Search Result

Search Results for " mmp2 "

Targets

Compounds

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T61271	MMP2-IN-3		MMP
	MMP2-IN-3 is a potent inhibitor of matrix metalloproteinases (MMP-2) (IC50: 31 μM). MMP2-IN-3 inhibits MMP-9 and MMP-8 with IC50s of 26.6 and 32 μM, respectively.		MMP
T60845	MMP2-IN-1
	MMP2-IN-1 shows siganificant antiproliferative activity in certain cancer cells through arresting the cell cycle and inducing apoptosis. MMP2-IN-1 is a moderate potenet inhibitor of MMP2 (IC 50 = 6.8 μM)[1].
T60551	MMP2-IN-2
	MMP2-IN-2 (compound 42) is a potent and selective inhibitor of MMP-2 (matrix metalloproteinases) with an IC 50 of 4.2 μM. It also shows inhibitory activity against MMP-13, MMP-9 and MMP-8, with IC 50 values of 12, 23.3, ...
T21512	MMP-2/MMP-9 Inhibitor I		MMP
	MMP-2/MMP-9-IN-1 is a potent, highly selective and orally bioavailable inhibitor of type IV collagenases (MMP-9 and MMP-2) with an IC50 of 0.24 and 0.3 1 μM for MMP-9 and MMP-2, respectively. activity, which can be used ...		MMP
T36712	BPHA	MMP-2/MMP-9 Inhibitor II	MMP
	BPHA (MMP-2/MMP-9 Inhibitor II) is a potent, selective and orally active inhibitor of MMP-2, MMP-9 and MMP-14 with IC50s of 12 nM, 16 nM and 17 nM, respectively.BPHA does not inhibit MMP-1, -3 and -7 (IC50s of 974, >1000...		MMP
T9892	JAMM protein inhibitor 2	Acetamide, 2-(2-ethylphenoxy)-N-[2-methyl-4-(1-pyrrolidinyl)phenyl]-	Others
	JAMM protein inhibitor 2 (Acetamide, 2-(2-ethylphenoxy)-N-[2-methyl-4-(1-pyrrolidinyl)phenyl]-) is an inhibitor of JAMM protease and can be used for anticancer studies. The IC50s are 10 μM, 46 μM, and 89 μM for thrombin,...		Others
TP1535L	GPLGIAGQ acetate	GPLGIAGQ acetate(109053-09-0 Free base)	MMP
	GPLGIAGQ acetate is a MMP2-cleavable polypeptide. GPLGIAGQ acetate can be used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers to synthesis unique MMP2-targeted photosensitizer in photodynamic...		MMP
T28145	ND-322 HCl	ND 322 Hydrochloride,ND322 Hydrochloride,ND-322 Hydrochloride,ND322 HCl	MMP
	ND-322 HCl (ND 322 Hydrochloride) is a selective inhibitor of MT1-MMP and MMP2 and reduces in vitro melanoma cell growth, migration and invasion.		MMP
T15015	CTS-1027	RS 130830,Ro 1130830	Others
	CTS-1027 is a small molecule inhibitor of MMPs (IC50s: 0.3 nM, 0.5 nM for MMP2, MMP13). It has > 1,000 fold selectivity over MMP1.		Others
T10597	BR351		MMP
	BR351 is a brain penetrant MMP inhibitor (IC50s: 4, 2, 11, 50 nM for MMP2, MMP8, MMP9 and MMP13).		MMP
T26720	AZD-6605	AZ11920155,AZ-11920155,AZD6605
	AZD6605 is a potent, reversible inhibitor of, MMP2, MMP9, MMP12 and MMP13.
T76055	GPLGIAGQ TFA
	GPLGIAGQ TFA, an MMP2-cleavable polypeptide, serves as a stimulus-sensitive linker in liposomal and micellar nanocarriers for targeted MMP2-triggered tumor therapy. Additionally, it is utilized in the synthesis of unique...
T74714	TP0597850
	TP0597850, a selective MMP2 inhibitor with an IC50 value of 0.22 nM, demonstrates a prolonged dissociation half-life from MMP2 (t1/2 = 265 minutes) [1].
T74632	TP0556351		MMP
	TP0556351, a potent and selective inhibitor of matrix metalloproteinase-2 (MMP2), exhibits significant efficacy with an IC50 of 0.2 nM and demonstrates the capability to decrease collagen accumulation in a Bleomycin-indu...		MMP
TP1624	GPLGIAGQ TFA(109053-09-0 free base)	GPLGIAGQ TFA
