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ND-322 HCl

Catalog No. T28145 CAS 1333379-23-9

Synonyms: ND 322 Hydrochloride, ND322 Hydrochloride, ND-322 Hydrochloride, ND322 HCl

ND-322 HCl (ND 322 Hydrochloride) is a selective inhibitor of MT1-MMP and MMP2 and reduces in vitro melanoma cell growth, migration and invasion.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

ND-322 HCl, CAS 1333379-23-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 195.00
5 mg	In stock	$ 448.00
10 mg	In stock	$ 658.00
25 mg	In stock	$ 987.00
50 mg	In stock	$ 1,380.00
100 mg	In stock	$ 1,890.00
1 mL * 10 mM (in DMSO)	In stock	$ 461.00

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Purity: 98.14%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

ND-322 HCl (ND 322 Hydrochloride) is a selective inhibitor of MT1-MMP and MMP2 and reduces in vitro melanoma cell growth, migration and invasion.

Synonyms	ND 322 Hydrochloride, ND322 Hydrochloride, ND-322 Hydrochloride, ND322 HCl
Molecular Weight	357.88
Formula	C15H16ClNO3S2
CAS No.	1333379-23-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (125.74 mM)

References and Literature

1. Meisel JE, Chang M. Selective small-molecule inhibitors as chemical tools to define the roles of matrix metalloproteinases in disease. Biochim Biophys Acta. 2017 Nov;1864(11 Pt A):2001-2014. 2. Marusak C, et al. The thiirane-based selective MT1-MMP/MMP2 inhibitor ND-322 reduces melanoma tumor growth and delays metastatic dissemination. Pharmacol Res. 2016 Nov;113(Pt A):515-520. 3. Yan Y, et al. Synthesis of chiral ND-322, ND-364 and ND-364 derivatives as selective inhibitors of human gelatinase. Bioorg Med Chem. 2015 Oct 15;23(20):6632-40. 4. Song W, et al. Water-soluble mmp-9 inhibitor prodrug generates active metabolites that cross the blood-brain barrier. ACS Chem Neurosci. 2013 Aug 21;4(8):1168-73.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compounds Library Max Bioactive Compound Library Protease Inhibitor Library

Related Products

Related compounds with same targets

Arctigenin Torilin Lucidenic acid C Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 Aderamastat Methyl rosmarinate Norepinephrine MMP-9-IN-6

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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The answer of 19.713 mg appears in the Mass box

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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

ND-322 HCl 1333379-23-9 Proteases/Proteasome MMP ND 322 Hydrochloride ND 322 HCl ND322 Hydrochloride ND-322 Hydrochloride ND322 HCl inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.