non-alcoholic — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T12580	PTUPB		COX , Epoxide Hydrolase
	PTUPB is a potent and dual inhibitor of sEH and COX-2 enzymes(IC50 of 0.9 nM and 1.26 μM, respectively).		COX , Epoxide Hydrolase
T31964	Glycolithocholic acid	Lithocholic acid glycine conjugate,Lithocholylglycine	Others
	Glycolithocholic acid (Lithocholic acid glycine conjugate) is a glycine conjugate of lithocholic acid.		Others
T27061	CP-24879 hydrochloride	CP-24879 HCl	Others
	CP-24879 hydrochloride (CP-24879 HCl), a Δ5D/Δ6D dual-inhibitor, can significantly reduce intracellular lipid accumulation and inflammatory injury in hepatocytes. CP-24879 hydrochloride exhibits superior antisteatotic an...		Others
T2601	Vidofludimus	SC12267,4sc-101	Dehydrogenase , DNA/RNA Synthesis , Interleukin
	Vidofludimus (SC12267) (4SC-101, SC12267) is a novel small molecule inhibitor of dihydroorotate dehydrogenase (DHODH).		Dehydrogenase , DNA/RNA Synthesis , Interleukin
T77099	Nimacimab	JNJ 2463,RYI-018	Others
	Nimacimab is a recombinant humanized monoclonal antibody. It can improve diabetes and non-alcoholic steatohepatitis.		Others
T37184	CX08005	2-[(2-tetradecoxyphenyl)carbamoyl]benzoic acid	Phosphatase
	CX08005 is a protein tyrosine phosphatase 1B inhibitor. CX08005 reduces hepatic lipid accumulation and microcirculatory impairment associated with non-alcoholic fatty liver disease.		Phosphatase
T14301	Apararenone	MT-3995	Glucocorticoid Receptor
	Apararenone (MT-3995) is a receptor antagonist of mineralocorticoid receptor which can be used to treat non-alcoholic steatohepatitis and diabetic nephropathy.		Glucocorticoid Receptor
T65815	H-Asp(OtBu)-OtBu HCl		Amino Acids and Derivatives
	H-Asp(OtBu)-OtBu HCl is an aspartic acid derivative that may be used to study comparative neurological function and metabolic disorders of non-alcoholic hepatitis.		Amino Acids and Derivatives
T9186	Ervogastat	PF-06865571	Transferase
	Ervogastat (PF-06865571) is a potent and well-tolerated diacylglycerol acyltransferase 2 inhibitor. Ervogastat reduces steatosis and hepatic triglyceride levels in non-alcoholic steatohepatitis (NASH).		Transferase
T64334	Glycolithocholic acid, sodium salt		Others
	Glycolithocholic acid sodium salt, the sodium form of Glycolithocholic acid, is a glycine-conjugated secondary bile acid utilized in diagnosing ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH), and primary s...		Others
T76700	Simtuzumab	GS 6624,AB 0024	Monoamine Oxidase
	Simtuzumab is a monoclonal antibody against lysyl oxidase-like protein 2 (LOXL2). Simtuzumab can be used to treat primary sclerosing cholangitis (PSC) and is not effective in patients with bridging fibrosis or compensato...		Monoamine Oxidase
T37526	2-Oleoylglycerol	2-Oleoyl Glycerol,2-OG,2-Monoolein	GPR
	2-Oleoylglycerol is a lipid found in palm kernel, sunflower seed and rice bran.2-Oleoylglycerol acts as a GPR119 agonist with neuroprotective effects and induces secretion of glucagon-like peptide 1 (GLP-1).2-Oleoylglyce...		GPR
T67974	Berberine ursodeoxycholate	HTD1801,BUDCA
	Berberine ursodeoxycholate (HTD1801) is an orally effective hypolipidemic agent, an ionic salt of Berberine and Ursodeoxycholic acid.Berberine ursodeoxycholate has a wide range of metabolic activity and significantly red...
T77059	Leronlimab	PRO 140	CCR
	Leronlimab (PRO 140) is a humanized IgG4 anti-CCR5 monoclonal antibody. leronlimumab has both anti-HIV and anti-tumor activity, inhibiting CCR-mediated HIV-1 virus and cancer cell metastasis in mouse tumor models. Leronl...		CCR
T17236	Volixibat	SHP626,LUM002	Others
	Volixibat is a highly selective and competitive apical sodium-dependent bile acid transporter inhibitor. Volixibat has the potential for treatment for non-alcoholic steatohepatitis.		Others
T11448	GOAT-IN-1		Others
	GOAT-IN-1 is an inhibitor of ghrelin O-acyltransferase (GOAT), which could be useful for the prophylaxis or treatment of diabetes, hyperlipidemia, non-alcoholic fatty liver, Alzheimer’s disease, Parkinson’s disease, cere...		Others
T83421	1-Palmitoyl-sn-glycerol 3-phosphate	1-P-GPA
	1-Palmitoyl-sn-glycerol 3-phosphate (1-P-GPA), an endogenous metabolite, is utilized in the research of non-alcoholic fatty liver disease [1].
T35801	ML-262
	ML-262 is an inhibitor of hepatic lipid droplet formation (IC50 = 6.4 nM in murine AML-12 cells), which is associated with non-alcoholic fatty liver disease. ML-262 does not induce cytotoxicity (up to 33 μM) or inhibit f...
T11661	INT-767		FXR , GPCR19
	INT-767 is a potent farnesoid X receptor (FXR)/TGR5 dual agonist that prevents NASH and promotes visceral adipose brown lipogenesis and mitochondrial function for the study of non-alcoholic steatohepatitis.		FXR , GPCR19
T62029	ML261
	ML261 is a inhibitor of hepatic lipid droplets formation with an IC 50 of 69.7 nM. ML261 has research value in non-alcoholic fatty liver disease (NAFLD) and inflammation.