	GPLGIAGQ TFA, is an MMP2-cleaved polypeptide that is used as a stimulus-sensitive connector in both liposomes and micelle nanoceroses for targeted therapy of tumors triggered by MMP2.
T26104	Ro 28-2653	Ro 28 2653,Ro-28-2653,Ro282653
	Ro 28-2653 is a matrix-metalloproteinases (MMPs) inhibitor with high selectivity for MMP2, MMP9 and membrane type 1-MMP.
TP1535	GPLGIAGQ
	GPLGIAGQ, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting.
TP1741L	Histatin 5 acetate	Histatin 5 acetate (115966-68-2 Free base)	MMP
	Histatin 5 acetate inhibits the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC50s of 0.57 and 0.25 μM, respectively.		MMP
T69460	TSRI265
	TSRI265 is a novel αvβ3 ligand, disrupting the integrin-MMP2 interaction and showing antiangiogenic activit, inhibiting angiogenesis and tumor growth in vivo.
T10598	BR351 precursor		Others
	BR351 precursor is a precursor of BR351. BR351 is a brain penetrant MMP inhibitor (IC50s: 4, 2, 11, 50 nM for MMP2, MMP8, MMP9 and MMP13).		Others
T2009	SB-3CT		MMP
	SB-3CT is a potent and specific gelatinase inhibitor for MMP-2(Ki=13.9 nM) and MMP-9(Ki=600 nM).		MMP
T78181	MMP-7-IN-2		MMP , Others
	MMP-7-IN-2 acts as a selective and potent MMP7 inhibitor and can be used to study inflammatory responses and vascular-related diseases.		MMP , Others
T6885	Marimastat	BB2516,KB-R8898,TA2516	MMP
	Marimastat (BB2516) (BB-2516) is a potent, broad spectrum matrix metalloprotease (MMP) inhibitor. MMP-9 (IC50=3 nM), MMP-1 (IC50=5 nM), MMP-2 (IC50=6 nM), MMP-14 (IC50=9 nM)and MMP-7 (IC50=13 nM).		MMP
T14322	ARP-100	MMP-2 Inhibitor III	MMP
	ARP-100 (MMP-2 Inhibitor III) is a potent and selective matrix metalloproteinase MMP-2 inhibitor (IC50=12 nM). ARP-100 interacts with the S1' pocket of MMP-2 and exhibits anti-invasive properties in an in vitro invasion ...		MMP
T35859	Aldumastat	GLPG1972,S201086,G504572	Others
	Aldumastat (GLPG1972) is a highly potent, specific and orally active inhibitor of ADAMTS-5.Aldumastat is used for the study of osteoarthritis of the knee.		Others
T16124	MMP13-IN-3		MMP
	MMP13-IN-3 is >1000 selective over other MMPs. MMP13-IN-3 is an effective, selective, and orally active MMP-13 inhibitor (IC50=1 nM) for the potential treatment of osteoarthritis.		MMP
T6011	Batimastat	BB94	MMP
	Batimastat (BB94) (BB-94) is an effective, broad-spectrum matrix metalloprotease (MMP) inhibitor. Batimastat induces extracellular matrix degradation and inhibits angiogenesis, tumor growth and invasion, and metastasis.		MMP
T20563	PD-166793	PD-166793-0000,PD 166793,PD166793	MMP
	PD-166793 is an orally active, potent and selective MMP inhibitor with inhibitory effects on MMP-2, MMP-3 and MMP-13.PD-166793 ameliorates myocardial ischemia and reperfusion injury in a rat model of heart failure.PD-166...		MMP
T2743	Ilomastat	Galardin,GM6001	MMP
	Ilomastat (GM6001) (GM6001, Galardin) is a broad spectrum matrix metalloprotease (MMP) inhibitor.		MMP
T69685	AGPS-IN-2i		MMP
	AGPS-IN-2i is a potent and high-affinity inhibitor of alkylglycerol phosphate synthase that controls ether lipid utilization and metabolism in cells, reduces ether lipid levels and cell migration, and promotes proliferat...		MMP
TP1446	Histatin 5 (TFA)(115966-68-2,free)	Histatin 5 (TFA)	MMP
	Histatin 5 (TFA)(115966-68-2,free) (Histatin 5 (TFA)) inhibits the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC50s of 0.57 and 0.25 μM, respectively.		MMP
T28146	ND-336	ND336,ND-336 hydrochloride,ND 336
