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Histatin 5 acetate

Catalog No. TP1741L CAS TP1741L

Synonyms: Histatin 5 acetate (115966-68-2 Free base)

Histatin 5 acetate inhibits the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC50s of 0.57 and 0.25 μM, respectively.

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Histatin 5 acetate, CAS TP1741L

Pack Size	Availability	Price/USD
1 mg	In stock	$ 179.00
5 mg	In stock	$ 443.00
10 mg	In stock	$ 653.00
25 mg	In stock	$ 987.00
50 mg	In stock	$ 1,390.00
100 mg	In stock	$ 1,880.00

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Purity: 98.72%

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Description	Histatin 5 acetate inhibits the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC50s of 0.57 and 0.25 μM, respectively.
Targets&IC50	MMP2:0.57 μM, MMP9:0.25 Μm
In vitro	Histatin 5 is a member of a family of low-molecular-weight salivary proteins secreted by parotid, submandibular, and sublingual glands. Using biotinylated gelatin as a substrate, Histatin 5 is found to inhibit the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC50s of 0.57 and 0.25 μM, respectively. To localize the domain responsible for this inhibition, three peptides containing different regions of Histatin 5 are synthesized and tested as inhibitors of MMP-9. Peptides comprising residues 1 to 14 and residues 4 to 15 of Histatin 5 show much lower inhibitory activities (IC50s, 21.4 and 20.5 μM, respectively), while a peptide comprising residues 9 to 22 showed identical activity to Histatin 5 against MMP-9. Kinetic analysis of the inhibition of the Arg-gingipain reveals that Histatin 5 is a competitive inhibitor, affecting only the Km with a Ki of 15 μM. Histatin 5 is an inhibitor of mitochondrial respiration.The human salivary antifungal peptide Histatin 5 is taken up by Candida albicans cells and associates intracellularly with mitochondria. Histatin 5 inhibits respiration of isolated C. albicans mitochondria as well as the respiration of intact blastoconidia in a dose and time-dependent manner. Histatin 5 at a concentration of 33 uM inhibits state 2 respiration.

Synonyms	Histatin 5 acetate (115966-68-2 Free base)
Molecular Weight	3096.35
Formula	C135H199N51O35
CAS No.	TP1741L

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Gusman H, et al. Salivary histatin 5 is an inhibitor of both host and bacterial enzymes implicated in periodontaldisease. Infect Immun. 2001 Mar;69(3):1402-8. 2. Helmerhorst EJ, et al. The human salivary peptide histatin 5 exerts its antifungal activity through the formation ofreactive oxygen species. Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14637-42.

Related compound libraries

This product is contained In the following compound libraries：

Peptide Compound Library Natural Product Library for HTS Anti-Fibrosis Compound Library NO PAINS Compound Library Natural Product Library Protease Inhibitor Library

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Keywords

Histatin 5 acetate TP1741L Proteases/Proteasome MMP Histatin 5 Acetate Histatin 5 acetate (115966-68-2 Free base) 115966-68-2 Free base 115966-68-2 inhibitor inhibit

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