Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tanomastat is an orally bioavailable and non-peptidic biphenyl matrix metalloproteinases inhibitor. For MMP-2, MMP-3, MMP-9, MMP-13 the Ki values are 11, 143, 301, and 1470 nM respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
500 μg | 35 days | $ 88.00 | |
1 mg | 35 days | $ 170.00 | |
5 mg | 35 days | $ 540.00 | |
10 mg | 35 days | $ 990.00 |
Description | Tanomastat is an orally bioavailable and non-peptidic biphenyl matrix metalloproteinases inhibitor. For MMP-2, MMP-3, MMP-9, MMP-13 the Ki values are 11, 143, 301, and 1470 nM respectively. |
Targets&IC50 | MMP2:11 nM (ki), MMP13:1470 nM (ki), MMP9:301 nM (ki), MMP3:143 nM (ki) |
In vitro | Tanomastat (1-00 μM; 5 days) inhibits tubule formation completely at 15-100 μM. Tanomastat (1-10000 nM; 6 hours) prevents matrix invasion by endothelial cells in a concentration-dependent manner (IC50=840 nM) [2][3]. |
In vivo | Tanomastat (100 mg/kg; p.o.; daily for a 7-week period) inhibits local tumor regrowth and inhibits the number and volume of lung metastases [3]. |
Synonyms | BAY 12-9566 |
Molecular Weight | 410.91 |
Formula | C23H19ClO3S |
CAS No. | 179545-77-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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Tanomastat 179545-77-8 Proteases/Proteasome MMP BAY 12-9566 inhibitor inhibit