	ND-336 is a highly selective inhibitor ofMMP-2, MMP-9 and MMP-14. ND-336 accelerates diabetic wound healing by lowering inflammation and by enhancing angiogenesis and re-epithelialization of the wound.
T41079	MMP13-IN-2	MMP13-IN-2
	MMP13-IN-2 is a highly potent, selective, and orally active inhibitor of MMP-13. It demonstrates exceptional potency against MMP-13, with an IC50 value of 0.036 nM, and exhibits selectivities greater than 1,500-fold over...
T10461	Batimastat sodium salt	BB-94 sodium salt	MMP
	Batimastat (BB-94) sodium salt is a broad-spectrum MMP inhibitor (IC50s: 3, 4, 4, 6, and 20 nM for MMP-1, MMP-2, MMP-9, MMP-7, and MMP-3).		MMP
T12082	MMP3 inhibitor 1		MMP
	MMP3 inhibitor 1 is a potent and highly selective inhibitor of MMP-3 (IC50 of 1 nM).		MMP
T38800	MMPI-1154
	MMPI-1154 is a highly promising imidazole-carboxylic acid (ICA) MMP-2 inhibitor (IC 50 = 6.6 μM) with excellent cardio-cytoprotective properties. It is specifically designed for the study of acute myocardial infarction. ...
T16986	Tanomastat	BAY 12-9566	MMP
	Tanomastat is an orally bioavailable and non-peptidic biphenyl matrix metalloproteinases inhibitor. For MMP-2, MMP-3, MMP-9, MMP-13 the Ki values are 11, 143, 301, and 1470 nM respectively.		MMP
T17201	UK 356618		MMP
	UK 356618 is a potent and selective inhibitor of matrix metalloprotease-3 (IC50: 5.9 nM).		MMP
T13357	XL-784 free base		Others
	XL-784 free base is a selective inhibitor of matrix metalloproteinases (MMP), (IC50s of ~1900, 0.81, 120, 10.8, 18, 0.56 nM for MMP-1,MMP-2,MMP-3,MMP-8,MMP-9,MMP-13,respectively).		Others
T22685	CP-471474	CP 471474	Others
	Broad spectrum MMP inhibitor (IC<sub>50</sub> values are 0.7, 0.9, 13, 16 and 1170 nM for MMP-2, MMP-13, MMP-9, MMP-3 and MMP-1 respectively). Attenuates early left ventricular dilation after experimental myocardial infa...		Others
T13358	XL-784		MMP
	XL-784 is a selective inhibitor of matrix metalloproteinases (MMP)(IC50s of ~1900, 0.81, 120, 10.8, 18, 0.56 nM for MMP-1,MMP-2,MMP-3,MMP-8,MMP-9,MMP-13,respectively).		MMP
T12539L	Prinomastat	KB-R9896,AG3340	MMP
	Prinomastat inhibits MMP-2, MMP-3 and MMP-9 (Kis: 0.05 nM, 0.3 nM and 0.26 nM, respectively). Prinomastat crosses the blood-brain barrier. It also has antitumor activity. Prinomastat is a broad-spectrum, potent, orally a...		MMP
T12539	Prinomastat hydrochloride	KB-R9896 hydrochloride,AG3340 hydrochloride	MMP
	Prinomastat hydrochloride is a orally active inhibitor of metalloproteinase (MMP)(MMP-1, MMP-3 and MMP-9 with IC50s of 79, 6.3 and 5.0 nM , respectively),with Antitumor avtivity.		MMP
T13249	UK-370106		MMP
	UK-370106 is a potent and highly selective inhibitor of MMP-3 with IC50 of 23 nM and MMP-12 with IC50 of 42 nM, and potently inhibits cleavage of [3H]-fibronectin by MMP-3 (IC50: 320 nM).		MMP
T36492	CMC2.24
	CMC2.24 (TRB-N0224) is an orally active tricarbonylmethane agent that demonstrates effectiveness in inhibiting Ras activation and the downstream effector ERK1/2 pathway, thus effectively combating pancreatic tumor format...
T31063	CP-544439	UNII-516DO4KL5R
	CP-544439 is an inhibitor of matrix metalloproteinase-13, which has an effect on adipose tissue development.
T28985	TMI-1	WAY-171318	Apoptosis , MMP
	TMI-1 (WAY-171318), a novel orally active inhibitor of ADAM17 (TACE) and MMP, induces tumor apoptosis in a breast cancer.		Apoptosis , MMP

