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Ilomastat

Name: Ilomastat
Brand: TargetMol
SKU: T2743
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2743Cas No. 142880-36-2

Alias GM6001, Galardin

Ilomastat (GM6001) (GM6001, Galardin) is a broad spectrum matrix metalloprotease (MMP) inhibitor.

Ilomastat

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Purity: 99.51%

Catalog No. T2743Alias GM6001, GalardinCas No. 142880-36-2

Ilomastat (GM6001) (GM6001, Galardin) is a broad spectrum matrix metalloprotease (MMP) inhibitor.

Pack Size	Price	Availability
1 mg	$41	In Stock
2 mg	$59	In Stock
5 mg	$96	In Stock
10 mg	$156	In Stock
25 mg	$283	In Stock
50 mg	$477	In Stock
100 mg	$688	In Stock
200 mg	$978	In Stock
1 mL x 10 mM (in DMSO)	$101	In Stock

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Purity:99.51%

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COA

Product Introduction

Bioactivity

Description	Ilomastat (GM6001) (GM6001, Galardin) is a broad spectrum matrix metalloprotease (MMP) inhibitor.
Targets&IC50	MMP2:0.5 nM(Ki), MMP26:0.36 nM(Ki), Eastase:20 nM (Ki), MMP9:0.2 nM(Ki), MMP8:0.1 nM(Ki), MMP1:0.4 nM(Ki), Thermolysin:20 nM (Ki), MMP3:1.9 nM
In vivo	Topical application of GM6001 (400 μg/ml) prevents corneal ulceration after severe alkali injury. [3] In rabbit model after stenting, GM6001 significantly inhibits intimal hyperplasia and intimalcollagen content, and it increases lumen area in stented arteries without effects on proliferation rates. [4]
Kinase Assay	Collagenase assay uses the synthetic thiol ester substrate Ac-Pro-Leu-Gly-SCH(i-Bu)CO-Leu-Gly-OEt at pH 6.5. The collagenase concentration is 1-2 nM, and the substrate concentrations are from 0.1 to 0.7 nM. Km?is found to vary between 1.5 and 4 mM.
Synonyms	GM6001, Galardin

Chemical Properties

Molecular Weight	388.46
Formula	C₂₀H₂₈N₄O₄
Cas No.	142880-36-2
Smiles	CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)CC(=O)NO
Relative Density.	1.228 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 83.32 mg/mL (214.49 mM)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (8.5 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5743 mL	12.8713 mL	25.7427 mL	128.7134 mL
5 mM	0.5149 mL	2.5743 mL	5.1485 mL	25.7427 mL
10 mM	0.2574 mL	1.2871 mL	2.5743 mL	12.8713 mL
20 mM	0.1287 mL	0.6436 mL	1.2871 mL	6.4357 mL
50 mM	0.0515 mL	0.2574 mL	0.5149 mL	2.5743 mL
100 mM	0.0257 mL	0.1287 mL	0.2574 mL	1.2871 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc