor (IC50s: 2.5 and 5.3 nM) with 100-fold selectivity for the α-secretase ADAM10 over ADAM17 (TACE). GI254023X can remarkably inhibit the proliferation and induce the apoptosis...
T3633 Crenigacestat LY3039478 Gamma-secretase
Crenigacestat (LY3039478) is an orally bioavailable Notch inhibitor with an IC50 of ~1 nM in most of the tumor cell lines tested. Crenigacestat effectively inhibits mutant Notch receptor activity. In a xenograft tumor mo...
T76785 Brontictuzumab
Brontictuzumab (OMP 52M51), a monoclonal antibody (MAb), selectively targets and binds to the negative regulatory region of Notch1, inhibiting its signaling. This action inhibits tumor cell proliferation, rendering Bront...
T16341 Notch inhibitor 1 Others
Notch inhibitor 1 is an effective Notch inhibitor (IC50s: 7.8 and 8.5 nM for Notch 1 and Notch 3, respectively). Notch inhibitor 1 is also used in the research of cancer.
TargetMol