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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T3399 | Psoralidin | Others , Estrogen/progestogen Receptor , Reactive Oxygen Species , Lipoxygenase , Gamma-secretase , Akt , COX , Antibacterial | |
Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally. Psoralidin possesses anticancer and chemopreventive properties. | |||
T1602 | Valproic acid sodium salt | Sodium Valproate | Mitophagy , Gamma-secretase , HIV Protease , GABA Receptor , HDAC , Autophagy |
Valproic acid sodium salt (Sodium Valproate) is the sodium salt form of valproic acid with anti-epileptic activity. Valproic acid sodium salt is converted into its active form, valproate ion, in blood. Although the mecha... | |||
T6474 | Divalproex Sodium | Valproate semisodium,Epival | HDAC |
Divalproex Sodium (Valproate semisodium) binds to and inhibits gamma-aminobutyric acid (GABA) transaminase and its anticonvulsant activity may be exerted by increasing brain concentration of GABA and by inhibiting enzyme... | |||
T7064 | Valproic Acid | Sodium valproate,2-Propylpentanoic Acid,VPA,Depakine,2-Propylvaleric Acid | Mitophagy , Gamma-secretase , HIV Protease , GABA Receptor , Sodium Channel , HDAC , Autophagy |
Valproic Acid (2-Propylpentanoic Acid) is an HDAC inhibitor that inhibits HDAC1 activity, induces HDAC2 degradation, and is orally active. Valproic Acid can be used in epilepsy and bipolar disorder research. | |||
T14680 | BMS-906024 | Osugacestat,AL-101,BM-0018 | Gamma-secretase |
BMS-906024 (Osugacestat) is an orally available and selective inhibitor of γ-secretase, a small molecule Notch inhibitor.BMS-906024 has broad-spectrum antitumour activity against a variety of human cancer xenografts.BMS-... | |||
T72984 | (Rac)-SHIN2 | Others | |
(Rac)-SHIN2 is a serine hydroxymethyltransferase (SHMT) inhibitor that enhances NOTCH1-driven in vivo survival of primary T-ALL in mice and can be used to study T-cell acute lymphoblastic leukemia (T-ALL). | |||
T7522 | GI254023X | GI 254023X | MMP , Immunology/Inflammation related |
GI254023X is a potent MMP9 and ADAM10 inhibitor (IC50s: 2.5 and 5.3 nM) with 100-fold selectivity for the α-secretase ADAM10 over ADAM17 (TACE). GI254023X can remarkably inhibit the proliferation and induce the apoptosis... | |||
T3633 | Crenigacestat | LY3039478 | Gamma-secretase |
Crenigacestat (LY3039478) is an orally bioavailable Notch inhibitor with an IC50 of ~1 nM in most of the tumor cell lines tested. Crenigacestat effectively inhibits mutant Notch receptor activity. In a xenograft tumor mo... | |||
T76785 | Brontictuzumab | ||
Brontictuzumab (OMP 52M51), a monoclonal antibody (MAb), selectively targets and binds to the negative regulatory region of Notch1, inhibiting its signaling. This action inhibits tumor cell proliferation, rendering Bront... | |||
T16341 | Notch inhibitor 1 | Others | |
Notch inhibitor 1 is an effective Notch inhibitor (IC50s: 7.8 and 8.5 nM for Notch 1 and Notch 3, respectively). Notch inhibitor 1 is also used in the research of cancer. |