store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BMS-906024 (Osugacestat) is an orally available and selective inhibitor of γ-secretase, a small molecule Notch inhibitor.BMS-906024 has broad-spectrum antitumour activity against a variety of human cancer xenografts.BMS-906024 prevents the activation of all four Notch receptors, and is active against Notch1, -2, -3 and -4 receptors. BMS-906024 prevents the activation of all four Notch receptors, with IC50s of 1.6, 0.7, 3.4 and 2.9 nM for Notch1, -2, -3 and -4 receptors, respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 565.00 | |
2 mg | In stock | $ 788.00 | |
5 mg | In stock | $ 1,180.00 | |
10 mg | In stock | $ 1,790.00 | |
25 mg | In stock | $ 2,680.00 | |
50 mg | In stock | $ 3,620.00 | |
100 mg | In stock | $ 4,880.00 |
Description | BMS-906024 (Osugacestat) is an orally available and selective inhibitor of γ-secretase, a small molecule Notch inhibitor.BMS-906024 has broad-spectrum antitumour activity against a variety of human cancer xenografts.BMS-906024 prevents the activation of all four Notch receptors, and is active against Notch1, -2, -3 and -4 receptors. BMS-906024 prevents the activation of all four Notch receptors, with IC50s of 1.6, 0.7, 3.4 and 2.9 nM for Notch1, -2, -3 and -4 receptors, respectively. |
Targets&IC50 | Notch2:0.7 nM, Notch1:1.6 nM, Notch3:3.4 nM, Notch4:2.9 nM |
In vitro | BMS-906024 (100 nM; 72 h) is an effective Notch activation inhibitor, which enhances the in vitro anti-tumor activity of paclitaxel[1]. |
Synonyms | Osugacestat, AL-101, BM-0018 |
Molecular Weight | 556.5 |
Formula | C26H26F6N4O3 |
CAS No. | 1401066-79-2 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5 mg/mL (8.98 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
BMS-906024 1401066-79-2 Neuroscience Proteases/Proteasome Stem Cells Gamma-secretase Osugacestat BMS 906024 AL-101 BMS906024 BM-0018 inhibitor inhibit