Compounds

MMP-2/MMP-9 Inhibitor I

Synonym: MMP-2/MMP-9 Inhibitor II

Target: MMP

JAMM protein inhibitor 2

T9892

Synonym: Acetamide, 2-(2-ethylphenoxy)-N-[2-methyl-4-(1-pyrrolidinyl)phenyl]-

Target: Others

GPLGIAGQ acetate

TP1535L

Synonym: GPLGIAGQ acetate(109053-09-0 Free base)

Target: MMP

ND-322 HCl

T28145

Synonym: ND 322 Hydrochloride,ND322 Hydrochloride,ND-322 Hydrochloride,ND322 HCl

Target: MMP

CTS-1027

T15015

Synonym: RS 130830,Ro 1130830

Synonym: AZ11920155,AZ-11920155,AZD6605

GPLGIAGQ TFA(109053-09-0 free base)

TP1624

Synonym: GPLGIAGQ TFA

Target:

Ro 28-2653

T26104

Synonym: Ro 28 2653,Ro-28-2653,Ro282653

Synonym: Histatin 5 acetate (115966-68-2 Free base)

Target: MMP, Others

Marimastat

T6885

Synonym: BB2516,KB-R8898,TA2516

Target: MMP

ARP-100

T14322

Synonym: MMP-2 Inhibitor III

Target: MMP

Aldumastat

T35859

Synonym: GLPG1972,S201086,G504572

Synonym: PD-166793-0000,PD 166793,PD166793

Target: MMP

Ilomastat

T2743

Synonym: Galardin,GM6001

Histatin 5 (TFA)(115966-68-2,free)

TP1446

Synonym: Histatin 5 (TFA)

Target: MMP

ND-336

T28146

Synonym: ND336,ND-336 hydrochloride,ND 336

Target:

MMP13-IN-2

T41079

Synonym: MMP13-IN-2

Target:

Batimastat sodium salt

T10461

Synonym: BB-94 sodium salt

Synonym: KB-R9896,AG3340

Target: MMP

Prinomastat hydrochloride

T12539

Synonym: KB-R9896 hydrochloride,AG3340 hydrochloride

Synonym: UNII-516DO4KL5R

Target: Apoptosis, MMP

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-01477	MMP-2 Protein, Human, Recombinant	Human	HEK293 Cells
	MMP-2 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 72 kDa and the accession number is A0A024R6R4.
TMPY-02290	MMP-2 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	MMP-2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 30.9 kDa and the accession number is P33434-1.
TMPJ-00362	MMP-2 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	72 kDa type IV collagenase also known as matrix metalloproteinase-2 (MMP-2) and gelatinase A is an enzyme that in humans is encoded by the MMP2 gene.It belongs to the matrix metalloproteinase (MMP) family. Matrix metallo...
TMPH-00010	MMP-14 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tiss...
TMPJ-00561	SDC2 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Syndecan-2 is a member of the Syndecans family comprised of type I transmembrane heparan sulfate proteoglycans (HSPG) that are involved in the regulation of many cellular processes. Four sub-types of mammalian Syndecans ...
TMPJ-00433	VSIR Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	platelet receptor Gi24 is a single-pass type I membrane protein, and located at the cell surface. The protein can be cleaved by MMP14, and stimulate MMP14-mediated MMP2 activation. It is participated in the BMP signaling...
TMPH-01297	DDR1 Protein, Human, Recombinant (aa 21-417, His)	Human	HEK293 Cells
	Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival ...